The DOI matches its Crossref record; 106 of the 107 references it cites were found in a registry or an index.
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Open accessAbstract
Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various biomedical applications, for example, magnetic resonance imaging, targeted delivery of drugs or genes, and in hyperthermia. Although, the potential benefits of SPION are considerable, there is a distinct need to identify any potential cellular damage associated with these nanoparticles. Besides focussing on cytotoxicity, the most commonly used determinant of toxicity as a result of exposure to SPION, this review also mentions the importance of studying the subtle cellular alterations in the form of DNA damage and oxidative stress. We review current studies and discuss how SPION, with or without different surface coating, may cause cellular perturbations including modulation of actin cytoskeleton, alteration in gene expression profiles, disturbance in iron homeostasis and altered cellular responses such as activation of signalling pathways and impairment of cell cycle regulation. The importance of protein-SPION interaction and various safety considerations relating to SPION exposure are also addressed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Metallic NPs are valuable for their theragnostic capabilities but face significant barriers to translation due to potential long-term toxicity and bioaccumulation, which limit clinical progress [102, 103].”
From Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer's Disease: A Review (2026) · cites this paper as [102]
Experimental — accuracy not yet measuredIn the citing paper
“In vitro, upon prolonged incubation, surface-coated SPION are typically nontoxic at iron concentration up to and 10 μg/ml, while slight cytotoxicity is seen at 100 μg/ml.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [120]
In the citing paper
“In general, SPION toxicity depends on a variety of factors, including - besides dosing and exposure time - also the nature of the coating material, the hydrodynamic diameter of the particle and SPION-protein interactions [119–122].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,906
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Panyam, J., & Labhasetwar, V. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00228-4 · Cited by 3,417
Fischer, D., Li, Y., Ahlemeyer, B., Krieglstein, J., & Kissel, T. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00445-3 · Cited by 2,329
In vitro toxicity of nanoparticles in BRL 3A rat liver cells
Hussain, S. M., Hess, K. L., Gearhart, J. M., Geiss, K. T., & Schlager, J. J. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.06.034 · Cited by 2,025
Flagged first, then by citations
1 of the 107 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Gould P, 2006, Nano Today, 1, 34
- 10.1016/j.biomaterials.2004.10.012 · DOI
- Sodum RS, 1988, Cancer Res, 48, 320
Cited by
Sorted by citations
Items 101–200 of 1,000
Chen, Y., & Hou, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01490-2 · Cited by 122
Magnetic iron oxide nanoparticles as drug delivery system in breast cancer
Marcu, A., Pop, S., Dumitrache, F. V., Mocanu, M. A., Niculite, C. M., Gherghiceanu, M., Lungu, C. P., Fleaca, C. T., Ianchiş, R., Barbut, A., et al. (2013) · Applied Surface Science · doi:10.1016/j.apsusc.2013.02.072 · Cited by 122
Paris, J. L., Baeza, A., & Vallet‐Regí, M. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1662786 · Cited by 121
The interplay of catechol ligands with nanoparticulate iron oxides
Yuen, A. K. L., Hutton, G. A. M., Masters, A. F., & Maschmeyer, T. (2012) · Dalton Transactions · doi:10.1039/c2dt11864e · Cited by 120
Biocompatible polymersomes-based cancer theranostics: Towards multifunctional nanomedicine
