Cited by 109Natural Antidiabetic Agents StudiesNitric Oxide and Endothelin EffectsMedicinal Plants and Neuroprotection

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats

Open access

Pakdeechote, Poungrat, Bunbupha, Sarawoot, Kukongviriyapan, Upa, Prachaney, Parichat, Khrisanapant, Wilaiwan, Kukongviriyapan, Veerapol·2014·Nutrients

DOI 10.3390/nu6010355PMC PMC3916866

Open this paper in CoChat — free account Open PDF

Abstract

Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS) induced by a high-carbohydrate, high-fat (HCHF) diet. Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were treated with asiatic acid (10 or 20 mg/kg/day) or vehicle for a further three weeks. MS rats had an impairment of oral glucose tolerance, increases in fasting blood glucose, serum insulin, total cholesterol, triglycerides, mean arterial blood pressure, heart rate, and hindlimb vascular resistance; these were related to the augmentation of vascular superoxide anion production, plasma malondialdehyde and tumor necrosis factor-alpha (TNF-α) levels (p<0.05). Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-α, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p<0.05). In conclusion, asiatic acid improved metabolic, hemodynamic abnormalities in MS rats that could be associated with its antioxidant, anti-inflammatory effects and recovering regulation of eNOS/iNOS expression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/nu6010355

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Chemical structure of asiatic acid (from Sigma-Aldrich).CC BY · PubMed Central

Figure 2 Effect of asiatic acid on systolic blood pressure in all experimental groups. Results are expressed as mean ± SEM. AA represents asiatic acid. * p < 0.05 vs. control group, # p < 0.05 vs. MS group (n = 8/group).CC BY · PubMed Central

Figure 3 Effect of asiatic acid on vascular superoxide production (A) and plasma MDA (B) in all experimental groups. Results are expressed as mean ± SEM. AA represents asiatic acid. * p < 0.05 vs. control group, # p < 0.05 vs. MS group (n = 8/group).CC BY · PubMed Central

Figure 4 Effect of asiatic acid on plasma nitric oxide metabolites (NOx) in all experimental groups. Results are expressed as mean ± SEM. AA represents asiatic acid. * p < 0.05 vs. control group, # p < 0.05 vs. MS group (n = 8/group).CC BY · PubMed Central

Figure 5 Effect of asiatic acid on plasma TNF-α in all experimental groups. Results are expressed as mean ± SEM. AA represents asiatic acid. * p < 0.05 vs. control group, # p < 0.05 vs. MS group, † p < 0.05 vs. MS + AA 10 mg/kg group (n = 8/group).CC BY · PubMed Central

Figure 6 Effect of asiatic acid on iNOS protein expression (A) and eNOS protein expression (B) in all experimental groups. Results are expressed as mean ± SEM. AA represents asiatic acid. * p < 0.05 vs. control group, # p < 0.05 vs. MS group, † p < 0.05 vs. MS + AA 10 mg/kg group (n = 4/group).CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

Antinociceptive Activities and the Mechanisms of Anti‐Inflammation of Asiatic Acid in Mice
Huang, S., Chiu, C., Chen, H., Hou, W., Sheu, M., Lin, Y.-C., Shie, P.-H., & Huang, G. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/895857 · Cited by 150
Retracted
Retraction: Asiatic Acid from Potentilla chinensis Attenuate Ethanol-Induced Hepatic Injury via Suppression of Oxidative Stress and Kupffer Cell Activation
Wei, J., Huang, Q., Huang, R., Chen, Y., Lv, S., Wei, L., Liang, C., Liang, S., Zhuo, L., & Lin, X. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00634 · Cited by 40
Retracted
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
TNF-mediated inflammatory disease
Bradley, Jr. (2008) · The Journal of Pathology · doi:10.1002/path.2287 · Cited by 2,094
Fructose-induced insulin resistance and hypertension in rats.
Hwang, I. S., Ho, H., Hoffman, B. B., & Reaven, G. M. (1987) · Hypertension · doi:10.1161/01.hyp.10.5.512 · Cited by 885
Inducible nitric oxide synthase in human diseases
Kröncke, K.-D., Fehsel, K., & Kolb‐Bachofen, V. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00648.x · Cited by 585

