NASH: a mitochondrial disease

Pessayre, Dominique; Fromenty, Bernard

doi:10.1016/j.jhep.2005.03.004

Cited by 441Liver Disease Diagnosis and TreatmentMitochondrial Function and PathologyDiet, Metabolism, and Disease

NASH: a mitochondrial disease

Pessayre, Dominique, Fromenty, Bernard·2005·Journal of Hepatology

DOI 10.1016/j.jhep.2005.03.004

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A lack of oxidative capacity to handle excess fatty acids delivered to the liver in obesity may have an important role in NAFLD progression accompanied by insulin resistance.
“It is likely that the lack of oxidative capacity to overcome the excess fatty acids that are transported to the liver during conditions such as obesity might have a vital role in the progression of NAFLD accompanied by insulin resistance159.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [159]

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Authors: Pessayre, D., & Fromenty, B.
Affiliations: Inserm (FR)
Corresponding author: Pessayre, Dominique
ORCID: Fromenty, Bernard
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2005-06
Volume: 42
Issue: 6
Pages: 928-940
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2005.03.004
OpenAlex: W2022657181
Cited by: 441
References: 123
Citations by year: 2026: 9 · 2025: 14 · 2024: 17 · 2023: 19 · 2022: 27 · 2021: 33 · 2020: 25 · 2019: 20 · 2018: 29 · 2017: 21 · 2016: 11 · 2015: 19 · 2014: 26 · 2013: 20 · 2012: 19
FWCI: 14.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: nonalcoholic steatohepatitis, mitochondrial disease, obesity, mitochondrial dysfunction, fat deposition, energy expenditure
MeSH terms: Animals, Fatty Liver, Humans, Mitochondrial Diseases

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