The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy
Abstract
The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs). Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster self-renewal properties. Different derivation protocols may provide different amounts and populations of stem cells. Stem cell populations have also been reported in other compartments of the umbilical cord, such as the cord lining, perivascular tissue, and Wharton's jelly. HUCMSCs are noncontroversial sources compared to embryonic stem cells. They can differentiate into the three germ layers that promote tissue repair and modulate immune responses and anticancer properties. Thus, they are attractive autologous or allogenic agents for the treatment of malignant and nonmalignant solid and soft cancers. HUCMCs also can be the feeder layer for embryonic stem cells or other pluripotent stem cells. Regarding their therapeutic value, storage banking system and protocols should be established immediately. This review critically evaluates their therapeutic value, challenges, and future directions for their clinical applications.
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Cited by
Ho-Shui-Ling, A., Bolander, J., Rustom, L. E., Johnson, A. W., Luyten, F. P., & Picart, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.017 · Cited by 961
Hu, Q., Lyon, C. J., Fletcher, J. K., Tang, W., Wan, M., & Hu, T. Y. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.014 · Cited by 309
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
Carvalho, C. R., Oliveira, J. M., & Reis, R. L. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00337 · Cited by 297
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297
Xin, L., Lin, X., Pan, Y., Zheng, X., Shi, L., Zhang, Y., Ma, L., Gao, C., & Zhang, S. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.012 · Cited by 201
Metadata
- Authors
- Ding, D.-C., Chang, Y.-H., Shyu, W.-C., & Lin, S.-Z.
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2015-03
- Volume
- 24
- Issue
- 3
- Pages
- 339-347
- ISSN
- 0963-6897 (ISSN-L)
- 1555-3892
- OpenAlex
- W1968323108
- Cited by
- 613
- References
- 72
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ding, D.-C., Chang, Y.-H., Shyu, W.-C., & Lin, S.-Z. (2015). Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy. Cell Transplantation. https://doi.org/10.3727/096368915x686841
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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