Kuru, the First Human Prion Disease
Open accessAbstract
Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, we summarize the history of this seminal discovery, its anthropological background, epidemiology, clinical picture, neuropathology, and molecular genetics. We provide descriptions of electron microscopy and confocal microscopy of kuru amyloid plaques retrieved from a paraffin-embedded block of an old kuru case, named Kupenota. The discovery of kuru opened new vistas of human medicine and was pivotal in the subsequent transmission of Creutzfeldt–Jakob disease, as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century.
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DOENÇA DE CREUTZFELDT-JAKOB FAMILIAR
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- Authors
- Liberski, P. P., Gajos, A., Sikorska, B., & Lindenbaum, S.
- Affiliations
- Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University Lodz, 90-419 Lodz, Poland
- Medical University of Lodz (PL)
- The Graduate Center, CUNY (US)
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2019-03-07
- Volume
- 11
- Issue
- 3
- Pages
- 232
- ISSN
- 1999-4915 (ISSN-L)
- PMC
- PMC6466359
- OpenAlex
- W2918244676
- Cited by
- 69
- References
- 150
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 7 · 2017: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Viruses (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- kuru, prion disease, human prion disease, chimpanzees, neuropathology, amyloid plaques, electron microscopy, confocal microscopy, Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, transmission to humans
- MeSH terms
- Animals, Cannibalism, Pan troglodytes, Humans, Kuru, Papua New Guinea, Prions, History, 20th Century
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