Show all 44 references

Sorted by citations

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
Meeran, M. F. N., Goyal, S. N., Suchal, K., Sharma, C., Patil, C. R., & Ojha, S. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00892 · Cited by 201
Sodium—Glucose cotransporter inhibitors and oxidative stress: An update
Yaribeygi, H., Atkin, S. L., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.26760 · Cited by 167
A Comprehensive Review of Cardiovascular Disease Management: Cardiac Biomarkers, Imaging Modalities, Pharmacotherapy, Surgical Interventions, and Herbal Remedies
Netala, V. R., Teertam, S. K., Li, H., & Zhang, Z. (2024) · Cells · doi:10.3390/cells13171471 · Cited by 181
A systematic review of the effect of Centella asiatica on wound healing
Arribas-López, E., Zand, N., Ojo, O., Snowden, M. J., & Kochhar, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063266 · Cited by 143
“asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα) [33,36,37], as well as prostaglandin E2 (PGE2) [36,38], and cyclooxygenase-2 (COX-2) [39].”
BackgroundInfluential
Pentacyclic triterpenes: New tools to fight metabolic syndrome
Sharma, H., Kumar, P., Deshmukh, R. R., Bishayee, A., & Kumar, S. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.09.011 · Cited by 118
Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound
Lv, J., Sharma, A., Zhang, T., Wu, Y., & Ding, X. (2018) · SLAS TECHNOLOGY · doi:10.1177/2472630317751840 · Cited by 112
Wheat phenolics suppress doxorubicin-induced cardiotoxicity via inhibition of oxidative stress, MAP kinase activation, NF-κB pathway, PI3K/Akt/mTOR impairment, and cardiac apoptosis
Sahu, R., Dua, T. K., Das, S., Feo, V. D., & Dewanjee, S. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.01.034 · Cited by 101
Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities against Lipopolysaccharide and d-Galactosamine-Induced Fulminant Hepatic Failure
Lv, H., Zhi-min, Q., Wang, S., Feng, H., Deng, X., & Ci, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00785 · Cited by 100
Beta-caryophyllene protects against diet-induced dyslipidemia and vascular inflammation in rats: Involvement of CB2 and PPAR-γ receptors
Youssef, D. A., El‐Fayoumi, H. M., & Mahmoud, M. F. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.10.010 · Cited by 97
Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review
Razali, N. N. M., Ng, C. T., & Fong, L. Y. (2019) · Planta Medica · doi:10.1055/a-1008-6138 · Cited by 95
Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: The role of CB2 and PPAR-γ receptors
Youssef, D. A., El‐Fayoumi, H. M., & Mahmoud, M. F. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.039 · Cited by 97
Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
Nguyen, H. N., Ullevig, S. L., Short, J. D., Wang, L., Ahn, Y. J., & Asmis, R. (2021) · Antioxidants · doi:10.3390/antiox10081161 · Cited by 89
Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC–MS method
Yuan, Y., Zhang, H., Feng-feng, S. U. N., Sun, S., Zhu, Z., & Chai, Y. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.01.006 · Cited by 79
Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review
Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72
Asiatic Acid Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β/HIF-1α Signaling in Rat H9c2 Cardiomyocytes
Huang, X., Zuo, L., Lv, Y., Chen, C., Yang, Y., Xin, H., Li, Y., & Qian, Y. (2016) · Molecules · doi:10.3390/molecules21091248 · Cited by 66
Neuroprotective effect of asiatic acid against spinal cord injury in rats
Jiang, W., Li, M., He, F., Bian, Z., He, Q., Wang, X., Yao, W., & Zhu, L. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.05.004 · Cited by 64
Asiatic acid alleviates cardiovascular remodelling in rats with L‐ NAME ‐induced hypertension
Bunbupha, S., Prachaney, P., Kukongviriyapan, U., Kukongviriyapan, V., Welbat, J. U., & Pakdeechote, P. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12472 · Cited by 63
Effect of asiatic acid on the Ang II-AT1R-NADPH oxidase-NF-κB pathway in renovascular hypertensive rats
Maneesai, P., Bunbupha, S., Kukongviriyapan, U., Senggunprai, L., Kukongviriyapan, V., Prachaney, P., & Pakdeechote, P. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1408-x · Cited by 52
Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats
Prabhakar, P., Reeta, K. H., Maulik, S., Dinda, A. K., & Gupta, Y. K. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0788-7 · Cited by 47
Effect ofCentella asiaticaon Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models
Zhao, Y., Shu, P., Zhang, Y., Lin, L., Zhou, H., Xu, Z., Suo, D., Xie, A., & Jin, X. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/154295 · Cited by 46
Asiatic Acid Ameliorates Hepatic Lipid Accumulation and Insulin Resistance in Mice Consuming a High-Fat Diet
Yan, S.-L., Yang, H.-T., Lee, Y.-J., Lin, C.-C., Chang, M.-H., & Yin, M.-C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf501165z · Cited by 46
Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats
Maneesai, P., Bunbupha, S., Kukongviriyapan, U., Prachaney, P., Tangsucharit, P., Kukongviriyapan, V., & Pakdeechote, P. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1100-6 · Cited by 46
Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model
Hanapi, N. A., Arshad, A. S. M., Abdullah, J. M., Muhammad, T. S. T., & Yusof, S. R. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.09.015 · Cited by 45
Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action
Duggina, P., Kalla, C. M., Varikasuvu, S. R., Bukke, S., & Tartte, V. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0423-y · Cited by 44
Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies
Sun, Z., Liu, K., Liang, C., Wen, L., Wu, J., Liu, X., & Li, X. (2024) · Phytotherapy Research · doi:10.1002/ptr.8214 · Cited by 43
Kaempferol protects against cardiovascular abnormalities induced by nitric oxide deficiency in rats by suppressing the TNF-α pathway
Maneesai, P., Potue, P., Khamseekaew, J., Sangartit, W., Rattanakanokchai, S., Poasakate, A., & Pakdeechote, P. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176112 · Cited by 39
Possible Involvement of Nitric Oxide Modulatory Mechanisms in the Neuroprotective Effect ofCentella asiaticaAgainst Sleep Deprivation Induced Anxiety Like Behaviour, Oxidative Damage and Neuroinflammation
Chanana, P., & Kumar, A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5582 · Cited by 41
Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats
Jiang, W., Li, M.-Q., He, F., Yao, W., Bian, Z., Wang, X.-P., & Zhu, L.-L. (2016) · Inflammation · doi:10.1007/s10753-016-0414-3 · Cited by 35
Linalool attenuates lipid accumulation and oxidative stress in metabolic dysfunction-associated steatotic liver disease via Sirt1/Akt/PPRA-α/AMPK and Nrf-2/HO-1 signaling pathways
Periyasamy, T., Uddandrao, V. V. S., Chandrasekaran, P., Saravanan, G., Naidu, P. B., Sengottuvelu, S., & Vadivukkarasi, S. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102231 · Cited by 39
Centella Asiatica and Lipoic Acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women
Tomo, P. D., Silvestre, S. D., Cordone, V. G. P., Giardinelli, A., Faricelli, B., Pipino, C., Lanuti, P., Peng, T., Formoso, G., Yang, D., et al. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.04.002 · Cited by 36
Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice
Sangartit, W., Pakdeechote, P., Kukongviriyapan, V., Donpunha, W., Shibahara, S., & Kukongviriyapan, U. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.10.001 · Cited by 36
Amentoflavone improves cardiovascular dysfunction and metabolic abnormalities in high fructose and fat diet-fed rats
Qin, L., Zhao, Y., Zhang, B., & Li, Y. (2017) · Food & Function · doi:10.1039/c7fo01095h · Cited by 38
Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome
Prasatthong, P., Meephat, S., Rattanakanokchai, S., Bunbupha, S., Prachaney, P., Maneesai, P., & Pakdeechote, P. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02291-4 · Cited by 36
Genistein Prevents Nitric Oxide Deficiency-Induced Cardiac Dysfunction and Remodeling in Rats
Poasakate, A., Maneesai, P., Rattanakanokchai, S., Bunbupha, S., Tong-un, T., & Pakdeechote, P. (2021) · Antioxidants · doi:10.3390/antiox10020237 · Cited by 34
Neuroprotective effect of asiatic acid in rat model of focal embolic stroke