Mohammadi, M., Ramezani, M., Abnous, K., & Alibolandi, M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.01.037 · Cited by 119
Physical triggering strategies for drug delivery
Sun, T., Dasgupta, A., Zhao, Z., Nurunnabi, M., & Mitragotri, S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.010 · Cited by 117
Metallic and metal oxide-derived nanohybrid as a tool for biomedical applications
Mujahid, M. H., Upadhyay, T. K., Khan, F., Pandey, P., Park, M. N., Sharangi, A. B., Saeed, M., Upadhye, V. J., & Kim, B. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113791 · Cited by 117
Comfort, K. K., Maurer, E. I., Braydich‐Stolle, L. K., & Hussain, S. M. (2011) · ACS Nano · doi:10.1021/nn203785a · Cited by 115
Combinatorial immunotherapy and nanoparticle mediated hyperthermia
Moy, A. J., & Tunnell, J. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.008 · Cited by 114
In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
Simeonidis, K., Morales, M. P., Marciello, M., Angelakeris, M., de la Presa, P. M., Lázaro-Carrillo, A., Tabero, A., Villanueva, Á., Chubykalo‐Fesenko, O., & Serantes, D. (2016) · Scientific Reports · doi:10.1038/srep38382 · Cited by 113
Liver organ-on-chip models for toxicity studies and risk assessment
Messelmani, T., Morisseau, L., Sakai, Y., Legallais, C., Goff, A. L., Leclerc, É., & Jellali, R. (2022) · Lab on a Chip · doi:10.1039/d2lc00307d · Cited by 113
Hafnium-doped hydroxyapatite nanoparticles with ionizing radiation for lung cancer treatment
Chen, M., Hanagata, N., Ikoma, T., Huang, J.-Y., Li, K.-Y., Lin, C., & Lin, F. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.04.004 · Cited by 112
Sulaiman, G. M., Tawfeeq, A. T., & Naji, A. S. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1366335 · Cited by 110
Bioinspired Negatively Charged Calcium Phosphate Nanocarriers for Cardiac Delivery of MicroRNAs
Mauro, V. D., Iafisco, M., Salvarani, N., Vacchiano, M., Carullo, P., Ramírez‐Rodríguez, G. B., Patrício, T., Tampieri, A., Miragoli, M., & Catalucci, D. (2016) · Nanomedicine · doi:10.2217/nnm.16.26 · Cited by 107
Janko, C., Ratschker, T., Nguyen, K., Zschiesche, L., Tietze, R., Lyer, S., & Alexiou, C. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00059 · Cited by 107
Majeed, M. I., Lu, Q., Yan, W., Li, Z., Hussaın, I., Tahir, M. N., Tremel, W., & Tan, B. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20322k · Cited by 107
Bona, K. R. D., Xu, Y., Ramirez, P. A., DeLaine, J., Parker, C., Bao, Y., & Rasco, J. F. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.09.010 · Cited by 106
Recent advances in waste-recycled nanomaterials for biomedical applications: Waste-to-wealth
Elkodous, M. A., El‐Husseiny, H. M., El-Sayyad, G. S., Hashem, A. H., Doghish, A. S., Elfadil, D., Radwan, Y., El-Zeiny, H. M., Bedair, H., Ikhdair, O. A., et al. (2021) · Nanotechnology Reviews · doi:10.1515/ntrev-2021-0099 · Cited by 106
Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles
Bardestani, A., Ebrahimpour, S., Esmaeili, A., & Esmaeili, A. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01059-0 · Cited by 106
Bernal, G. M., Lariviere, M. J., Mansour, N. M., Pytel, P., Cahill, K. E., Voce, D. J., Kang, S., Spretz, R., Welp, U., Noriega, S. E., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.07.003 · Cited by 104
Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
Rose, J. C., Gehlen, D. B., Haraszti, T., Köhler, J., Licht, C. J., & Laporte, L. D. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.001 · Cited by 104
Ran, Q., Xiang, Y., Liu, Y., Xiang, L., Li, F., Deng, X., Xiao, Y., Chen, L., Chen, L., & Li, Z. (2015) · Scientific Reports · doi:10.1038/srep16209 · Cited by 102
Yu, Y., & Miyako, E. (2018) · iScience · doi:10.1016/j.isci.2018.04.012 · Cited by 102
Sharma, G., Kodali, V., Gaffrey, M. J., Wang, W., Minard, K. R., Karin, N. J., Teeguarden, J., & Thrall, B. D. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.822115 · Cited by 101
