Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type 2 Diabetic Patients
Open accessAbstract
The aim of the current study was to determine the effect of a daily intake of three grams of cinnamon over eight weeks on glycemic indicators, advanced glycation end products, and antioxidant status in patients with type 2 diabetes. In a double-blind, randomized, placebo controlled clinical trial study, 44 patients with type 2 diabetes, aged 57 ± 8 years, were randomly assigned to take either a three g/day cinnamon supplement (n = 22) or a placebo (n = 22) for eight weeks. We measured the fasting blood glucose, insulin, hemoglobinbA1c, homeostasis model assessment for insulin resistance (HOMA-IR), carboxymethyl lysine, total antioxidant capacity, and malondialdehyde levels at the beginning and the end of the study. Thirty-nine patients (20 in the intervention group and 19 in the control group) completed the study. After an eight-week intervention, changes in the level of fasting blood glucose, insulin, hemoglobinbA1c, HOMA-IR, carboxymethyl lysine, total antioxidant capacity, and malondialdehyde were not significant in either group, nor were any significant differences between groups observed in these glycemic and inflammatory indicators at the end of the intervention. Our study revealed that cinnamon supplementation had no significant effects on glycemic and inflammatory indicators in patients with type 2 diabetes.
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Results from 6 RCTs did not find a difference in blood glucose or insulin levels after cinnamon consumption.
“Results from 6 RCTs did not find a difference in blood glucose or insulin levels after cinnamon consumption [368,377,378,379,380,381,382].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [377]
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“Another intervention study with a single cinnamon supplement (3g) during 16 weeks resulted in improvements in fasting blood sugar & all constituents of metabolic syndrome significant in a sample of Asian North Indian sample patients6 Based on the study designed as a triple-blind placebo-controlled randomized clinical…”
Result「腎疾患対策検討会報告書」が示す今後の慢性腎臓病対策 (特集 知っていますか? 慢性腎臓病(CKD))
菱田, 明. (2008) · 食生活
TARÇIN GERÇEKTEN KAN ŞEKERİNİ DÜŞÜRÜYOR MU
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ALIMENTOS COM PROPRIEDADES FUNCIONAIS E DE SAÚDE: EVIDÊNCIAS E PRETENSOS EFEITOS
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Antidiabetic drugs and marketed formulations from natural products
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The Role of Herbal Supplements in Type 2 Diabetes Management: An Evidence from a Systematic Review
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“Some trials have reported metabolic benefits, particularly at doses of 3 g/day, including improvements in glycemic parameters and body composition [18–21], although findings have been inconsistent [15].”
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- Authors
- Talaei, B., Amouzegar, A., Sahranavard, S., Hedayati, M., Mirmiran, P., & Azizi, F.
- Affiliations
- Kerman University of Medical Sciences (IR)
- Research Institute for Endocrine Sciences (IR)
- Shahid Beheshti University (IR)
- National Nutrition and Food Technology Research Institute (IR)
- Corresponding author
- Mirmiran, Parvin
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2017-09-08
- Volume
- 9
- Issue
- 9
- Pages
- 991
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC5622751
- OpenAlex
- W2750958340
- Cited by
- 82
- References
- 28
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 14 · 2022: 10 · 2021: 17 · 2020: 6 · 2019: 9 · 2018: 4
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- cinnamon, type 2 diabetes, glycemic control, advanced glycation end products, carboxymethyllysine, antioxidant status, oxidative stress, insulin resistance, HOMA-IR, fasting blood glucose, HbA1c, malondialdehyde, dietary supplementation
- MeSH terms
- Aged, Antioxidants, Blood Glucose, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Double-Blind Method, Glycated Hemoglobin, Homeostasis, Humans, Insulin, Lysine, Malondialdehyde, Middle Aged, Glycation End Products, Advanced
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