Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy
Open accessAbstract
Bacterial resistance to antibiotics has made it necessary to resort to antibiotics that have considerable toxicities. Here, we show that the cyclic 9-amino acid peptide CARGGLKSC (CARG), identified via phage display on Staphylococcus aureus (S. aureus) bacteria and through in vivo screening in mice with S. aureus-induced lung infections, increases the antibacterial activity of CARG-conjugated vancomycin-loaded nanoparticles in S. aureus-infected tissues and reduces the needed overall systemic dose, minimizing side effects. CARG binds specifically to S. aureus bacteria but not Pseudomonas bacteria in vitro, selectively accumulates in S. aureus-infected lungs and skin of mice but not in non-infected tissue and Pseudomonas-infected tissue, and significantly enhances the accumulation of intravenously injected vancomycin-loaded porous silicon nanoparticles bearing the peptide in S. aureus-infected mouse lung tissue. The targeted nanoparticles more effectively suppress staphylococcal infections in vivo relative to equivalent doses of untargeted vancomycin nanoparticles or of free vancomycin. The therapeutic delivery of antibiotic-carrying nanoparticles bearing peptides targeting infected tissue may help combat difficult-to-treat infections.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a 20 day efficacy study, 100% of mice administered peptide-functionalized nanoparticles survived, compared with roughly 40% survival in non-functionalized-nanoparticle and free-vancomycin cohorts.
“In a 20 day efficacy study, 100% of the mice administered the peptide-functionalized nanoparticles survived, compared with roughly 40% survival in the non-functionalized-nanoparticle and free-vancomycin cohorts.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839 · see citing works
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · see citing works
Methicillin-Resistant <i>S. aureus</i> Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285 · see citing works
Biodegradable luminescent porous silicon nanoparticles for in vivo applications
Park, J., Gu, L., von Maltzahn, G., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2009) · Nature Materials · doi:10.1038/nmat2398 · Cited by 1,895 · see citing works
Self-citationImmune evasion by staphylococci
Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,214 · see citing works
Proctor, R. A., von Eiff, C., Kahl, B. C., Becker, K., McNamara, P., Herrmann, M., & Peters, G. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1384 · Cited by 1,175 · see citing works
Low, P. S., Henne, W. A., & Doorneweerd, D. D. (2007) · Accounts of Chemical Research · doi:10.1021/ar7000815 · Cited by 1,174 · see citing works
Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors
Sugahara, K. N., Teesalu, T., Karmali, P. P., Kotamraju, V. R., Agemy, L., Girard, O. M., Hanahan, D., Mattrey, R. F., & Ruoslahti, E. I. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.013 · Cited by 1,140 · see citing works
Self-citationCoadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs
Sugahara, K. N., Teesalu, T., Karmali, P. P., Kotamraju, V. R., Agemy, L., Greenwald, D. R., & Ruoslahti, E. I. (2010) · Science · doi:10.1126/science.1183057 · Cited by 1,080 · see citing works
Self-citationUse of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
Daley, J. M., Thomay, A. A., Connolly, M. D., Reichner, J. S., & Albina, J. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407247 · Cited by 1,047 · see citing works
Kukowska‐Latallo, J. F., Candido, K. A., Cao, Z., Nigavekar, S. S., Majoros, I., Thomas, T. P., Balogh, L. P., Khan, M. K., & Baker, J. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3921 · Cited by 912 · see citing works
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus
Lehar, S. M., Pillow, T., Xu, M., Staben, L., Kajihara, K. K., Vandlen, R., DePalatis, L., Raab, H., Hazenbos, W. L., Hiroshi Morisaki, J., et al. (2015) · Nature · doi:10.1038/nature16057 · Cited by 838 · see citing works
King, M. D., Humphrey, B. J., Wang, Y. F., Kourbatova, E. V., Ray, S. M., & Blumberg, H. M. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-5-200603070-00005 · Cited by 776 · see citing works
Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria
Morones‐Ramírez, J. R., Winkler, J. A., Spina, C. S., & Collins, J. J. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006276 · Cited by 759 · see citing works
Tasciotti, E., Liu, X., Bhavane, R. C., Plant, K. D., Leonard, A. D., Price, B. K., Cheng, M. M., Decuzzi, P., Tour, J. M., Robertson, F. M., et al. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.34 · Cited by 669 · see citing works
Rapid translocation of nanoparticles from the lung airspaces to the body
Choi, H. S., Ashitate, Y., Lee, J. H., Kim, S. H., Matsui, A., Insin, N., Bawendi, M. G., Semmler‐Behnke, M., Frangioni, J. V., & Tsuda, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1696 · Cited by 651 · see citing works
Radovic‐Moreno, A. F., Lu, T. K., Puscasu, V. A., Yoon, S.-S., Langer, R., & Farokhzad, O. C. (2012) · ACS Nano · doi:10.1021/nn3008383 · Cited by 542 · see citing works
A tumor-homing peptide with a targeting specificity related to lymphatic vessels
Laakkonen, P. M., Porkka, K., Hoffman, J. A., & Ruoslahti, E. I. (2002) · Nature Medicine · doi:10.1038/nm720 · Cited by 500 · see citing works
Self-citationHybrid Nanoparticles for Detection and Treatment of Cancer
Sailor, M. J., & Park, J. (2012) · Advanced Materials · doi:10.1002/adma.201200653 · Cited by 487 · see citing works
Self-citationStaphylococcus aureus: new evidence for intracellular persistence
Garzoni, C., & Kelley, W. L. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2008.11.005 · Cited by 471 · see citing works
Survival of Staphylococcus aureus Inside Neutrophils Contributes to Infection
Gresham, H. D., Lowrance, J. H., Caver, T. E., Wilson, B. S., Cheung, A. L., & Lindberg, F. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3713 · Cited by 463 · see citing works
Basis of Virulence in Community-Associated Methicillin-Resistant <i>Staphylococcus aureus</i>
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457 · see citing works
Dantes, R. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.10423 · Cited by 452 · see citing works
Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981
Farber, B. F., & Moellering, R. C. (1983) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.23.1.138 · Cited by 433 · see citing works
Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications
Pinto‐Alphandary, H., Andremont, A., & Couvreur, P. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00121-1 · Cited by 428 · see citing works
Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles
Ruoslahti, E. I. (2012) · Advanced Materials · doi:10.1002/adma.201200454 · Cited by 418 · see citing works
Self-citationVaccine protection against Staphylococcus aureus pneumonia
Wardenburg, J. B., & Schneewind, O. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072208 · Cited by 406 · see citing works
Anselmo, A. C., Gupta, V., Zern, B. J., Pan, D. C., Zakrewsky, M., Muzykantov, V. R., & Mitragotri, S. (2013) · ACS Nano · doi:10.1021/nn404853z · Cited by 366 · see citing works
Pathogenesis of Staphylococcus aureus Abscesses
Kobayashi, S. D., Małachowa, N., & DeLeo, F. R. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.11.030 · Cited by 353 · see citing works
Nanoparticle approaches against bacterial infections
Gao, W., Thamphiwatana, S., Angsantikul, P., & Zhang, L. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1282 · Cited by 351 · see citing works
Kell, A. J., Stewart, G., Ryan, S., Peytavi, R., Boissinot, M., Huletsky, A., Bergeron, M. G., & Simard, B. (2008) · ACS Nano · doi:10.1021/nn700183g · Cited by 320 · see citing works
Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
Thwaites, G. E., & Gant, V. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2508 · Cited by 319 · see citing works
Photoexcited quantum dots for killing multidrug-resistant bacteria
Courtney, C. M., Goodman, S. M., McDaniel, J. A., Madinger, N. E., Chatterjee, A., & Nagpal, P. (2016) · Nature Materials · doi:10.1038/nmat4542 · Cited by 280 · see citing works
Moellering, R. C. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr437 · Cited by 236 · see citing works
Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging
Cai, W., & Chen, X. S. (2008) · Nature Protocols · doi:10.1038/nprot.2007.478 · Cited by 227 · see citing works
THE SURVIVAL OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES
Rogers, D. E., & Tompsett, R. R. (1952) · The Journal of Experimental Medicine · doi:10.1084/jem.95.2.209 · Cited by 201 · see citing works
Mann, A. P., Scodeller, P., Hussain, S., Joo, J., Kwon, E. J., Braun, G. B., Mölder, T., She, Z. G., Kotamraju, V. R., Ranscht, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms11980 · Cited by 181 · see citing works
Self-citationA prospective study of adverse reactions associated with vancomycin therapy
Sorrell, T. C., & Collignon, P. (1985) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/16.2.235 · Cited by 175 · see citing works
Zhang, H., Liu, D., Shahbazi, M., Mäkilä, E. M., Herranz‐Blanco, B., Salonen, J., Hirvonen, J. J., & Santos, H. A. (2014) · Advanced Materials · doi:10.1002/adma.201400953 · Cited by 153 · see citing works
Kang, J., Joo, J., Kwon, E. J., Skalak, M., Hussain, S., She, Z., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2016) · Advanced Materials · doi:10.1002/adma.201600634 · Cited by 148 · see citing works
Self-citationiRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes
Simón‐Gracia, L., Hunt, H., Scodeller, P., Gaitzsch, J., Kotamraju, V. R., Sugahara, K. N., Tammik, O., Ruoslahti, E. I., Battaglia, G., & Teesalu, T. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.023 · Cited by 147 · see citing works
Self-citationde Hoog, M., Mouton, J. W., & van den Anker, J. N. (2004) · Clinical Pharmacokinetics · doi:10.2165/00003088-200443070-00001 · Cited by 140 · see citing works
Antibody‐Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs
Secret, E., Smith, K., Dubljevic, V., Moore, E., Macardle, P. J., Delalat, B., Rogers, M., Johns, T. G., Durand, J., Cunin, F., et al. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200335 · Cited by 137 · see citing works
Gated Luminescence Imaging of Silicon Nanoparticles
Joo, J., Liu, X., Kotamraju, V. R., Ruoslahti, E. I., Nam, Y., & Sailor, M. J. (2015) · ACS Nano · doi:10.1021/acsnano.5b01594 · Cited by 127 · see citing works
Self-citationWilhelm, M. P. (1991) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65799-1 · Cited by 124 · see citing works
High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics
Shen, J., Xu, R., Mai, J., Kim, H.-C., Guo, X., Qin, G., Yang, Y. P., Wolfram, J., Mu, C., Xia, X., et al. (2013) · ACS Nano · doi:10.1021/nn4035316 · Cited by 115 · see citing works
Size Control of Porous Silicon Nanoparticles by Electrochemical Perforation Etching
Qin, Z., Joo, J., Gu, L., & Sailor, M. J. (2013) · Particle & Particle Systems Characterization · doi:10.1002/ppsc.201300244 · Cited by 112 · see citing works
Self-citationMapping of Vascular ZIP Codes by Phage Display
Teesalu, T., Sugahara, K. N., & Ruoslahti, E. I. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-396962-0.00002-1 · Cited by 104 · see citing works
Self-citationGarzoni, C., & Kelley, W. L. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100123 · Cited by 104 · see citing works
Joo, J., Kwon, E. J., Kang, J., Skalak, M., Anglin, E. J., Mann, A. P., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2016) · Nanoscale Horizons · doi:10.1039/c6nh00082g · Cited by 99 · see citing works
Self-citationCellular Association and Assembly of a Multistage Delivery System
Serda, R. E., Mack, A. A., Pulikkathara, M. X., Zaske, A. M., Chiappini, C., Fakhoury, J. R., Webb, D., Godin, B., Conyers, J. L., Liu, X. W., et al. (2010) · Small · doi:10.1002/smll.201000126 · Cited by 93 · see citing works
Abed, N., Hassane, F. S., Zouhiri, F., Mougin, J., Nicolas, V., Desmaële, D., Gref, R., & Couvreur, P. (2015) · Scientific Reports · doi:10.1038/srep13500 · Cited by 88 · see citing works
de Boer, M. F., van den Borne, B. H. P., Pruyn, J. F. A., Ryckman, R. M., Volovics, L., Knegt, P. P. M., Meeuwis, C. A., Mesters, I., & Verwoerd, C. D. A. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981215)83:12 · Cited by 82 · see citing works
Photoluminescent Porous Si/SiO 2 Core/Shell Nanoparticles Prepared by Borate Oxidation
Joo, J., Cruz, J. F., Vijayakumar, S., Grondek, J. F., & Sailor, M. J. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201400587 · Cited by 72 · see citing works
Self-citationThe rise and rise ofStaphylococcus aureus: laughing in the face of granulocytes
Anwar, S., Prince, L. R., Foster, S. J., Whyte, M. K. B., & Sabroe, I. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03950.x · Cited by 64 · see citing works
