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Liver zonation: Novel aspects of its regulation and its impact on homeostasis
Open accessAbstract
Liver zonation, the spatial separation of the immense spectrum of different metabolic pathways along the liver sinusoids, is fundamental for proper functioning of this organ. Recent progress in elucidating localization and interactions of different metabolic pathways by using "omics" techniques and novel approaches to couple them with refined spatial resolution and in characterizing novel master regulators of zonation by using transgenic mice has created the basis for a deeper understanding of core mechanisms of zonation and their impact on liver physiology, pathology and metabolic diseases. This review summarizes the fascinating technical achievements for investigating liver zonation and the elucidation of an emerging network of master regulators of zonation that keep the plethora of interrelated and sometimes opposing functions of the liver in balance with nutritional supply and specific requirements of the entire body. In addition, a brief overview is given on newly described zonated functions and novel details on how diverse the segmentation of metabolic zonation may be. From these facts and developments a few fundamental principles are inferred which seem to rule zonation of liver parenchyma. In addition, we identify important questions that still need to be answered as well as interesting fields of research such as the connection of zonation with circadian rhythm and gender dimorphism which need to be pushed further, in order to improve our understanding of metabolic zonation. Finally, an outlook is given on how disturbance of liver zonation and its regulation may impact on liver pathology and the development of metabolic diseases.
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“In vivo, hepatocytes are situated in a highly organized lobular architecture and dynamically interact with a complex extracellular matrix (ECM) of collagens, laminins and fibronectin [14].”
From The Hepatocyte Expansion Paradox: A Review of In Vitro Challenges and Advances (2026) · cites this paper as [14]
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“The absence of paracrine and juxtacrine connections in monoculture systems exacerbates hepatocyte survival and growth potential [14].”
From The Hepatocyte Expansion Paradox: A Review of In Vitro Challenges and Advances (2026) · cites this paper as [14]
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“The failure to recapitulate the complexity of the hepatic environment is a major contributor to hepatocyte dedifferentiation.”
From The Hepatocyte Expansion Paradox: A Review of In Vitro Challenges and Advances (2026) · cites this paper as [14]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
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“When hepatocytes are maintained in vitro, however, this environment is simplified by using conventional culture substrates, leading to dysregulated integrin signaling and accelerated functional decline [14].”
From The Hepatocyte Expansion Paradox: A Review of In Vitro Challenges and Advances (2026) · cites this paper as [14]
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Cites
Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal
Ndiaye, M., Lespez, L., Tribolo, C., Rassé, M., Hadjas, I., Davidoux, S., Huysecom, É., & Douze, K. (2024) · Monash University Research Portal (Monash University) · doi:10.3929/ethz-b-000667478 · Cited by 24,214
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature · doi:10.1038/nature11826 · Cited by 1,555
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor
Montesano, R., Matsumoto, K., Nakamura, T., & Orci, L. (1991) · Cell · doi:10.1016/0092-8674(91)90363-4 · Cited by 1,147
Nakamura, T., Nawa, K., & Ichihara, A. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91253-1 · Cited by 1,134
In situ sequencing for RNA analysis in preserved tissue and cells
Ke, R., Mignardi, M., Pacureanu, A., Svedlund, J., Botling, J., Wählby, C., & Nilsson, M. (2013) · Nature Methods · doi:10.1038/nmeth.2563 · Cited by 934
Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
Waxman, D. J., & Holloway, M. G. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056705 · Cited by 815
Morphogen gradient interpretation
Gurdon, J. B., & Bourillot, P.-Y. (2001) · Nature · doi:10.1038/35101500 · Cited by 746
A QUANTITATIVE STEREOLOGICAL DESCRIPTION OF THE ULTRASTRUCTURE OF NORMAL RAT LIVER PARENCHYMAL CELLS
Loud, A. V. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.37.1.27 · Cited by 727
An atlas of combinatorial transcriptional regulation in mouse and man
Ravasi, T., Suzuki, H., Cannistraci, C. V., Katayama, S., Bajic, V. B., Tan, K., Akalin, A., Schmeier, S., Kanamori-Katayama, M., Bertin, N., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.044 · Cited by 715
Roberts, M. S., Magnusson, B. M., Burczynski, F. J., & Weiß, M. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241100-00005 · Cited by 684
Emerging Multipotent Aspects of Hepatocyte Growth Factor
Matsumoto, K., & Nakamura, T. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021283 · Cited by 666
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658
Metabolic zonation of the liver: Regulation and implications for liver function
Gebhardt, R. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90055-5 · Cited by 607
Self-citationZonation of parenchymal and nonparenchymal metabolism in liver.
