Effect of mixture of Lactobacillus plantarum CECT 7527, 7528, and 7529 on obesity and lipid metabolism in rats fed a high-fat diet
Abstract
본 연구에서는 고지방식이 투여로 비만 및 고지혈증을 유도한 동물에서 L. plantarum CECT 7527, 7528과 7529 혼합물이 비만 및 고지혈증에 미치는 영향을 조사하고자 하였다. 흰쥐에 8주 동안 고지방식이를 급여하면서 L. plantarum 혼합물을 0.6~2.4×109 CFU/day를 경구 투여하였고 동물을 희생하여 혈청 및 간조직 내의 지질 함량을 조사하였다. L. plantarum 혼합물 투여에 의해 체중증가량, 간과 부고환지방 무게가 현저히 감소하였다. 또한 비만과 관련 있는 호르몬인 혈청 렙틴의 함량이 L. plantarum 혼합물 투여에 의해 감소하였다. L. plantarum 혼합물 투여가 혈청 중성지방과 HDL-콜레스테롤 함량 및 혈당에는 영향을 미치지 않았으나 혈청 총콜레스테롤 함량 및 LDL-콜레스테롤 함량을 현저히 감소하였다. 이와 더불어 L. plantarum 혼합물 투여가 동맥경화지수와 심혈관위험지수를 유의적으로 감소하였다. 간조직 내의 총 지질 함량, 중성지방 함량 및 총콜레스테롤 함량은 L. plantarum 혼합물 투여에 의해 유의적으로 감소하였다. 이상의 결과는 L. plantarum CECT 7527, 7528과 7529가 혼합된 L. plantarum 혼합물이 체지방 감소 및 고지혈증 개선 효과를 나타냄을 보여준다. 향후 더 많은 연구가 필요하나 본 연구는 L. plantarum 혼합물을 비만 및 고지혈증 개선제로 개발할 수 있는 가능성을 제시한다.
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Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 conform the probiotic formula AB-LIFE, which has shown to reduce total cholesterol and LDL cholesterol in experimental animal studies.
“Lactiplantibacillus plantarum (L. plantarum) strains KABP011, KABP012, and KABP013 conform the probiotic formula AB-LIFE® that has shown to reduce total cholesterol (TC) and LDLc in experimental animal studies.18”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [18]
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“plantarum (approximately 9 log CFU/day/rat) for 8 weeks (Kim et al., 2014).”
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BackgroundUnknown Known: Lactobacillus plantarum. Yesterday, Today, Tomorrow
Никитина, Е. А., Орлова, С. В., Ivanov, S. S., & Orlova, A. A. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-23-21-28
- Authors
- Kim, D. H., Choi, M.-R., Hong, J. E., Lee, J.-Y., Lee, S. I., Jung, S. H., & Kim, E. J.
- Affiliations
- Hallym University (KR)
- Venue
- Journal of the Korean Society of Food Science and Nutrition
- Published
- 2014-10-31
- Volume
- 43
- Issue
- 10
- Pages
- 1484-1490
- ISSN
- 1226-3311 (ISSN-L)
- OpenAlex
- W1819032387
- Cited by
- 5
- References
- 33
- Citations by year
- 2024: 1 · 2021: 1 · 2018: 2 · 2017: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Korean Society of Food Science and Nutrition (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Lactobacillus plantarum, probiotic combination, obesity, hyperlipidemia, high-fat diet, lipid metabolism, hepatic lipid accumulation, leptin, LDL cholesterol, total cholesterol, atherosclerosis, cardiovascular risk, body weight, visceral fat, serum lipids, rats, mice, gut microbiota, dietary protein
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