Pai, M. P., Mercier, R.-C., & Koster, S. A. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1g436 · Cited by 62 · see citing works
Chemistry of Antibiotics and Related Drugs
Bhattacharjee, M. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-40746-3 · Cited by 51 · see citing works
Carnazza, S., Foti, C., Gioffrè, G., Felici, F., & Guglielmino, S. P. P. (2007) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2007.11.001 · Cited by 49 · see citing works
Self-citationChemistry and Biochemistry of Antibiotics
Chain, E. B. (1958) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.27.070158.001123 · Cited by 44 · see citing works
Inoshima, I., Inoshima, N., Wilke, G. A., Powers, M. E., Frank, K. M., Wang, Y., & Wardenburg, J. B. (2011) · Nature Medicine · doi:10.1038/nm.2451 · Cited by 21 · see citing works
Pulmonary Infection of Mice with Staphylococcus aureus
DeMaria, T. F., & Kapral, F. A. (1978) · Infection and Immunity · doi:10.1128/iai.21.1.114-123.1978 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,229 · see citing works
Targeting Strategies for Tissue-Specific Drug Delivery
Zhao, Z., Ukidve, A., Kim, J., & Mitragotri, S. (2020) · Cell · doi:10.1016/j.cell.2020.02.001 · Cited by 1,114 · see citing works
Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Zheng, D., Dong, X., Pan, P., Chen, K.-W., Fan, J., Cheng, S., & Zhang, X. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0423-2 · Cited by 483 · see citing works
Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers
Zhao, Z., Ukidve, A., Krishnan, V., & Mitragotri, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.002 · Cited by 449 · see citing works
Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies
Li, W., Thian, E. S., Wang, M., Wang, Z., & Ren, L. (2021) · Advanced Science · doi:10.1002/advs.202100368 · Cited by 440 · see citing works
Yeh, Y.-C., Huang, T., Yang, S.-C., Chen, C.-C., & Fang, J. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00286 · Cited by 417 · see citing works
Aggregation-Induced Emission (AIE), Life and Health
Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 396 · see citing works
Qing, G., Zhao, X., Gong, N., Chen, J., Li, X., Gan, Y., Wang, Y., Zhang, Z., Zhang, Y., Guo, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12313-3 · Cited by 330 · see citing works
Mba, I. E., & Nweze, E. I. (2021) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-021-03070-x · Cited by 333 · see citing works
Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery
Kim, B., Park, J., & Sailor, M. J. (2019) · Advanced Materials · doi:10.1002/adma.201903637 · Cited by 301 · see citing works
Self-citationDong, X., Pan, P., Zheng, D., Bao, P., Zeng, X., & Zhang, X. (2020) · Science Advances · doi:10.1126/sciadv.aba1590 · Cited by 282 · see citing works
Infection microenvironment-related antibacterial nanotherapeutic strategies
Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 269 · see citing works
Qiao, Y., Liu, X., Li, B., Han, Y., Zheng, Y., Yeung, K., Li, C., Cui, Z., Liang, Y., Li, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18268-0 · Cited by 266 · see citing works
Shan, J., Li, X., Yang, K., Xiu, W., Wen, Q., Zhang, Y., Yuwen, L., Weng, L., Teng, Z., & Wang, L. (2019) · ACS Nano · doi:10.1021/acsnano.9b03868 · Cited by 261 · see citing works
Recent Innovations in Bacterial Infection Detection and Treatment
Deusenbery, C. B., Wang, Y., & Shukla, A. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00890 · Cited by 247 · see citing works
Inorganic semiconductor biointerfaces
Jiang, Y., & Tian, B. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0062-3 · Cited by 239 · see citing works
Liu, J., Cabral, H., & Mi, P. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115239 · Cited by 239 · see citing works
Sohrabi, C., Foster, A., & Tavassoli, A. (2020) · Nature Reviews Chemistry · doi:10.1038/s41570-019-0159-2 · Cited by 230 · see citing works
Zhang, X., Zhang, Z.-C., Shu, Q., Xu, C., Zheng, Q., Guo, Z. J., Wang, C., Hao, Z., Liu, X., Wang, G., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008720 · Cited by 230 · see citing works
Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management
Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222 · see citing works
