The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Cell Migration and Invasion Assays as Tools for Drug Discovery
Open accessAbstract
Cell migration and invasion are processes that offer rich targets for intervention in key physiologic and pathologic phenomena such as wound healing and cancer metastasis. With the advent of high-throughput and high content imaging systems, there has been a movement towards the use of physiologically relevant cell-based assays earlier in the testing paradigm. This allows more effective identification of lead compounds and recognition of undesirable effects sooner in the drug discovery screening process. This article will review the effective use of several principle formats for studying cell motility: scratch assays, transmembrane assays, microfluidic devices and cell exclusion zone assays.
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Cites
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PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Tumour-cell invasion and migration: diversity and escape mechanisms
Friedl, P., & Wolf, K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1075 · Cited by 3,222
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
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THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES
Boyden, S. (1962) · The Journal of Experimental Medicine · doi:10.1084/jem.115.3.453 · Cited by 2,733
Compensation mechanism in tumor cell migration
Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U. H., Deryugina, E. I., Strongin, A. Y., Bröcker, E.-B., & Friedl, P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209006 · Cited by 1,391
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Collective migration of an epithelial monolayer in response to a model wound
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Cited by
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform
Katt, M. E., Placone, A. L., Wong, A. D., Xu, Z. S., & Searson, P. C. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2016.00012 · Cited by 754
An introduction to the wound healing assay using live-cell microscopy
Jonkman, J. E. N., Cathcart, J. A., Xu, F., Bartolini, M. E., Amon, J. E., Stevens, K. M., & Colarusso, P. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.36224 · Cited by 729
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
Xiong, Z.-M., O’Donovan, M., Sun, L., Choi, J. Y., Ren, M., & Cao, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-02419-3 · Cited by 112
Wang, X., Sun, Q., & Pei, J. (2018) · Micromachines · doi:10.3390/mi9100493 · Cited by 106
A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion
Toh, Y.-C., Raja, A., Yu, H., & Van Noort, D. (2018) · Bioengineering · doi:10.3390/bioengineering5020029 · Cited by 57
Metadata
- Authors
- Hulkower, K. I., & Herber, R. L.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2011-03-11
- Volume
- 3
- Issue
- 1
- Pages
- 107-124
- ISSN
- 1999-4923 (ISSN-L)
- OpenAlex
- W2164844252
- Cited by
- 395
- References
- 53
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hulkower, K. I., & Herber, R. L. (2011). Cell Migration and Invasion Assays as Tools for Drug Discovery. Pharmaceutics. https://doi.org/10.3390/pharmaceutics3010107
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