Lee, K. Y., Bae, O.-N., Weinstock, S., Kassab, M., & Majid, A. (2014) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00055 · Cited by 31
Centella asiatica triterpenes for diabetic neuropathy: a randomized, double-blind, placebo-controlled, pilot clinical study
Lou, J., Dimitrova, D. M., Murchison, C., Arnold, G. C., Belding, H., Seifer, N., Le, N., Andrea, S. B., Gray, N. E., Wright, K. M., et al. (2018) · Esperienze Dermatologiche · doi:10.23736/s1128-9155.18.00455-7 · Cited by 31
Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis
Zhang, Y., Tu, L., Zhang, Y., Pan, J.-C., Zheng, G., & Yin, L. (2021) · Drug Delivery · doi:10.1080/10717544.2021.2008054 · Cited by 30
Polygonum cuspidatum extract attenuates fructose-induced liver lipid accumulation through inhibiting Keap1 and activating Nrf2 antioxidant pathway
Zhao, X., Chen, L., Zhao, Y., Pan, Y., Yang, Y.-Z., Sun, Y., Jiao, R., & Kong, L. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152986 · Cited by 29
Immunomodulatory and Anti-inflammatory Effects of Asiatic Acid in a DNCB-Induced Atopic Dermatitis Animal Model
Moon, G.-H., Lee, Y., Kim, E., Chung, K., Lee, K.-J., & An, J. H. (2021) · Nutrients · doi:10.3390/nu13072448 · Cited by 29
Anti-cancer activity of asiatic acid against human cholangiocarcinoma cells through inhibition of proliferation and induction of apoptosis
Sakonsinsiri, C., Kaewlert, W., Armartmuntree, N., Thanan, R., & Pakdeechote, P. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.10.5 · Cited by 28
α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats
Prabhakar, P., Reeta, K. H., Maulik, S. K., Dinda, A. K., & Gupta, Y. K. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0088 · Cited by 28
Asiatic acid and its derivatives: Pharmacological insights and applications
Liang, C., Ma, Y., Ding, M., Gao, F., Yu, K., Wang, S., Qu, Y., Hu, X., & Li, D. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117429 · Cited by 30
Diosmetin attenuates metabolic syndrome and left ventricular alterations via the suppression of angiotensin II/AT 1 receptor/gp 91phox /p-NF-κB protein expression in high-fat diet fed rats
Meephat, S., Prasatthong, P., Rattanakanokchai, S., Bunbupha, S., Maneesai, P., & Pakdeechote, P. (2021) · Food & Function · doi:10.1039/d0fo02744h · Cited by 27
Barrier protective effect of asiatic acid in TNF-α-induced activation of human aortic endothelial cells
Fong, L. Y., Ng, C. T., Cheok, Z. L., Moklas, M. A. M., Hakim, M. N., & Ahmad, Z. (2016) · Phytomedicine · doi:10.1016/j.phymed.2015.11.019 · Cited by 26
The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells
Chen, H., Hua, X., Ze, B.-C., Wang, B., & Li, W. (2017) · International Journal of Ophthalmology · doi:10.18240/ijo.2017.02.01 · Cited by 26
Anti inflammatory effect of asiaticoside on human umbilical vein endothelial cells induced by ox-LDL
Li, J., Hai-tao, W., Wang, Q., Fu, Z., Nan, Z., & Xuezheng, Z. (2018) · Cytotechnology · doi:10.1007/s10616-018-0198-4 · Cited by 26
Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects
Chen, X., Zhang, Y., Zhao, P., Chen, Y., Zhou, Y., Wang, S., & Yin, L. (2019) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2019.1701002 · Cited by 26
Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats
Chaihongsa, N., Maneesai, P., Sangartit, W., Potue, P., Bunbupha, S., & Pakdeechote, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119965 · Cited by 26
Asiatic acid-pectin hydrogel matrix patch transdermal delivery system influences parasitaemia suppression and inflammation reduction in P. berghei murine malaria infected Sprague–Dawley rats
Mavondo, G. A., & Musabayane, C. T. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.10.008 · Cited by 24
Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: Role of oxidative stress and inflammation
Attalla, D. M., Ahmed, L. A., Zaki, H. F., & Khattab, M. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.005 · Cited by 24
Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells
Fong, L. Y., Ng, C. T., Yong, Y. K., Hakim, M. N., & Ahmad, Z. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.08.005 · Cited by 24