Kim, B., Pang, H., Kang, J., Park, J., Ruoslahti, E. I., & Sailor, M. J. (2018) · Nature Communications · doi:10.1038/s41467-018-04390-7 · Cited by 193 · see citing works
Self-citationKaraman, D. Ş., Ercan, U. K., Bakay, E., Topaloğlu, N., & Rosenholm, J. M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201908783 · Cited by 193 · see citing works
Yuan, L., Liu, X., Tan, L., Cui, Z., Jing, D., Yang, X., Liang, Y., Li, Z., Zhu, S., Zheng, Y., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900946 · Cited by 188 · see citing works
Clegg, J., Soldaini, E., McLoughlin, R. M., Rittenhouse, S. F., Bagnoli, F., & Phogat, S. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705360 · Cited by 180 · see citing works
Visualization and In Situ Ablation of Intracellular Bacterial Pathogens through Metabolic Labeling
Hu, F., Qi, G., Kenry, K., Mao, D., Zhou, S., Wu, M., Wu, W., & Liu, B. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910187 · Cited by 176 · see citing works
Ye, M., Zhao, Y., Wang, Y., Zhao, M., Yodsanit, N., Xie, R., Andes, D. R., & Gong, S. (2021) · Advanced Materials · doi:10.1002/adma.202006772 · Cited by 174 · see citing works
Wu, J., Li, F., Hu, X., Lu, J., Sun, X., Gao, J., & Ling, D. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b00359 · Cited by 170 · see citing works
Dai, W., Shu, R., Yang, F., Li, B., Johnson, H. M., Yu, S., Yang, H., Chan, Y. K., Yang, W., Bai, D., et al. (2023) · Advanced Materials · doi:10.1002/adma.202305277 · Cited by 168 · see citing works
Combination of Rhamnolipid and Chitosan in Nanoparticles Boosts Their Antimicrobial Efficacy
Marangon, C. A., Martins, V. D. C. A., Ma, H. L., Melo, C. C. D., Plepis, A. M. D. G., Meyer, R. L., & Nitschke, M. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b19253 · Cited by 161 · see citing works
Shi, T., Hou, X., Guo, S., Zhang, L., Wei, C., Peng, T., & Hu, X. (2021) · Nature Communications · doi:10.1038/s41467-020-20547-9 · Cited by 161 · see citing works
Wu, S., Huang, Y., Yan, J., Li, Y., Wang, J., Yang, Y. Y., Yuan, P., & Ding, X. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103442 · Cited by 161 · see citing works
Xin, H., Liu, Y., Xiao, Y., Wen, M., Sheng, L., & Jia, Z. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402607 · Cited by 158 · see citing works
Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration
Li, Z., He, D., Guo, B., Wang, Z., Yu, H., Wang, Y., Jin, S., Yu, M., Zhu, L., Chen, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42598-4 · Cited by 133 · see citing works
Yang, Y., Ding, Y., Fan, B. Q., Wang, Y., Mao, Z., Wang, W., & Wu, J. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.030 · Cited by 131 · see citing works
Solid nanoparticles for oral antimicrobial drug delivery: a review
Raza, A., Sime, F. B., Cabot, P. J., Maqbool, F., Roberts, J. A., & Falconer, J. R. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.01.004 · Cited by 128 · see citing works
Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology
Pant, A., Mackraj, I., & Govender, T. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-020-00702-6 · Cited by 136 · see citing works
Surface modification of nano‐drug delivery systems for enhancing antibiotic delivery and activity
Osman, N., Devnarain, N., Omolo, C. A., Fasiku, V. O., Jaglal, Y., & Govender, T. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1758 · Cited by 135 · see citing works
Cheng, Y., Zhang, Y., Zhao, Z., Li, G., Li, J., Li, A., Xue, Y., Zhu, B., Wu, Z., & Zhang, X. (2022) · Advanced Materials · doi:10.1002/adma.202206646 · Cited by 128 · see citing works
Iron and zinc ions, potent weapons against multidrug-resistant bacteria
Ye, Q., Chen, W., Huang, H., Tang, Y., Wang, W., Meng, F., Wang, H., & Zheng, Y. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10600-4 · Cited by 130 · see citing works
Aflakian, F., Mirzavi, F., Aiyelabegan, H. T., Soleimani, A., Navashenaq, J. G., Karimi-Sani, I., Zomorodi, A. R., & Vakili‐Ghartavol, R. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106515 · Cited by 127 · see citing works
Nanotechnology based therapeutics for lung disease
Doroudian, M., MacLoughlin, R. J., Poynton, F. E., Prina‐Mello, A., & Donnelly, S. C. (2019) · Thorax · doi:10.1136/thoraxjnl-2019-213037 · Cited by 127 · see citing works