Jungermann, K., & Keitzmann, T. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001143 · Cited by 589
The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.
Zarnegar, R., & Michalopoulos, G. K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.5.1177 · Cited by 569
Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver
Benhamouche, S., Decaens, T., Godard, C., Chambrey, R., Rickman, D. S., Moinard, C., Vasseur-Cognet, M., Kuo, C. J., Kahn, A., Perret, C., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.015 · Cited by 543
The interpretation of morphogen gradients
Ashe, H. L., & Briscoe, J. (2006) · Development · doi:10.1242/dev.02238 · Cited by 493
Hepatocyte growth factor twenty years on: Much more than a growth factor
Nakamura, T., Sakai, K., Nakamura, T., & Matsumoto, K. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06549.x · Cited by 472
WNT/β‐catenin signaling in liver health and disease
Thompson, M. D., & Monga, S. P. (2007) · Hepatology · doi:10.1002/hep.21651 · Cited by 472
Morphogens, their identification and regulation
Tabata, T., & Takei, Y. (2004) · Development · doi:10.1242/dev.01043 · Cited by 447
Oxygen: Modulator of metabolic zonation and disease of the liver
Jungermann, K., & Kietzmann, T. (2000) · Hepatology · doi:10.1002/hep.510310201 · Cited by 443
Pessayre, D., & Fromenty, B. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.03.004 · Cited by 441
New targets of β-catenin signaling in the liver are involved in the glutamine metabolism
Cadoret, A., Ovejero, C., Terris, B., Souil, E., Lévy, L., Lamers, W. H., Kitajewski, J., Kahn, A., & Perret, C. (2002) · Oncogene · doi:10.1038/sj.onc.1206118 · Cited by 412
Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?
Mulholland, D. J., Dedhar, S., Coetzee, G. A., & Nelson, C. C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0034 · Cited by 377
Gebhardt, R., & Mecke, D. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01464.x · Cited by 377
Self-citationCauchi, S., Achhab, Y. E., Choquet, H., Christian Dina, C., Krempler, F., Weitgasser, R., Nejjari, C., Patsch, W., Chikri, M., Meyre, D., et al. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0203-4 · Cited by 372
The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
Wang, Y., Ding, Q., Yen, C.-J., Xia, W., Izzo, J. G., Lang, J.-Y., Li, C., Hsu, J. L., Miller, S. A., Wang, X., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.12.028 · Cited by 351
Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.
Truica, C. I., Byers, S. W., & Gelmann, E. P. (2000) · PubMed · Cited by 346
Reduced insulin/IGF‐1 signalling and human longevity
van Heemst, D., Beekman, M., Mooijaart, S. P., Heijmans, B. T., Brandt, B. W., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00148.x · Cited by 338
Morphogen Gradient FormationPreprint
Wartlick, O., Kicheva, A., & González‐Gaitán, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001255 · Cited by 296
Sekine, S., Lan, B. Y., Bedolli, M., Feng, S., & Hebrok, M. (2006) · Hepatology · doi:10.1002/hep.21131 · Cited by 295
Changes in Wnt/β–Catenin Pathway During Regulated Growth in Rat Liver Regeneration
Monga, S. P. S., Pediaditakis, P., Mule, K., Stolz, D. B., & Michalopoulos, G. K. (2001) · Hepatology · doi:10.1053/jhep.2001.23786 · Cited by 292
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
Sicklick, J. K., Li, Y.-X., Jayaraman, A., Kannangai, R., Qi, Y. P., Vivekanandan, P., Ludlow, J. W., Owzar, K., Chen, W., Torbenson, M. S., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi292 · Cited by 276
Differential gene expression in periportal and perivenous mouse hepatocytes
Braeuning, A., Ittrich, C., Köhle, C., Hailfinger, S., Bonin, M., Buchmann, A., & Schwarz, M. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05503.x · Cited by 240
Hepatocyte Heterogeneity in the Metabolism of Amino Acids and Ammonia
Häussinger, D., Lames, W. H., & Moorman, A. F. M. (2017) · Enzyme · doi:10.1159/000468779 · Cited by 229
Heterogeneity of liver parenchymal cells
