Cited by 101Gut microbiota and healthKidney Stones and Urolithiasis TreatmentsGastrointestinal motility and disorders

The Metabolic and Ecological Interactions of Oxalate-Degrading Bacteria in the Mammalian Gut

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Miller, Aaron, Dearing, Denise·2013·Pathogens

Abstract

Oxalate-degrading bacteria comprise a functional group of microorganisms, commonly found in the gastrointestinal tract of mammals. Oxalate is a plant secondary compound (PSC) widely produced by all major taxa of plants and as a terminal metabolite by the mammalian liver. As a toxin, oxalate can have a significant impact on the health of mammals, including humans. Mammals do not have the enzymes required to metabolize oxalate and rely on their gut microbiota for this function. Thus, significant metabolic interactions between the mammalian host and a complex gut microbiota maintain the balance of oxalate in the body. Over a dozen species of gut bacteria are now known to degrade oxalate. This review focuses on the host-microbe and microbe-microbe interactions that regulate the degradation of oxalate by the gut microbiota. We discuss the pathways of oxalate throughout the body and the mammalian gut as a series of differentiated ecosystems that facilitate oxalate degradation. We also explore the mechanisms and functions of microbial oxalate degradation along with the implications for the ecological and evolutionary interactions within the microbiota and for mammalian hosts. Throughout, we consider questions that remain, as well as recent technological advances that can be employed to answer them.

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Crossref · 10.3390/pathogens2040636

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  • Recent evidence suggests that blood oxalate levels are influenced by gut microbiota, with over a dozen oxalate-degrading gut bacterial species identified.

    “Recent evidence suggests that blood levels are also influenced by gut microbiota, with over a dozen oxalate-degrading gut bacterial species identified (28).”

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Authors
Miller, A., & Dearing, D.
Affiliations
  • University of Utah (US)
  • Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
Corresponding author
Miller, Aaron
Venue
Pathogens
Publisher
MDPI AG
Published
2013-12-06
Volume
2
Issue
4
Pages
636-652
ISSN
2076-0817 (ISSN-L)
OpenAlex
W2152616728
Cited by
101
References
108
Citations by year
2026: 12 · 2025: 12 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 2
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Pathogens (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Science Foundation (1342615)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Kidney Stones and Urolithiasis Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
oxalate-degrading bacteria, gut microbiota, oxalate degradation, host-microbe interactions, plant secondary metabolites, oxalate metabolism, microbial interactions, oxalate toxicity, microbial ecology

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