Asiatic Acid Attenuates the Progression of Left Ventricular Hypertrophy and Heart Failure Induced by Pressure Overload by Inhibiting Myocardial Remodeling in Mice
Si, L., Xu, J., Yi, C., Xu, X., Ma, C., Yang, J., Wang, F., Zhang, Y., & Wang, X. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000304 · Cited by 23
Protective effects of asiatic acid in a spontaneous type 2 diabetic mouse model
Sun, W. C., Xu, G., Guo, X., Luo, G., Wu, L. J., Hou, Y., Guo, X., Zhou, J., Xu, T., Qin, L., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6684 · Cited by 23
Astragaloside IV promotes the eNOS/NO/cGMP pathway and improves left ventricular diastolic function in rats with metabolic syndrome
Lin, X., Wang, Q., Sun, S., Xu, G., Wu, Q., Qi, M., Bai, F., & Yu, J. (2019) · Journal of International Medical Research · doi:10.1177/0300060519826848 · Cited by 23
Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism
Guo, L., Cui, Y., & Hao, K. (2018) · Pharmaceutical Biology · doi:10.1080/13880209.2018.1428634 · Cited by 22
Lactobacillus fermentum HFY06 attenuates d -galactose-induced oxidative stress and inflammation in male Kunming mice
Li, F., Huang, H. Y., Wu, Y., Lu, Z., Zhou, X., Tan, F., & Zhao, X. (2021) · Food & Function · doi:10.1039/d1fo00982f · Cited by 21
Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells
Zhao, J. H., Suyama, A., Chung, H., Fukuda, T., Tanaka, M., & Matsui, T. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.044 · Cited by 20
Preparation, optimization, characterization andin vivopharmacokinetic study of asiatic acid tromethamine salt-loaded solid lipid nanoparticles
Ling-ling, G., Yuan, Z. K., & Lu, W. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2015.1135934 · Cited by 17
Protective effects of Asiatic acid against pelvic inflammatory disease in rats
Kong, D., Fu, P., Zhang, Q., Ma, X., & Jiang, P. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7498 · Cited by 17
A Pivotal Role of the Nrf2 Signaling Pathway in Spinal Cord Injury: A Prospective Therapeutics Study
Samarghandian, S., Pourbagher‐Shahri, A. M., Ashrafizadeh, M., Khan, H. Z., Forouzanfar, F., Aramjoo, H., & Farkhondeh, T. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200604175118 · Cited by 18
Imperatorin alleviates metabolic and vascular alterations in high-fat/high-fructose diet-fed rats by modulating adiponectin receptor 1, eNOS, and p47phox expression
Bunbupha, S., Prasarttong, P., Poasakate, A., Maneesai, P., & Pakdeechote, P. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174010 · Cited by 16
Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
Bunaim, M. K., Kamisah, Y., Mustazil, M. N. M., Zuhair, J. S. F., Juliana, A. H., & Muhammad, N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.742562 · Cited by 26
Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis
Lokman, M. S., Kassab, R. B., Salem, F. A. M., Elshopakey, G. E., Hussein, A., Aldarmahi, A. A., Theyab, A., Alzahrani, K. J., Hassan, K. E., Alsharif, K. F., et al. (2024) · Bioscience Reports · doi:10.1042/bsr20232004 · Cited by 14
Asiatic acid influences parasitaemia reduction and ameliorates malaria anaemia in P. berghei infected Sprague–Dawley male rats
Mavondo, G. A., Mkhwanazi, B. N., Mabandla, M. V., & Musabayane, C. T. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1338-z · Cited by 14
A ROS balance system with medication and photothermal therapy ability for burn treatment
Wang, X., Yang, H., Fan, G., Sun, A., Qin, J., Zhao, J., Zhang, J., Zhang, W., Wang, H., & Ma, J. (2023) · Journal of Science Advanced Materials and Devices · doi:10.1016/j.jsamd.2023.100534 · Cited by 14
The protective effect of asiatic acid on podocytes in the kidney of diabetic rats.
Chen, Y.-N., Wu, C., Shi, B., Qian, K., & Ding, Y. (2018) · Europe PMC (PubMed Central) · Cited by 14
Maca roots: A potential therapeutic in the management of metabolic disorders through the modulation of metabolic biochemical markers in rats fed high-fat high-carbohydrate diet
Mohamed, S. M., Shalaby, M. A., El‐Shiekh, R. A., Bakr, A. F., Kamel, S., Emam, S. R., & El-Banna, H. A. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117533 · Cited by 13