Jin, X., Xiong, Y., Zhang, X., Wang, R., Xing, Y., Duan, S., Chen, D., Tian, W., & Xu, F. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201807915 · Cited by 119 · see citing works
Wdowiak, M., Paczesny, J., & Raza, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091936 · Cited by 118 · see citing works
Staphylococcal trafficking and infection—from ‘nose to gut’ and back
Raineri, E. J. M., Altulea, D., & van Dijl, J. M. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab041 · Cited by 110 · see citing works
Huang, R., Cai, G.-Q., Li, J., Li, X., Liu, H., Shang, X., Zhou, J., Nie, X., & Gui, R. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00978-2 · Cited by 104 · see citing works
Trends in Photothermal Nanostructures for Antimicrobial Applications
Dediu, V., Ghițman, J., Pîrcălăbioru, G. G., Chan, K. H., Iliescu, F. S., & Iliescu, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119375 · Cited by 101 · see citing works
Xu, S., Chang, L., Hu, Y., Zhao, X., Huang, S., Chen, Z., Ren, X., & Mei, X. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01106-w · Cited by 99 · see citing works
pH‐Responsive Polymer–Drug Conjugate: An Effective Strategy to Combat the Antimicrobial Resistance
Ye, M., Zhao, Y., Wang, Y., Yodsanit, N., Xie, R., & Gong, S. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002655 · Cited by 98 · see citing works
Wu, Y., Deng, G., Jiang, K., Wang, H., Song, Z., & Han, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120588 · Cited by 95 · see citing works
A review on core–shell structured unimolecular nanoparticles for biomedical applications
Chen, G., Wang, Y., Xie, R., & Gong, S. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.008 · Cited by 95 · see citing works
Cai, Q., Fei, Y., Hu, L., Huang, Z., Li, L., & Wang, H. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02286 · Cited by 87 · see citing works
DNA Nanostructures for Targeted Antimicrobial Delivery
Mela, I., Ramirez, P. P. V., Makarchuk, S., Christie, G., Bailey, D. M., Henderson, R. M., Sugiyama, H., Endo, M., & Kaminski, C. F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202002740 · Cited by 87 · see citing works
Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection
Chao, W., Yang, Y., Cao, Y., Liu, K., Shi, H., Guo, X., Liu, W., Hao, R., Song, H., & Zhao, R. (2022) · Biomaterials Science · doi:10.1039/d2bm01489k · Cited by 85 · see citing works
Bose, R. J. C., Tharmalingam, N., Garcia Marques, F. J., Sukumar, U. K., Natarajan, A., Zeng, Y., Robinson, E., Bermudez, A., Chang, E., Habte, F., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00921 · Cited by 84 · see citing works
A Mini Review: Recent Advances in Surface Modification of Porous Silicon
Lee, S. H., Kang, J. S., & Kim, D. (2018) · Materials · doi:10.3390/ma11122557 · Cited by 84 · see citing works
Self-citationA potent antibiotic-loaded bone-cement implant against staphylococcal bone infections
Ghosh, S., Sinha, M., Samanta, R., Sadhasivam, S., Bhattacharyya, A., Nandy, A., Saini, S., Tandon, N., Singh, H., Gupta, S., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00950-x · Cited by 82 · see citing works
Wu, Z., Chan, B., Low, J., Chu, J. J. H., Hey, H. W. D., & Tay, A. K. P. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.02.014 · Cited by 79 · see citing works
Hommes, J. W., & Surewaard, B. G. J. (2022) · Biomedicines · doi:10.3390/biomedicines10081804 · Cited by 80 · see citing works
An Overview of Stimuli-Responsive Intelligent Antibacterial Nanomaterials
Zhang, J., Tang, W., Zhang, X., Song, Z., & Tong, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082113 · Cited by 79 · see citing works
Capeletti, L. B., de Oliveira, J. F. A., Loiola, L. M. D., Galdino, F. E., Santos, D. E. S., Soares, T. A., Freitas, R. O., & Cardoso, M. B. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904216 · Cited by 78 · see citing works
Fathi, H. A., Abdelkader, A., AbdelKarim, M. S., Abdelaziz, A. A., El‐Mokhtar, M. A., Allam, A., Fetih, G. N., Badry, M. E., & Elsabahy, M. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119620 · Cited by 76 · see citing works
Nie, B., Huo, S., Qu, X., Guo, J., Liu, X., Hong, Q., Wang, Y., Yang, J., & Yue, B. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.02.003 · Cited by 76 · see citing works
Intelligent Nanoparticle-Based Dressings for Bacterial Wound Infections