Biomedical applications of magneto-responsive scaffolds
Adedoyin, A. A., & Ekenseair, A. K. (2018) · Nano Research · doi:10.1007/s12274-018-2198-2 · Cited by 101
Externally Addressable Smart Drug Delivery Vehicles: Current Technologies and Future Directions
Said, S. S., Campbell, S., & Hoare, T. R. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b01798 · Cited by 101
Novel method for rapid toxicity screening of magnetic nanoparticles
Erofeev, A. S., Gorelkin, P. V., Garanina, A. S., Alova, A. V., Efremova, M. V., Vorobyeva, N. S., Edwards, C., Korchev, Y. E., & Majouga, A. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-25852-4 · Cited by 101
Soares, P. I. P., Romão, J., Matos, R. J. R., Silva, J. A. M. D. C., & Borges, J. P. (2020) · Progress in Materials Science · doi:10.1016/j.pmatsci.2020.100742 · Cited by 100
The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation
Dayem, A. A., Lee, S. B., & Cho, S. (2018) · Nanomaterials · doi:10.3390/nano8100761 · Cited by 98
Boukhalfa, N., Boutahala, M., Djebri, N., & Idris, A. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.102 · Cited by 98
Metal oxide nanoparticles in biomedical applications
Murthy, S., Effiong, P. E., & Fei, C. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817505-7.00011-7 · Cited by 98
Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology
Mohanty, A., Parida, A., Raut, R. K., & Behera, R. K. (2022) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.2c00003 · Cited by 98
Toxicity of Superparamagnetic Iron Oxide Nanoparticles on Green Alga Chlorella vulgaris
Barhoumi, L., & Dewez, D. (2013) · BioMed Research International · doi:10.1155/2013/647974 · Cited by 98
Remya, N. S., Syama, S., Sabareeswaran, A., & Mohanan, P. V. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.119 · Cited by 97
Go, G., Han, J., Zhen, J., Zheng, S., Yoo, A., Jeon, M., Park, J., & Park, S. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601378 · Cited by 96
Kharlamov, A. N., Feinstein, J. A., Cramer, J. A., Boothroyd, J. A., Shishkina, E. V., & Shur, V. Y. (2017) · Future Cardiology · doi:10.2217/fca-2017-0009 · Cited by 96
Iron Oxide Nanoparticles in Bioimaging – An Immune Perspective
Geppert, M., & Himly, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688927 · Cited by 95
Dighe, S., Jog, S., Momin, M. M., Sawarkar, S. P., & Omri, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010058 · Cited by 95
Magnetic immobilization of Bacillus subtilis natto cells for menaquinone-7 fermentation
Ebrahiminezhad, A., Varma, V., Yang, S., & Berenjian, A. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6977-3 · Cited by 94
Hybrid magnetic nanoparticles as efficient nanoheaters in biomedical applications
Lavorato, G. C., Das, R., Alonso, J. A., Phan, M., & Srikanth, H. (2021) · Nanoscale Advances · doi:10.1039/d0na00828a · Cited by 94
Barhoumi, L., Oukarroum, A., Taher, L. B., Smiri, L. S., Abdelmelek, H., & Dewez, D. (2014) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-014-0092-9 · Cited by 94
Abdullah, J. A. A., Jiménez‐Rosado, M., Guerrero, A. F., & Romero, A. (2023) · Materials · doi:10.3390/ma16051798 · Cited by 93
Effects of Fe3O4 Magnetic Nanoparticles on A549 Cells
Watanabe, M., Yoneda, M., Morohashi, A., Hori, Y., Okamoto, D., Satô, A., Kurioka, D., Nittami, T., HIROKAWA, Y. S., Shiraishi, T., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815546 · Cited by 93
Ahmaruzzaman, M., Roy, S., Singha, A., Rtimi, S., & Aminabhavi, T. M. (2025) · Adsorption · doi:10.1007/s10450-024-00588-y · Cited by 92
Developmental and Reproductive Effects of Iron Oxide Nanoparticles in Arabidopsis thaliana
Bombin, S., Lefebvre, M. N., Sherwood, J. A., Xu, Y., Bao, Y., & Ramonell, K. M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161024174 · Cited by 91