Indonesian Medicinal Plants with Anti-inflammatory Properties and Potency as Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine
Rahminiwati, M., Trivadila, T., Iswantini, D., Takemori, H., Koketsu, M., Sianipar, R. N. R., Achmadi, S. S., Sjahriza, A., Soebrata, B. M., & Wulanawati, A. (2022) · Pharmacognosy Journal · doi:10.5530/pj.2022.14.119 · Cited by 17
Erratum: Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in mice.
Xiao, W., Jiang, W., Li, K., Hu, Y., Li, S., Zhou, L. N., & Wan, R. (2017) · Europe PMC (PubMed Central) · Cited by 12
Asiatic acid alleviates Ang-II induced cardiac hypertrophy and fibrosis via miR-126/PIK3R2 signaling
Li, H., Tian, X., Ruan, Y., Xing, J., & Meng, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00596-7 · Cited by 14
Severe Malarial Anemia (SMA) Pathophysiology and the Use of Phytotherapeutics as Treatment Options
Mavondo, G. A., & Mzingwane, M. L. (2018) · InTech eBooks · doi:10.5772/intechopen.70411 · Cited by 11
Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis
Jiang, T., Xu, J., Yang, L., Chen, X., & Li, Y. (2022) · Mediators of Inflammation · doi:10.1155/2022/1708030 · Cited by 11
Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet
Maneesai, P., Wattanathorn, J., Potue, P., Khamseekaew, J., Rattanakanokchai, S., Thukham-mee, W., Muchimapura, S., & Pakdeechote, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-39538-z · Cited by 11
Modulatory Effect of Pyrus pyrifolia Fruit and its Phenolics on Key Enzymes against Metabolic Syndrome: Bioassay-Guided Approach, HPLC Analysis, and In Silico Study
Mahdy, N. E., Abdel-Baki, P. M., El-Rashedy, A. A. E., & Ibrahim, R. M. (2023) · Plant Foods for Human Nutrition · doi:10.1007/s11130-023-01069-3 · Cited by 10
Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndrome
Pakdeechote, P., Poasakate, A., Prasatthong, P., Potue, P., Khamseekaew, J., & Maneesai, P. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16500 · Cited by 9
Cardiac remodeling and higher sensitivity to ischemia–reperfusion injury in female rats submitted to high-fat high-sucrose diet: An in vivo/ex vivo longitudinal follow-up
Fourny, N., Lan, C., Kober, F., Boulghobra, D., Bresciani, J., Reboul, C., Bernard, M., & Desrois, M. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.022 · Cited by 9
Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats
Poasakate, A., Maneesai, P., Chiangsaen, P., Bunbupha, S., Settheetham‐Ishida, W., & Pakdeechote, P. (2020) · Andrologia · doi:10.1111/and.13917 · Cited by 8
Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis
de Oliveira, L. M. G., Carreira, R. B., de Oliveira, J. V. R., do Nascimento, R. P., Souza, C. D. S., Trías, E., da Silva, V. D. A., & Costa, S. L. (2023) · Neurotoxicity Research · doi:10.1007/s12640-022-00632-1 · Cited by 8
Synergistic Effect of Asiatic Acid and Madecassic Acid against Antioxidant Deficit in Rat Peripheral Nervous System
Wang, P., Long, T.-F., Wang, L., & Song, J. (2019) · International Journal of Pharmacology · doi:10.3923/ijp.2019.837.843 · Cited by 7
Transdermal Drug Delivery of Asiatic Acid Influences Renal Function and Electrolyte Handling in Plasmodium berghei - Infected Sprague-Dawley Male Rats
Alfred, M. G. (2018) · Journal of Diseases and Medicinal Plants · doi:10.11648/j.jdmp.20180401.13 · Cited by 6
Biochanin-A Protects Rats from Diabetes-associated Cardiorenal Damage by Attenuating Oxidative Stress through Activation of Nrf-2/HO-1 Pathway
Sethumathi, P. P., Uddandrao, V. V. S., Chandrasekaran, P., Sengottuvelu, S., Periyasamy, T., Ponmurugan, P., Vadivukkarasi, S., Santhanakumar, M., Begum, M. S., & Saravanan, G. (2023) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3105 · Cited by 5
Exploring the Mechanism of Asiatic Acid against Atherosclerosis Based on Molecular Docking, Molecular Dynamics, and Experimental Verification
Wu, Z., Yang, L., Wang, R., Yang, J., Liang, P., Ren, W., & Yu, H. J. (2024) · Pharmaceuticals · doi:10.3390/ph17070969 · Cited by 5
Prevention of Hypertension and Arterial Stiffness by Combination of Centella asiatica and Curcuma longa in Rats