Jungermann, K. A., & Sasse, D. (1978) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(78)91764-4 · Cited by 221
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
Yang, L., Wang, Y., Mao, H., Fleig, S. V., Omenetti, A., Brown, K. D., Sicklick, J. K., Li, Y., & Diehl, A. M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.07.032 · Cited by 204
Redox Control of Liver Function in Health and Disease
Marí, M., Colell, A., Morales, A., von Montfort, C., García‐Ruiz, C., & Fernández-Checa, J. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2634 · Cited by 203
Increased production of sonic hedgehog by ballooned hepatocytes
Rangwala, F., Guy, C. D., Lu, J., Suzuki, A., Burchette, J. L., Abdelmalek, M. F., Chen, W., & Diehl, A. M. (2011) · The Journal of Pathology · doi:10.1002/path.2888 · Cited by 201
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Pajvani, U. B., Shawber, C. J., Samuel, V. T., Birkenfeld, A. L., Shulman, G. I., Kitajewski, J., & Accili, D. (2011) · Nature Medicine · doi:10.1038/nm.2378 · Cited by 193
Hedgehog Signaling Is Critical for Normal Liver Regeneration After Partial Hepatectomy in Mice
Ochoa, B., Syn, W., Delgado, I., Karaca, G., Jung, Y., Wang, J., Zubiaga, A. M., Fresnedo, O., Omenetti, A., Zdanowicz, M., et al. (2010) · Hepatology · doi:10.1002/hep.23525 · Cited by 190
Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences
Hijmans, B. S., Grefhorst, A., Oosterveer, M. H., & Groen, A. K. (2013) · Biochimie · doi:10.1016/j.biochi.2013.06.007 · Cited by 184
Role for Hedgehog Signaling in Hepatic Stellate Cell Activation and Viability
Sicklick, J. K., Li, Y.-X., Choi, S. S., Qi, Y., Chen, W., Bustamante, M., Huang, J., Zdanowicz, M., Camp, T., Torbenson, M. S., et al. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700349 · Cited by 179
Pajvani, U. B., Qiang, L., Kangsamaksin, T., Kitajewski, J., Ginsberg, H. N., & Accili, D. (2013) · Nature Medicine · doi:10.1038/nm.3259 · Cited by 172
In Situ Lipidomic Analysis of Nonalcoholic Fatty Liver by Cluster TOF-SIMS Imaging
Debois, D., Bralet, M., Naour, F. L., Brunelle, A., & Laprévôte, O. (2009) · Analytical Chemistry · doi:10.1021/ac900045m · Cited by 168
Liver Zonation Occurs Through a β-Catenin–Dependent, c-Myc–Independent Mechanism
Burke, Z. D., Reed, K. R., Phesse, T. J., Sansom, O. J., Clarke, A. R., & Tosh, D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.063 · Cited by 163
Casanovas, G., Mleczko-Sanecka, K., Altamura, S., Hentze, M. W., & Muckenthaler, M. U. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0447-2 · Cited by 161
Metabolic Zonation of Liver Parenchyma
Jungermann, K. A. (1988) · Seminars in Liver Disease · doi:10.1055/s-2008-1040554 · Cited by 151
Zonal gene expression in murine liver: Lessons from tumors
Hailfinger, S., Jaworski, M., Braeuning, A., Buchmann, A., & Schwarz, M. (2006) · Hepatology · doi:10.1002/hep.21082 · Cited by 149
Hepatic enzymic zonation: A reevaluation of the concept of the liver acinus
Lamers, W. H., Hilberts, A., Furt, E., Smith, J. D., Jonges, G. N., Noorden, C. J. F. V., Janzen, J. W. G., Charles, R., & Moorman, A. F. M. (1989) · Hepatology · doi:10.1002/hep.1840100115 · Cited by 147
Wnt'er in liver: Expression of Wnt and frizzled genes in mouse
Zeng, G., Awan, F. T., Otruba, W., Stock, P., Apte, U. M., Tan, X., Gandhi, C. R., Demetris, A. J., & Monga, S. P. (2006) · Hepatology · doi:10.1002/hep.21473 · Cited by 146
Nuclear architecture and gene regulation
Fedorova, E., & Zink, D. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.07.018 · Cited by 146
Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver
Lindros, K. O. (1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(96)00183-8 · Cited by 145
Convergence of Wnt Signaling on the HNF4α-Driven Transcription in Controlling Liver Zonation
Colletti, M., Cicchini, C., Conigliaro, A., Santangelo, L., Alonzi, T., Pasquini, E., Tripodi, M., & Amicone, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.038 · Cited by 145
Gebhardt, R., Baldysiak-Figiel, A., Krügel, V., Ueberham, E., & Gaunitz, F. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2006.12.001 · Cited by 131
