Cited by 69Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatmentsAmyloidosis: Diagnosis, Treatment, Outcomes

Kuru, the First Human Prion Disease

Open access
Liberski, Paweł P., Gajos, Agata, Sikorska, Beata, Lindenbaum, Shirley·2019·Viruses

Abstract

Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, we summarize the history of this seminal discovery, its anthropological background, epidemiology, clinical picture, neuropathology, and molecular genetics. We provide descriptions of electron microscopy and confocal microscopy of kuru amyloid plaques retrieved from a paraffin-embedded block of an old kuru case, named Kupenota. The discovery of kuru opened new vistas of human medicine and was pivotal in the subsequent transmission of Creutzfeldt–Jakob disease, as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/v11030232

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

12 of the 150 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Liberski, P. P., Gajos, A., Sikorska, B., & Lindenbaum, S.
Affiliations
  • Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and Neuropathology, Medical University Lodz, 90-419 Lodz, Poland
  • Medical University of Lodz (PL)
  • The Graduate Center, CUNY (US)
Venue
Viruses
Publisher
MDPI AG
Published
2019-03-07
Volume
11
Issue
3
Pages
232
ISSN
1999-4915 (ISSN-L)
OpenAlex
W2918244676
Cited by
69
References
150
Citations by year
2026: 3 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 7 · 2017: 1
FWCI
0.86
Type
journal article
Language
en
Open access
Locations
  • Viruses (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
Keywords
kuru, prion disease, human prion disease, chimpanzees, neuropathology, amyloid plaques, electron microscopy, confocal microscopy, Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, transmission to humans
MeSH terms
Animals, Cannibalism, Pan troglodytes, Humans, Kuru, Papua New Guinea, Prions, History, 20th Century

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review