Cited by 1,112Nanoparticles: synthesis and applicationsCharacterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug Delivery

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Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

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Singh, Neenu, Jenkins, Gareth J.S., Asadi, Romisa, Doak, Shareen H.·2010·Nano Reviews

DOI 10.3402/nano.v1i0.5358PMC PMC3215220

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Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various biomedical applications, for example, magnetic resonance imaging, targeted delivery of drugs or genes, and in hyperthermia. Although, the potential benefits of SPION are considerable, there is a distinct need to identify any potential cellular damage associated with these nanoparticles. Besides focussing on cytotoxicity, the most commonly used determinant of toxicity as a result of exposure to SPION, this review also mentions the importance of studying the subtle cellular alterations in the form of DNA damage and oxidative stress. We review current studies and discuss how SPION, with or without different surface coating, may cause cellular perturbations including modulation of actin cytoskeleton, alteration in gene expression profiles, disturbance in iron homeostasis and altered cellular responses such as activation of signalling pathways and impairment of cell cycle regulation. The importance of protein-SPION interaction and various safety considerations relating to SPION exposure are also addressed.

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Fig. 1 Cellular toxicity induced by SPION. Exposure to SPION could potentially lead to toxic side effects such as membrane leakage of lactate dehydrogenase, impaired mitochondrial function, inflammation, formation of apoptotic bodies, chromosome condensation, generation of reactive oxygen species (ROS) and DNA damage.CC BY-NC · PubMed Central

Fig. 2 Methods of SPION synthesis. Various methods can be employed for the synthesis of SPION with the desired physico-chemical characteristics. These can be also coated with biocompatible molecules either in situ or via post-synthesis methods wherein the uncoated SPION are surface-coated subsequent to their synthesis.CC BY-NC · PubMed Central

Fig. 3 Schematic representation of different intracellular uptake pathways of SPION. Possible mechanisms of uptake include passive diffusion, receptor-mediated endocytosis, clathrin-mediated endocytosis, caveolin-mediated internalisation, and other calthrin and caveolin-independent endocytosis (105, 106). Upon internalisation, the SPION may presumably be degraded into iron ions in the lysosomes. This ‘free iron’ can potentially cross the nuclear or mitochondrial membrane and in the latter case the free iron in the form of ferrous ions (Fe2+) can react with hydrogen peroxide and oxygen produced by the mitochondria to produce highly reactive hydroxyl radicals and ferric ions (Fe3+) via the Fenton reaction. Hydoxyl radicals (·OH) generated could indirectly damage DNA, proteins and lipids (8-OH-dG=8 hydroxydeoxyguanosine, MDA=malondialdehyde, HNE=4-hydroxy-2-nonenal).CC BY-NC · PubMed Central

Fig. 4 Preliminary data to demonstrate the effect of dextran-coated SPION on the expression of genes involved in iron homeostasis using real-time RT-PCR. (A) TfR1 and (B) hepcidin. The students’ paired t-test was used to determine if down-regulation proved to be significant change in expression (with error bars representing standard deviation (*P<0.05); as compared to the control where water was used in place of the nanoparticles.CC BY-NC · PubMed Central

Fig. 5 Schematic representation of SPION-induced toxicity at cellular level. SPION may cause direct DNA damage or result in the generation of oxidative radicals that in turn have the potential to cause DNA damage (indirect), have an impact on actin cytoskeleton by modulating the Akt signalling pathway, and also alter the expression of various genes such as those involved in cell cycle regulation, iron homeostasis and pancreatic functioning.CC BY-NC · PubMed Central

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Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,906
Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations and biological applications
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Panyam, J., & Labhasetwar, V. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00228-4 · Cited by 3,417
In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis
Fischer, D., Li, Y., Ahlemeyer, B., Krieglstein, J., & Kissel, T. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00445-3 · Cited by 2,329
In vitro toxicity of nanoparticles in BRL 3A rat liver cells
Hussain, S. M., Hess, K. L., Gearhart, J. M., Geiss, K. T., & Schlager, J. J. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.06.034 · Cited by 2,025

Show all 107 references

Research works printed but not linked: 3

Gould P, 2006, Nano Today, 1, 34
10.1016/j.biomaterials.2004.10.012 · DOI
Sodum RS, 1988, Cancer Res, 48, 320

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Triple-stimuli responsive polymers with fine tuneable magnetic responses
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Coupling the magnetic and heat dissipative properties of Fe 3 O 4 particles to enable applications in catalysis, drug delivery, tissue destruction and remote biological interfacing
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Authors: Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H.
Affiliations: Swansea University (GB)
Cardiff University (GB)
Corresponding author: Singh, Neenu
ORCID: Singh, Neenu
Jenkins, Gareth J.S.
Asadi, Romisa
Doak, Shareen H.
Venue: Nano Reviews
Publisher: Informa UK Limited
Published: 2010-01-01
Volume: 1
Issue: 1
Pages: 5358
ISSN: 2000-5121 (ISSN-L)
DOI: 10.3402/nano.v1i0.5358
PMC: PMC3215220
OpenAlex: W2045080998
Cited by: 1,112
References: 107
Citations by year: 2026: 30 · 2025: 63 · 2024: 69 · 2023: 70 · 2022: 87 · 2021: 109 · 2020: 91 · 2019: 78 · 2018: 92 · 2017: 83 · 2016: 83 · 2015: 92 · 2014: 57 · 2013: 60 · 2012: 33
FWCI: 16.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Nano Reviews (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: superparamagnetic iron oxide nanoparticles, nanoparticle toxicity, cytotoxicity, DNA damage, oxidative stress, actin cytoskeleton, gene expression profiling, iron homeostasis, signaling pathways, cell cycle regulation, nanoparticle-protein interactions, surface coating, MRI contrast agents, drug delivery, hyperthermia

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Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

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