Jiang, L., & Loo, S. C. J. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01168 · Cited by 77 · see citing works
Electrochemical Deposition of Cu Metal–Organic Framework Films for the Dual Analysis of Pathogens
Sun, Z., Peng, Y., Wang, M., Lin, Y., Jalalah, M., Alsareii, S. A., Harraz, F. A., Yang, J. A., & Li, G. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c01763 · Cited by 74 · see citing works
Gao, J., Wang, S., Dong, X., Leanse, L. G., Dai, T., & Wang, Z. (2020) · Communications Biology · doi:10.1038/s42003-020-01410-5 · Cited by 73 · see citing works
Zhu, Y., Liu, X., Tan, L., Cui, Z., Yang, X., Liang, Y., Li, Z., Zhu, S., Yeung, K., & Wu, S. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b12629 · Cited by 71 · see citing works
Functional peptide-based drug delivery systems
Lian, Z., & Ji, T. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00713g · Cited by 71 · see citing works
Photoluminescent and biodegradable porous silicon nanoparticles for biomedical imaging
Park, Y., Yoo, J., Kang, M. H., Kwon, W., & Joo, J. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01042d · Cited by 71 · see citing works
Self-citationStaphylococcus aureus Orchestrates Type 2 Airway Diseases
Teufelberger, A. R., Bröker, B. M., Krysko, D. V., Bachert, C., & Krysko, O. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.003 · Cited by 71 · see citing works
Targeted Therapeutic Strategies in the Battle Against Pathogenic Bacteria
Yang, B., Fang, D., Lv, Q., Wang, Z., & Liu, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.673239 · Cited by 71 · see citing works
Formulation strategies for bacteriophages to target intracellular bacterial pathogens
Yan, W., Banerjee, P., Xu, M. Y., Mukhopadhyay, S., Ip, M., Carrigy, N. B., Lechuga‐Ballesteros, D., To, K. K. W., & Leung, S. S. Y. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113864 · Cited by 67 · see citing works
Ma, K., Dong, P., Liang, M., Yu, S., Chen, Y., & Wang, F. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22043 · Cited by 66 · see citing works
Lê, H., Karakasyan, C., Jouenne, T., Cerf, D. L., & Dé, E. (2021) · Applied Sciences · doi:10.3390/app112210695 · Cited by 68 · see citing works
Jin, L., Liu, X., Zheng, Y., Li, Z., Zhang, Y., Zhu, S., Jiang, H., Cui, Z., Chu, P. K.-H., & Wu, S. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202204437 · Cited by 66 · see citing works
Zhang, Y., Kang, J., Chen, X., Zhang, W., Zhang, X., Yu, W., & Yuan, W. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02209-2 · Cited by 66 · see citing works
Self-citationSafety Assessment of Nanomaterials for Antimicrobial Applications
Ali, A. S., Ovais, M., Cui, X., Rui, Y., & Chen, C. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00519 · Cited by 65 · see citing works
Nanoengineering in biomedicine: Current development and future perspectives
Jian, W., Hui, D., & Lau, D. (2020) · Nanotechnology Reviews · doi:10.1515/ntrev-2020-0053 · Cited by 65 · see citing works
Mohid, S. A., Ghorai, A., Ilyas, H., Mroué, K. H., Narayanan, G., Sarkar, A., Ray, S. K., Biswas, K., Bera, A. K., Malmsten, M., et al. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.01.020 · Cited by 61 · see citing works
Lê, H., Arnoult, C., Dé, E., Schapman, D., Galas, L., Cerf, D. L., & Karakasyan, C. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00082 · Cited by 60 · see citing works
Liu, Y.-H., Kuo, S., Yao, B., Fang, Z.-S., Lee, Y., Chang, Y., Chen, T.-L., & Hu, C. J. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.10.013 · Cited by 60 · see citing works
Advances in Nanostructures for Antimicrobial Therapy
Jampílek, J., & Kráľová, K. (2022) · Materials · doi:10.3390/ma15072388 · Cited by 58 · see citing works
Kang, R. H., Jang, J.-E., Huh, E., Kang, S. J., Ahn, D., Kang, J. S., Sailor, M. J., Yeo, S. G., Oh, M. S., Kim, D., et al. (2020) · Nanoscale Horizons · doi:10.1039/d0nh00077a · Cited by 58 · see citing works
Self-citationLee, M. M. S., Yan, D., Chau, J. H. C., Park, H., Charlie, C. H., Kwok, R. T. K., Lam, J. W. Y., Wang, D., & Tang, B. Z. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120340 · Cited by 58 · see citing works
Zhao, Q. P., Wang, J., Yin, C., Zhang, P., Zhang, J., Shi, M., Shen, K., Xiao, Y., Zhao, Y., Yang, X., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01459 · Cited by 56 · see citing works
