Cited by 86Probiotics and Fermented FoodsInfant Nutrition and HealthReproductive tract infections research

Safety aspects of probiotic products

Open access
Marteau, Philippe·2001·Näringsforskning

Abstract

Probiotics (i.e. ingested living microorganisms) may theoretically be responsible for four types of side effects: systemic infections, deleterious metabolic activities, excessive immune stimulation in susceptible individuals, and gene transfer. Very few cases of adverse events have been reported in humans consuming probiotics, and these are summarized in this paper. I also briefly summarize the three approaches which can be used to assess the safety of a probiotic strain: studies on the intrinsic properties of the strain, studies on its pharmacokinetics, and studies searching for interactions between the strain and the host. Key words: Bifidobacterium, Lactobacillus, probiotics, safety, side effects

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  • Four classes of possible side effects of probiotic use are systemic infections, detrimental metabolic effects, cytokine-mediated immunologic adverse events in susceptible individuals, and transfer of antibiotic resistance genes.

    “Marteau [214] outlined four classes of possible side effects of probiotic use: systemic infections, detrimental metabolic effects, cytokine-mediated immunologic adverse events in susceptible individuals, and transfer of antibiotic resistance genes.”

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Research works printed but not linked: 3

  1. Rautio M, Jousimies-Somer H, Kauma H, Pietarinen I, Saxelin M, Tynkkynen S, Koskela M: Liver abscess due to a Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28: 1 159-60.
  2. Ruseler-van Embden JGH, van Lieshout LMC, Gosselink MJ, Marteau P: Inability of Lactobacillus casei strain GG, L. acidophilus, and Bifido- bacterium bifidum to degrade intestinal mucus glycoproteins: clearing the way for mucosa-protective therapy. Scand J Gastroenterol1995;30:675-80.
  3. Anonymous: A scientific basis for regulations on pathogenic micro- organisms in foods. ILSI Europe (International Life Science Institute, Avenue E Mounier, 83 Box 6, B-1200, Brussels.), Summary of a workshop held in May 1993 and organised by the Scientific Committee on Micro- biology.

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Authors
Marteau, P.
Affiliations
Hôpital Européen Georges-Pompidou (FR)
Corresponding author
Marteau, Philippe
Venue
Näringsforskning
Published
2001-12
Volume
45
Issue
1
Pages
22-24
ISSN
0027-7878 (ISSN-L)
OpenAlex
W2079733493
Cited by
86
References
25
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 4 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
3.04
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
Näringsforskning (publishedVersion, cc-by)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
probiotics, probiotic safety, adverse events, systemic infection, immunostimulation, gene transfer, Bifidobacterium, Lactobacillus, pharmacokinetics

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