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Potential Role of Carotenoids as Antioxidants in Human Health and Disease

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Fiedor, Joanna, Burda, Květoslava·2014·Nutrients

DOI 10.3390/nu6020466PMC PMC3942711

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Abstract

Carotenoids constitute a ubiquitous group of isoprenoid pigments. They are very efficient physical quenchers of singlet oxygen and scavengers of other reactive oxygen species. Carotenoids can also act as chemical quenchers undergoing irreversible oxygenation. The molecular mechanisms underlying these reactions are still not fully understood, especially in the context of the anti- and pro-oxidant activity of carotenoids, which, although not synthesized by humans and animals, are also present in their blood and tissues, contributing to a number of biochemical processes. The antioxidant potential of carotenoids is of particular significance to human health, due to the fact that losing antioxidant-reactive oxygen species balance results in “oxidative stress”, a critical factor of the pathogenic processes of various chronic disorders. Data coming from epidemiological studies and clinical trials strongly support the observation that adequate carotenoid supplementation may significantly reduce the risk of several disorders mediated by reactive oxygen species. Here, we would like to highlight the beneficial (protective) effects of dietary carotenoid intake in exemplary widespread modern civilization diseases, i.e., cancer, cardiovascular or photosensitivity disorders, in the context of carotenoids’ unique antioxidative properties.

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Authors: Fiedor, J., & Burda, K.
Affiliations: AGH University of Krakow (PL)
Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH-University of Science and Technology, al. A. Mickiewicza 30, Kraków 30-059, Poland
Corresponding author: Fiedor, Joanna
ORCID: Fiedor, Joanna
Venue: Nutrients
Publisher: MDPI AG
Published: 2014-01-27
Volume: 6
Issue: 2
Pages: 466-488
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu6020466
PMC: PMC3942711
OpenAlex: W2086169535
Cited by: 1,420
References: 169
Citations by year: 2026: 77 · 2025: 110 · 2024: 133 · 2023: 138 · 2022: 159 · 2021: 165 · 2020: 190 · 2019: 146 · 2018: 109 · 2017: 82 · 2016: 64 · 2015: 36 · 2014: 10
FWCI: 6.17
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: carotenoids, antioxidants, reactive oxygen species, singlet oxygen quenching, oxidative stress, carotenoid supplementation, dietary carotenoids, cancer, cardiovascular disease, photodermatosis, chronic disease prevention
MeSH terms: Antioxidants, Carotenoids, Chronic Disease, Clinical Trials as Topic, Humans, Risk Factors, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements

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Potential Role of Carotenoids as Antioxidants in Human Health and Disease

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