The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism
Open accessAbstract
Insulin is required for maintenance of glucose homeostasis. Despite the importance of insulin sensitivity to metabolic health, the mechanisms that induce insulin resistance remain unclear. Branched-chain amino acids (BCAAs) belong to the essential amino acids, which are both direct and indirect nutrient signals. Even though BCAAs have been reported to improve metabolic health, an increased BCAA plasma level is associated with a high risk of metabolic disorder and future insulin resistance, or type 2 diabetes mellitus (T2DM). The activation of mammalian target of rapamycin complex 1 (mTORC1) by BCAAs has been suggested to cause insulin resistance. In addition, defective BCAA oxidative metabolism might occur in obesity, leading to a further accumulation of BCAAs and toxic intermediates. This review provides the current understanding of the mechanism of BCAA-induced mTORC1 activation, as well as the effect of mTOR activation on metabolic health in terms of insulin sensitivity. Furthermore, the effects of impaired BCAA metabolism will be discussed in detail.
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Citations
Cites
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BackgroundInfluential
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Metadata
- Authors
- Yoon, M.-S.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2016-07-01
- Volume
- 8
- Issue
- 7
- Pages
- 405
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2464094535
- Cited by
- 430
- References
- 22
- FWCI
- 29.15
- Type
- journal article
- Language
- en
- Open access
- gold
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