Nabil, G., Bhise, K., Sau, S., Atef, M., El-Banna, H. A., & Iyer, A. K. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.08.009 · Cited by 91
Current role of nanoparticles in the treatment of lung cancer
Carrasco-Esteban, E., Domínguez-Rullán, J. A., Barrionuevo-Castillo, P., Pelari-Mici, L., Leaman, O., Sastre-Gallego, S., & López‐Campos, F. (2021) · Journal of Clinical and Translational Research · doi:10.18053/jctres.07.202102.005 · Cited by 92
Insights into the bacterial synthesis of metal nanoparticles
Campaña, A. L., Saragliadis, A., Mikheenko, P., & Linke, D. (2023) · Frontiers in Nanotechnology · doi:10.3389/fnano.2023.1216921 · Cited by 92
Remya, A. S., Ramesh, M., Saravanan, M., Poopal, R.-K., Bharathi, S., & Nataraj, D. (2014) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2014.11.002 · Cited by 91
Deng, L., Cai, X., Sheng, D., Yang, Y., Strohm, E. M., Wang, Z., Ran, H., Wang, D., Zheng, Y., Li, P., et al. (2017) · Theranostics · doi:10.7150/thno.21283 · Cited by 90
Suciu, M., Ionescu, C. M., Ciorîţă, A., Tripon, S. C., Nica, D. V., Al‐Salami, H., & Barbu–Tudoran, L. (2020) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.11.94 · Cited by 88
Panthi, V. K., Fairfull‐Smith, K. E., & Islam, N. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124046 · Cited by 88
Organ-specific toxicity of magnetic iron oxide-based nanoparticles
Chrishtop, V. V., Mironov, V. A., Prilepskii, A. Y., Nikonorova, V. G., & Vinogradov, V. V. (2021) · Nanotoxicology · doi:10.1080/17435390.2020.1842934 · Cited by 86
Superparamagnetic nanoarchitectures: Multimodal functionalities and applications
Sezer, N., Arı, İ., Biçer, Y., & Koç, M. (2021) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2021.168300 · Cited by 87
Toxicity of Metal and Metal Oxide Nanoparticles
Karlsson, H. L., Toprak, M. S., & Fadeel, B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-59453-2.00004-4 · Cited by 87
Wu, Q., Li, Y., Tang, M. X., & Wang, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043729 · Cited by 86
Gokduman, K. (2016) · Current Drug Targets · doi:10.2174/1389450117666160502151707 · Cited by 84
Magnetic nanoparticles in regenerative medicine: what of their fate and impact in stem cells?
de Walle, A. V., Perez, J. E., Abou‐Hassan, A., Hémadi, M., Luciani, N., & Wilhelm, C. (2020) · Materials Today Nano · doi:10.1016/j.mtnano.2020.100084 · Cited by 83
Bastaki, S., Surendar, A., Saheb, N. A., Kashani, M. A., Dorofeev, A. E., Kiani, F. K., Jahandideh, H., Dargani, F. B., Aksoun, M., Nikkhoo, A., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118847 · Cited by 83
RetractedAhmed, M., Zayed, M. A., El-Dek, S. I., Hady, M. A., Sherbiny, D. H. E., & Uskoković, V. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.026 · Cited by 83
Magnetically Targeted Stem Cell Delivery for Regenerative Medicine
Cores, J., Caranasos, T. G., & Cheng, K. (2015) · Journal of Functional Biomaterials · doi:10.3390/jfb6030526 · Cited by 83
Vrček, I. V., Pongrac, I. M., Pavičić, I., Milić, M., Ahmed, L. B., Babič, M., Horák, D., & Gajović, S. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s102730 · Cited by 83
Nanotechnology-based approach for safer enrichment of semen with best spermatozoa
Durfey, C. L., Swistek, S. E., Liao, S. F., Crenshaw, M. A., Clemente, H. J., Thirumalai, R. V. K. G., Steadman, C. S., Ryan, P. L., Willard, S. T., & Feugang, J. M. (2019) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0307-4 · Cited by 83
Sekar, A. D., Kumar, V., Muthukumar, H., Gopinath, P., & Matheswaran, M. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.05.038 · Cited by 82
Triboulet, S., Aude‐Garcia, C., Carrière, M., Diemer, H., Proamer, F., Habert, A., Chevallet, M., Collin‐Faure, V., Strub, J., Hanau, D., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.030742 · Cited by 82