Hasimun, P., Mulyani, Y., Sulaeman, A., & Sara, D. A. E. (2019) · Asian Journal of Biological Sciences · doi:10.3923/ajbs.2019.173.179 · Cited by 5
Optimization of ethanolic extraction of asiaticoside and asiatic acid: A stability study and correlation of dielectric constant
Chysirichote, T., Wattanasiriwit, W., & Uraipong, C. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.100899 · Cited by 4
Asiatic acid potentiates the activity of common antidepressant drugs in mice
Poleszak, E., Wośko, S., Szewczyk, B., Wyska, E., Szopa, A., Wróbel, A., Szponar, J., Właź, P., Ołtarzewska, D., Słotwińska, W., et al. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06827-6 · Cited by 3
Antihypertensive activity of spray-dried nanoemulsion containing Asiatic acid-Palm oil in high salt diet-fed rats
Pradana, A. T., Ritthidej, G. C., Limprasutr, V., Wongtayan, A., Lipipun, V., & Iksen, I. (2024) · Pharmacia · doi:10.3897/pharmacia.71.e115091 · Cited by 3
Dietary Triterpenoids
Deng, J., Xiao, J., & Yang, H. (2019) · Springer eBooks · doi:10.1007/978-981-13-1745-3_15-1 · Cited by 3
The Effect of Combined Extracts of Sappan Wood (Caesalpinia sappan L.) and Gotu Kola (Centella asiatica L.) in Improving Diabetic Condition in Rats
Putri, B. M., Wasita, B., & Febrinasari, R. P. (2022) · Jurnal Gizi dan Pangan · doi:10.25182/jgp.2022.17.1.37-46 · Cited by 3
Anti-Inflammatory Effect of Centella asiatica Extract on Prevented Aortic Intima-Media Thickening in Diabetic Rats
Hawas, A. A., Nugrahaningsih, D. A. A., Sholikhah, E. N., Syarifuddin, S., Wijayaningsih, R. A., & Ngatidjan (2018) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.2381 · Cited by 3
Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats
Hasimun, P., Mulyani, Y., Zakaria, H., & Setiawan, A. R. (2021) · Journal Of Biochemical Technology · doi:10.51847/gzeddexleh · Cited by 4
Charting the Phytopharmacological Frontier of Centella asiatica: A Quarter-Century Bibliometric Atlas Unlocking Translational Potential
Yang, J., Zhu, H., Zhang, Q., Dai, Y., Yao, Q., & Nie, X. (2026) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-026-00747-y · Cited by 3
Pharmacology of Anti-obesity and Antidiabetic Phytochemicals Isolated from Various Natural Sources (Plants, Seaweeds, Mushrooms, Marine Animals, and Microorganisms)
Dinda, B., Dinda, S., & Chakraborty, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-92196-5_5 · Cited by 2
Self Nano Emulsifying Drug Delivery System (SNEDDS) Activity of Pegagan (Centella asiatica L) Extraction on Zebrafish Caudal Fins Regeneration
Hayati, F., SALSABILA, T., Chabib, L., & FAWWAZI, M. H. A. F. (2022) · Journal of Research in Pharmacy · doi:10.29228/jrp.288 · Cited by 2
Asiatic acid alleviates vascular remodeling in BAPN ‐induced aortic dissection through inhibiting NF‐κB p65/ CX3CL1 signaling
Zhang, H., Li, Y., Liu, M., Guo, M., Zhang, R., Zhao, K., Wu, J., Zhao, Z., Zhu, H., & Liu, J. (2024) · The FASEB Journal · doi:10.1096/fj.202302327r · Cited by 1
Antiarthritic activity of asiaticoside against the Freund's complete adjuvant-induced rheumatoid arthritis in experimental wistar rats
Ying, J., Zhou, X., Zhao, J., Zhang, Z., & Geng, C. (2021) · Pharmacognosy Magazine · doi:10.4103/pm.pm_247_19 · Cited by 1
Dietary Triterpenoids
Deng, J., Xiao, J., & Yang, H. (2021) · Springer eBooks · doi:10.1007/978-981-15-4148-3_15 · Cited by 2
13. Bioactive nutrients potential impact on cardiometabolic risk factors
Juturu, V. (2017) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-853-7_13
Antidiabetic properties of centella asiatica in type II diabetic rats.
Oyenihi, A. B. (2016) · ResearchSpace (University of KwaZulu-Natal)
Spray dried asiatic acid-palm oil nanoemulsion with improved characteristics and antihypertensive effect study in rat model of hypertension
Pradana, A. T., Ritthidej, G., & Limprasutr, V. (2021) · doi:10.58837/chula.the.2021.203
AKTIVITAS ANTIDISLIPIDEMIA EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica L. Urb) PADA TIKUS WISTAR JANTAN OBESITAS YANG DIINDUKSI PAKAN TINGGI LEMAK DAN KARBOHIDRAT
Kencana, F. F. U. B., Putra, H. M., Istiqomah, A. N., & Safitri, S. R. (2023) · Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan · doi:10.36387/jiis.v8i2.1076