Self-citationFetal hepatic drug elimination
Ring, J. A., Ghabrial, H., Ching, M. S., Smallwood, R. A., & Morgan, D. J. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00046-7 · Cited by 129
Austinat, M., Dunsch, R., Wittekind, C., Tannapfel, A., Gebhardt, R., & Gaunitz, F. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-21 · Cited by 128
Self-citationActions and Mode of Actions of FGF19 Subfamily Members
Fukumoto, S. (2008) · Endocrine Journal · doi:10.1507/endocrj.kr07e-002 · Cited by 125
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Mleczko‐Sanecka, K., Casanovas, G., Ragab, A., Breitkopf, K., Müller, A., Boutros, M., Dooley, S., Hentze, M. W., & Muckenthaler, M. U. (2009) · Blood · doi:10.1182/blood-2009-09-238105 · Cited by 124
Liver Microvascular Architecture: An Insight into the Pathophysiology of Portal Hypertension
Ekataksin, W., & Kaneda, K. (1999) · Seminars in Liver Disease · doi:10.1055/s-2007-1007126 · Cited by 121
(2002) · PubMed · Cited by 120
Self-citationHepatocyte Heterogeneity in the Metabolism of Carbohydrates
Jungermann, K. A., & Thurman, R. G. (2017) · Enzyme · doi:10.1159/000468777 · Cited by 118
Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease
Valenti, L. V. C., Mendoza, R. M., Rametta, R., Maggioni, M., Kitajewski, C., Shawber, C. J., & Pajvani, U. B. (2013) · Diabetes · doi:10.2337/db13-0769 · Cited by 113
Lu, Y., Jin, T., Xu, Y.-S., Zhang, D., Wu, Q., Zhang, Y.-K. J., & Liu, J. (2013) · Chronobiology International · doi:10.3109/07420528.2013.805762 · Cited by 112
Inhibition of hepcidin transcription by growth factors
Goodnough, J. B., Ramos, E., Nemeth, E., & Ganz, T. (2012) · Hepatology · doi:10.1002/hep.25615 · Cited by 108
Torre, C., Perret, C., & Colnot, S. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.004 · Cited by 106
Gebhardt, R., & Hovhannisyan, A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22041 · Cited by 104
Self-citationBur, I. M., Cohen-Solal, A., Carmignac, D. F., Abécassis, P.-Y., Chauvet, N., Martin, A., van der Horst, G. T. J., Robinson, I. C. A. F., Maurel, P., Mollard, P., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808360200 · Cited by 103
β-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice
Lehwald, N., Tao, G., Jang, K. Y., Papandreou, I., Liu, B., Liu, B., Pysz, M. A., Willmann, J. K., Knoefel, W. T., Denko, N. C., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.048 · Cited by 102
Wnt/β-Catenin Pathway in Hepatocellular Carcinoma Pathogenesis and Liver Physiology
Cavard, C., Colnot, S., Audard, V., Benhamouche, S., Finzi, L., Torre, C., Grimber, G., Godard, C., Terris, B., & Perret, C. (2008) · Future Oncology · doi:10.2217/14796694.4.5.647 · Cited by 94
Regulation of hepatic ammonia metabolism: The intercellular glutamine cycle
Häussinger, D. (1986) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(86)90013-0 · Cited by 90
Should I stay or should I go: β-catenin decides under stress
Hoogeboom, D., & Burgering, B. M. T. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.02.002 · Cited by 90
Chafey, P., Finzi, L., Boisgard, R., Caüzac, M., Clary, G., Broussard, C., Pégorier, J., Guillonneau, F., Mayeux, P., Camoin, L., et al. (2009) · Proteomics · doi:10.1002/pmic.200800609 · Cited by 90
The Wnt/β-catenin signaling pathway in liver biology and disease
Behari, J. (2010) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.74 · Cited by 90
Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis
Wattacheril, J. J., Seeley, E. H., Angel, P. M., Chen, H., Bowen, B. P., Lanciault, C., Caprioli, R. M., Abumrad, N. N., & Flynn, C. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057165 · Cited by 88
The transcriptomic signature of fasting murine liver
Sokolović, M., Sokolović, A., Wehkamp, D., van Themaat, E. V. L., de Waart, D. R., Gilhuijs-Pederson, L. A., Nikolsky, Y., van Kampen, A. H. C., Hakvoort, T. B. M., & Lamers, W. H. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-528 · Cited by 88