Farzin, A., Fathi, M., & Emadi, R. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.08.060 · Cited by 82
Yuan, M., Wang, Y., & Qin, Y. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.03.004 · Cited by 81
Al-Musawi, S., Albukhaty, S., Al-Karagoly, H., Sulaiman, G. M., Jabir, M. S., & Naderi‐Manesh, H. (2020) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6254/abc75b · Cited by 80
Ansari, M. A., & Asiri, S. M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.162 · Cited by 80
Samrot, A. V., Ali, H. H., Jenifer Selvarani, A., Faradjeva, E., Raji, P., Prakash, P. R., & Kumar, S. S. (2021) · Current Research in Green and Sustainable Chemistry · doi:10.1016/j.crgsc.2021.100066 · Cited by 80
Carvalho, S. M., Leonel, A. G., Mansur, A. A. P., Carvalho, I. C., Krambrock, K., & Mansur, H. S. (2019) · Biomaterials Science · doi:10.1039/c8bm01528g · Cited by 80
Katebi, S., Esmaeili, A., Ghaedi, K., & Zarrabi, A. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s191878 · Cited by 80
Magnetite nanoparticles effects on adverse responses of aquatic and terrestrial animal models
Kaloyianni, M. G., Dimitriadi, A., Ovezik, M., Stamkopoulou, D., Feidantsis, K. G., Kastrinaki, G., Gallios, G. P., Tsiaoussis, I., Koumoundouros, G., & Bobori, D. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121204 · Cited by 79
Effect of humic acid source on humic acid adsorption onto titanium dioxide nanoparticles
Erhayem, M., & Sohn, M. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.09.063 · Cited by 79
Pelclová, D., Ždı́mal, V., Kačer, P., Fenclová, Z., Vlčková, Š., Syslová, K., Navrátil, T., Schwarz, J., Zíková, N., Barošová, H., et al. (2016) · Journal of Breath Research · doi:10.1088/1752-7155/10/1/016004 · Cited by 79
Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
Jasmin, Souza, G. T., Andrade Louzada, R., Rosado-de-Castro, P. H., Mendez-Otero, R., & Carvalho, A. C. C. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s126530 · Cited by 78
Magnetic systems for cancer immunotherapy
Day, N. B., Wixson, W. C., & Shields, C. W. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.023 · Cited by 79
Iron metabolism: a double-edged sword in the resistance of glioblastoma to therapies
Legendre, C., & Garcion, E. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.008 · Cited by 78
Frantellizzi, V., Conte, M., Pontico, M., Pani, A., Pani, R., & Vincentis, G. D. (2020) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-020-00635-w · Cited by 78
Recent developments and applications of smart nanoparticles in biomedicine
Campora, S., & Ghersi, G. (2022) · Nanotechnology Reviews · doi:10.1515/ntrev-2022-0148 · Cited by 77
Superparamagnetic iron-doped nanocrystalline apatite as a delivery system for doxorubicin
Iafisco, M., Drouet, C., Adamiano, A., Pascaud-Mathieu, P., Montesi, M., Panseri, S., Sarda, S., & Tampieri, A. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01524c · Cited by 77
Ahamed, M., Akhtar, M. J., Khan, M. A. M., Alhadlaq, H. A., & Alshamsan, A. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.09.047 · Cited by 77
Qualhato, G., Rocha, T. L., Lima, E. C. D. O., Silva, D. D. M. E., Cardoso, J. R., Grisólia, C. K., & de Sabóia‐Morais, S. M. T. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.05.061 · Cited by 77
Multifunctional Biodegradable Microrobot with Programmable Morphology for Biomedical Applications
Go, G., Yoo, A., Song, H.-W., Min, H.-K., Zheng, S., Nguyen, K. T., Kim, S., Kang, B., Hong, A., Kim, C., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c07954 · Cited by 76
Chang, Y., Liu, Y., Ho, J. H., Hsu, S., & Lee, O. K. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22088 · Cited by 76
Blood-brain Barrier Crossing using Magnetic Stimulated Nanoparticles
Chen, J., Yuan, M., Madison, C. A., Eitan, S., & Wang, Y. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.007 · Cited by 75