Authors: Pakdeechote, P., Bunbupha, S., Kukongviriyapan, U., Prachaney, P., Khrisanapant, W., & Kukongviriyapan, V.
Affiliations: Khon Kaen University (TH)
Corresponding author: Pakdeechote, Poungrat
ORCID: Pakdeechote, Poungrat
Bunbupha, Sarawoot
Kukongviriyapan, Upa
Prachaney, Parichat
Khrisanapant, Wilaiwan
Kukongviriyapan, Veerapol
Venue: Nutrients
Publisher: MDPI AG
Published: 2014-01-16
Volume: 6
Issue: 1
Pages: 355-370
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu6010355
PMC: PMC3916866
OpenAlex: W2071030426
Cited by: 109
References: 44
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 15 · 2020: 4 · 2019: 11 · 2018: 16 · 2017: 7 · 2016: 12 · 2015: 6 · 2014: 5
FWCI: 8.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: asiatic acid, Centella asiatica, triterpenoids, metabolic syndrome, high-fat high-carbohydrate diet, fructose-induced obesity, endothelial nitric oxide synthase, inducible nitric oxide synthase, nitric oxide, oxidative stress, inflammation, TNF-α, malondialdehyde, insulin resistance, glucose tolerance, hemodynamics, lipid profile, cardiovascular complications
MeSH terms: Animals, Anti-Inflammatory Agents, Antioxidants, Blood Glucose, Diet, Glucose Tolerance Test, Hemodynamics, Inflammation, Insulin, Insulin Resistance, Male, Malondialdehyde, Nitrates, Nitrites, Triglycerides, Tumor Necrosis Factor-alpha, Gene Expression, Rats, Sprague-Dawley, Oxidative Stress, Metabolic Syndrome, Rats, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, Pentacyclic Triterpenes, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks