The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Potential Role of Carotenoids as Antioxidants in Human Health and Disease
Open accessAbstract
Carotenoids constitute a ubiquitous group of isoprenoid pigments. They are very efficient physical quenchers of singlet oxygen and scavengers of other reactive oxygen species. Carotenoids can also act as chemical quenchers undergoing irreversible oxygenation. The molecular mechanisms underlying these reactions are still not fully understood, especially in the context of the anti- and pro-oxidant activity of carotenoids, which, although not synthesized by humans and animals, are also present in their blood and tissues, contributing to a number of biochemical processes. The antioxidant potential of carotenoids is of particular significance to human health, due to the fact that losing antioxidant-reactive oxygen species balance results in “oxidative stress”, a critical factor of the pathogenic processes of various chronic disorders. Data coming from epidemiological studies and clinical trials strongly support the observation that adequate carotenoid supplementation may significantly reduce the risk of several disorders mediated by reactive oxygen species. Here, we would like to highlight the beneficial (protective) effects of dietary carotenoid intake in exemplary widespread modern civilization diseases, i.e., cancer, cardiovascular or photosensitivity disorders, in the context of carotenoids’ unique antioxidative properties.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“β-carotene is the precursor of retinoic acid [154,155].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: Dynamic Action of Carotenoids in Cardioprotection and Maintenance of Cardiac Health
Agarwal, M., Parameswari, R. P., Vasanthi, H. R., & Das, D. K. (2012) · Molecules · doi:10.3390/molecules17044755 · Cited by 53
RetractedFree Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575
Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397
Flagged first, then by citations
Research works printed but not linked: 3
- Britton, 2009, Modulation of Intracellular Signaling Pathways by Carotenoids, Carotenoids: Nutrition and Health, Volume 5, 211
- Landrum, J.T. (2010). Carotenoids: Physical, Chemical, and Biological Functions and Properties, CRC Press, Taylor & Francis Group. · DOI
- Grune, 2005, Low Molecular Weight Antioxidants, The Handbook of Environmental Chemistry, Volume 2, 77
Cited by
Sorted by citations
Items 1,001–1,001 of 1,001
Shi, H., Cui, B., Lv, L., Dong, Y., Lin, Z., Xu, J., & Yao, H. (2025) · Aquaculture Reports · doi:10.1016/j.aqrep.2025.102674 · Cited by 4
Metadata
- Authors
- Fiedor, J., & Burda, K.
- Affiliations
- AGH University of Krakow (PL)
- Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH-University of Science and Technology, al. A. Mickiewicza 30, Kraków 30-059, Poland
- Corresponding author
- Fiedor, Joanna
- ORCID
- Fiedor, Joanna
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2014-01-27
- Volume
- 6
- Issue
- 2
- Pages
- 466-488
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC3942711
- OpenAlex
- W2086169535
- Cited by
- 1,420
- References
- 169
- Citations by year
- 2026: 77 · 2025: 110 · 2024: 133 · 2023: 138 · 2022: 159 · 2021: 165 · 2020: 190 · 2019: 146 · 2018: 109 · 2017: 82 · 2016: 64 · 2015: 36 · 2014: 10
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- carotenoids, antioxidants, reactive oxygen species, singlet oxygen quenching, oxidative stress, carotenoid supplementation, dietary carotenoids, cancer, cardiovascular disease, photodermatosis, chronic disease prevention
- MeSH terms
- Antioxidants, Carotenoids, Chronic Disease, Clinical Trials as Topic, Humans, Risk Factors, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