Park, Y. C., Smith, J. B., Pham, T. A., Whitaker, R. D., Sucato, C. A., Hamilton, J. A., Bartolak‐Suki, E., & Wong, J. Y. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.04.027 · Cited by 75
Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting
Plissonneau, M., Pansieri, J., Heinrich, L., Morfin, J., Stransky-Heilkron, N., Rivory, P., Mowat, P., Dumoulin, M., Cohen, R., Allémann, É., et al. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0212-y · Cited by 74
Iron-based magnetic nanomaterials: Sustainable approaches of synthesis and applications
Revathy, R., Sajini, T., Augustine, C., & Joseph, N. (2023) · Results in Engineering · doi:10.1016/j.rineng.2023.101114 · Cited by 74
Neamah, S. A., Albukhaty, S., Falih, I. Q., Dewir, Y. H., & Mahood, H. B. (2023) · Applied Sciences · doi:10.3390/app13116604 · Cited by 74
Iron Oxide as an Mri Contrast Agent for Cell Tracking: Supplementary Issue
Korchinski, D. J., Taha, M., Yang, R., Nathoo, N., & Dunn, J. F. (2015) · Magnetic Resonance Insights · doi:10.4137/mri.s23557 · Cited by 74
Vismara, E., Bongio, C., Coletti, A., Edelman, R., Serafini, A., Mauri, M., Simonutti, R., Bertini, S., Urso, E., Assaraf, Y. G., et al. (2017) · Molecules · doi:10.3390/molecules22071030 · Cited by 74
Sekar, A. D., Muthukumar, H., Udaykumar, S., Gopinath, P., & Matheswaran, M. (2017) · Toxicology Research · doi:10.1039/c7tx00093f · Cited by 74
Khorsandi, K., Hosseinzadeh, R., Esfahani, H., Keyvani‐Ghamsari, S., & Rahman, S. U. (2021) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2021.1908125 · Cited by 73
Adamiano, A., Iafisco, M., Sandri, M., Basini, M., Arosio, P., Canu, T., Sitia, G., Esposito, A., Iannotti, V., Ausanio, G., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.040 · Cited by 71
Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases
Tomitaka, A., Kaushik, A. K., Kevadiya, B. D., Mukadam, I. Z., Gendelman, H. E., Khalili, K., Liu, G., & Nair, M. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.01.006 · Cited by 71
Carreira, S. C., Walker, L. A., Paul, K. B., & Saunders, M. (2013) · Nanotoxicology · doi:10.3109/17435390.2013.833317 · Cited by 71
Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs
Mokhodoeva, O. B., Vlk, M., Málková, E., Kukleva, E., Mičolová, P., Štamberg, K., Šlouf, M., Dzhenloda, R. K., & Kozempel, J. (2016) · Journal of Nanoparticle Research · doi:10.1007/s11051-016-3615-7 · Cited by 70
Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine
Alavi, A. A., Werner, T. J., Stępień, E. Ł., & Moskal, P. (2021) · Bio-Algorithms and Med-Systems · doi:10.1515/bams-2021-0186 · Cited by 69
Drug Delivery to the Brain: Recent Advances and Unmet Challenges
Bhunia, S., Kolishetti, N., Vashist, A., Yndart, A., Brooks, D., & Nair, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122658 · Cited by 71
Metadata
- Authors
- Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H.
- Affiliations
- Swansea University (GB)
- Cardiff University (GB)
- Corresponding author
- Singh, Neenu
- Venue
- Nano Reviews
- Publisher
- Informa UK Limited
- Published
- 2010-01-01
- Volume
- 1
- Issue
- 1
- Pages
- 5358
- ISSN
- 2000-5121 (ISSN-L)
- PMC
- PMC3215220
- OpenAlex
- W2045080998
- Cited by
- 1,112
- References
- 107
- Citations by year
- 2026: 30 · 2025: 63 · 2024: 69 · 2023: 70 · 2022: 87 · 2021: 109 · 2020: 91 · 2019: 78 · 2018: 92 · 2017: 83 · 2016: 83 · 2015: 92 · 2014: 57 · 2013: 60 · 2012: 33
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Nano Reviews (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, nanoparticle toxicity, cytotoxicity, DNA damage, oxidative stress, actin cytoskeleton, gene expression profiling, iron homeostasis, signaling pathways, cell cycle regulation, nanoparticle-protein interactions, surface coating, MRI contrast agents, drug delivery, hyperthermia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