Cheng, S., Chen, L., Gong, F., Yang, X., Han, Z., Wang, Y., Ge, J., Gao, X., Li, Y., Zhong, X., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202212489 · Cited by 55 · see citing works
Huang, Y., Chen, Y., Lu, Z., Yu, B., Zou, L., Song, X., Han, H., Jin, Q., & Ji, J. (2023) · Small · doi:10.1002/smll.202302578 · Cited by 55 · see citing works
Gelatinase-responsive release of an antibacterial photodynamic peptide against Staphylococcus aureus
Qiu, L., Wang, C., Lei, X., Du, X., Guo, Q., Zhou, S., Cui, P., Hong, T., Jiang, P., Wang, J., et al. (2021) · Biomaterials Science · doi:10.1039/d0bm02201b · Cited by 55 · see citing works
Li, H., Li, Z., Gu, M., Li, Y., Yi, C., Jiang, M., Yu, X., & Xu, L. (2024) · Advanced Science · doi:10.1002/advs.202406681 · Cited by 54 · see citing works
Rathnayake, K., Patel, U., Pham, C. H., McAlpin, A., Budisalich, T., & Jayawardena, H. S. N. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00622 · Cited by 54 · see citing works
Nanotechnology—A Light of Hope for Combating Antibiotic Resistance
Muteeb, G. (2023) · Microorganisms · doi:10.3390/microorganisms11061489 · Cited by 53 · see citing works
Peng, L., Yang, X., Wang, S., Chan, Y. K., Chen, Y., Yang, Z., Mao, Y., Li, L., Yang, W., & Deng, Y. (2021) · Nanoscale · doi:10.1039/d1nr07611f · Cited by 53 · see citing works
Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin
Tieu, T., Wojnilowicz, M., Huda, P., Thurecht, K. J., Thissen, H. W., Voelcker, N. H., & Cifuentes‐Rius, A. (2020) · Biomaterials Science · doi:10.1039/d0bm01335h · Cited by 55 · see citing works
Antimicrobial micro/nanorobotic materials design: From passive combat to active therapy
Li, J., Shen, H., Zhou, H., Shi, R., Wu, C., & Chu, P. K.-H. (2022) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2022.100712 · Cited by 51 · see citing works
Engineering Micro–Nanomaterials for Biomedical Translation
Chen, Y., Alba, M., Tieu, T., Tong, Z., Minhas, R. S., Rudd, D. A., Voelcker, N. H., Cifuentes‐Rius, A., & Elnathan, R. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100002 · Cited by 51 · see citing works
Antibiotic resistance and nanotechnology: A narrative review
Zhu, X., Tang, Q., Zhou, X., & Momeni, M. R. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106741 · Cited by 50 · see citing works
Peptide-directed synthesis of chiral nano-bipyramids for controllable antibacterial application
Chen, P., Wang, G., Hao, C., Ma, W., Xu, L., Kuang, H., Xu, C., & Sun, M. (2022) · Chemical Science · doi:10.1039/d2sc03443c · Cited by 49 · see citing works
A Targeting Singlet Oxygen Battery for Multidrug‐Resistant Bacterial Deep‐Tissue Infections
Zhu, Y., Gao, M., Su, M., Shen, Y., Zhang, K., Yu, B., & Xu, F. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202306803 · Cited by 49 · see citing works
Arunachalam, K., Pandurangan, P., Shi, C., & Lagoa, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020310 · Cited by 48 · see citing works
Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48 · see citing works
- Authors
- Hussain, S., Joo, J., Kang, J., Kim, B., Braun, G. B., She, Z.-G., Kim, D., Mann, A. P., Mölder, T., Teesalu, T., Carnazza, S., Guglielmino, S., Sailor, M. J., & Ruoslahti, E.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Asan Medical Center (KR)
- University of California San Diego (US)
- University of Tartu (EE)
- University of California, Santa Barbara (US)
- University of Messina (IT)
- Corresponding author
- Ruoslahti, Erkki
- ORCID
- Venue
- Nature Biomedical Engineering
- Published
- 2018-01-22
- Volume
- 2
- Issue
- 2
- Pages
- 95-103
- ISSN
- 2157-846X (ISSN-L)
- PMC
- PMC6015743
- OpenAlex
- W2789337312
- Cited by
- 399
- References
- 61
- Citations by year
- 2026: 26 · 2025: 48 · 2024: 56 · 2023: 52 · 2022: 53 · 2021: 53 · 2020: 61 · 2019: 34 · 2018: 15 · 2012: 1
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Cancer Institute (P30CA030199)
- National Institute of Allergy and Infectious Diseases (R01AI132413)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- antibiotic-loaded nanoparticles, vancomycin, targeted drug delivery, Staphylococcus aureus, phage display, porous silicon nanoparticles, bacterial infection, pulmonary infection, skin infections, antibiotic resistance, Pseudomonas
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