Wnt-signalling and the Metabolic Syndrome
Schinner, S. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0028-1119408 · Cited by 87
Montfort, C. V., Matias, N., Fernandez, A., Fucho, R., de la Rosa, L. C., Martinez-Chantar, M. L., Mato, J. M., Machida, K., Tsukamoto, H., Murphy, M. P., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.05.024 · Cited by 83
Stanulović, V. S., Kyrmizi, I., Julio, M. K., Hoogenkamp, M., Vermeulen, J. L. M., Ruijter, J. M., Talianidis, I., Hakvoort, T. B. M., & Lamers, W. H. (2007) · Hepatology · doi:10.1002/hep.21456 · Cited by 80
Hedgehog signaling in cholangiocytes
Omenetti, A., & Diehl, A. M. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834550b4 · Cited by 77
Sasse, D. (1975) · Histochemistry and Cell Biology · doi:10.1007/bf00507698 · Cited by 77
Underlying potential: cellular and molecular determinants of adult liver repair
Diehl, A. M., & Chute, J. P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69966 · Cited by 72
Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations
Comar, J. F., Suzuki‐Kemmelmeier, F., Constantin, J., & Bracht, A. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-1 · Cited by 71
Microphotometric studies on intraacinar enzyme distribution in rat liver
Wimmer, M., & Pette, D. (1979) · Histochemistry and Cell Biology · doi:10.1007/bf00493352 · Cited by 69
Reed, K. R., Athineos, D., Méniel, V. S., Wilkins, J. A., Ridgway, R. A., Burke, Z. D., Muncan, V., Clarke, A. R., & Sansom, O. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805778105 · Cited by 67
Tosh, D., Alberti, K. G. M. M., & Agius, L. (1988) · Biochemical Journal · doi:10.1042/bj2560197 · Cited by 67
The Wnt/β-catenin pathway: master regulator of liver zonation?
Burke, Z. D., & Tosh, D. (2006) · BioEssays · doi:10.1002/bies.20485 · Cited by 66
Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields
Guardavaccaro, D., & Clevers, H. C. (2012) · Science Signaling · doi:10.1126/scisignal.2002921 · Cited by 66
Giera, S., Braeuning, A., Köhle, C., Bursch, W., Metzger, U., Buchmann, A., & Schwarz, M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq033 · Cited by 66
A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes
Kakisaka, K., Cazanave, S. C., Werneburg, N. W., Razumilava, N., Mertens, J. C., Bronk, S. F., & Gores, G. J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.05.011 · Cited by 65
Moriyama, A., Kii, I., Sunabori, T., Kurihara, S., Takayama, I., Shimazaki, M., Tanabe, H., Oginuma, M., Fukayama, M., Matsuzaki, Y., et al. (2007) · genesis · doi:10.1002/dvg.20268 · Cited by 64
Pleiotropic effects of growth hormone signaling in aging
Bartke, A. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.07.004 · Cited by 62
Zou, Z., Ekataksin, W., & Wake, K. (1998) · Hepatology · doi:10.1002/hep.510270427 · Cited by 60
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
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Self-citationQuistorff, B., & Grunnet, N. (1987) · Biochemical Journal · doi:10.1042/bj2430087 · Cited by 59
Liu, S., Yeh, T.-H., Singh, V. P., Shiva, S., Krauland, L., Li, H., Zhang, P., Kharbanda, K., Ritov, V., Monga, S. P. S., et al. (2012) · Hepatology · doi:10.1002/hep.24766 · Cited by 59
Glutamine metabolism links growth factor signaling to the regulation of autophagy
van der Vos, K. E., & Coffer, P. J. (2012) · Autophagy · doi:10.4161/auto.22152 · Cited by 58
Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice
Lorbek, G., Perše, M., Horvat, S., Björkhem, I., & Rozman, D. (2013) · Molecules · doi:10.3390/molecules180911067 · Cited by 58
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Schmutz, I., Albrecht, U., & Ripperger, J. A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.007 · Cited by 56
Zonal distribution of transcripts of four hepatic transcription factors in the mature rat liver
Lindros, K. O., Oinonen, T., Issakainen, J., Nagy, P., & Thorgeirsson, S. S. (1997) · Cell Biology and Toxicology · doi:10.1023/a:1007479223229 · Cited by 47
The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin.
Louro, I. D., McKie-Bell, P., Gosnell, H., Brindley, B. C., Bucy, R. P., & Ruppert, J. M. (1999) · PubMed · Cited by 44
Braeuning, A., Ittrich, C., Köhle, C., Buchmann, A., & Schwarz, M. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.013656 · Cited by 42
Kaibori, M., Ah, K., Oda, M., Kamiyama, Y., Kitamura, N., & Okumura, T. (1998) · Hepatology · doi:10.1002/hep.510270523 · Cited by 42
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Self-citationGebhardt, R., Gaunitz, F., & Mecke, D. (1994) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(94)90007-8 · Cited by 41
Self-citationBraeuning, A., Heubach, Y., Knorpp, T., Kowalik, M. A., Templin, M., Columbano, A., & Schwarz, M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr166 · Cited by 40
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Matz‐Soja, M., Hovhannisyan, A., & Gebhardt, R. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.01.032 · Cited by 36
Self-citationSexual dimorphisms in zonal gene expression in mouse liver
Saito, K., Negishi, M., & James Squires, E. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.025 · Cited by 36
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Hirao, J., Nishimura, M., Arakawa, S., Niino, N., Mori, K., Furukawa, T., Sanbuissho, A., Manabe, S., Nishihara, M., & Mori, Y. (2011) · The Journal of Toxicological Sciences · doi:10.2131/jts.36.9 · Cited by 34
Development of complementary expression patterns of E‐ and N‐cadherin in the mouse liver
Doi, Y., Tamura, S., Nammo, T., Fukui, K., Kiso, S., & Nagafuchi, A. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00028.x · Cited by 34
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Matsumoto, K., & Nakamura, T. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515457.ch13 · Cited by 34
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Braeuning, A. (2009) · Current Drug Metabolism · doi:10.2174/138920009787522160 · Cited by 31
Sirma, H., Williams, G. M., & Gebhardt, R. (1996) · Liver International · doi:10.1111/j.1600-0676.1996.tb00723.x · Cited by 30
Self-citationNeighborhood watch orchestrates liver regeneration
Diehl, A. M. (2012) · Nature Medicine · doi:10.1038/nm.2719 · Cited by 29
Ando, H., Takamura, T., Nagata, N., Shima, K. R., Nakamura, S., Kumazaki, M., Kurita, S., Misu, H., Togawa, N., Fukushima, T., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.150 · Cited by 27
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Jung, Y., & Diehl, A. M. (2010) · Digestive Diseases · doi:10.1159/000282092 · Cited by 26
Lenart, J., Dombrowski, F., Görlach, A., & Kietzmann, T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.02.007 · Cited by 24
Massimi, M., Lear, S. R., Williams, D. L., Jones, A. L., & Erickson, S. K. (1999) · Hepatology · doi:10.1002/hep.510290504 · Cited by 22
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Braeuning, A., & Schwarz, M. (2010) · Biological Chemistry · doi:10.1515/bc.2010.115 · Cited by 21
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Lauth, M. (2011) · Frontiers in bioscience · doi:10.2741/3852 · Cited by 21
Gebhardt, R., & Coffer, P. J. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-21 · Cited by 17
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Gebhardt, R. (2003) · Humana Press eBooks · doi:10.1385/0-89603-519-0:319 · Cited by 17
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Cooke, J. (1995) · BioEssays · doi:10.1002/bies.950170202 · Cited by 15
Imai, K., Mine, T., Tagami, M., Hanaoka, K., & Fujita, T. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1394 · Cited by 12
Regulation of hepatic metabolism: Intra and intercellular compartmentation.
Henley, K. S. (1987) · Hepatology · doi:10.1002/hep.1840070243 · Cited by 10
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Metadata
- Authors
- Gebhardt, R.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Gebhardt, Rolf
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 26
- Pages
- 8491
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4093700
- OpenAlex
- W2013232839
- Cited by
- 275
- References
- 132
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 19 · 2023: 25 · 2022: 30 · 2021: 29 · 2020: 24 · 2019: 40 · 2018: 28 · 2017: 23 · 2016: 18 · 2015: 11 · 2014: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- liver zonation, metabolic zonation, liver parenchyma, liver homeostasis, hepatic metabolism, metabolic disorders, liver pathology, circadian rhythm, sex differences, transgenic mice
- MeSH terms
- Animals, Biotransformation, Energy Metabolism, Homeostasis, Humans, Liver, Liver Diseases, Signal Transduction
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