Cited by 175Gut microbiota and healthOral microbiology and periodontitis researchGenetic factors in colorectal cancer

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Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients

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Li, Yu-Yuan, Ge, Quan-Xing, Cao, Jie, Zhou, Yong-Jian, Du, Yan-Lei, Shen, Bo, Wan, Yu-Jui Yvonne, Nie, Yu-Qiang·2016·World Journal of Gastroenterology

DOI 10.3748/wjg.v22.i11.3227PMC PMC4789998

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Abstract

AIM: To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS: The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent quantitative polymerase chain reaction (FQ-PCR) was applied to detect F. nucleatum in CRC and normal tissues. The difference of F. nucleatum abundance between cancer and normal tissues and the relationship of F. nucleatum abundance with clinical variables were evaluated. Fluorescence in situ hybridization (FISH) analysis was performed on 22 CRC tissues with the highest F. nucleatum abundance by FQ-PCR testing to confirm FQ-PCR results. RESULTS: The median abundance of F. nucleatum in CRC tissues [0.242 (0.178-0.276)] was significantly higher than that in normal controls [0.050 (0.023-0.067)] (P < 0.001). F. nucleatum was over-represented in 88/101 (87.1%) CRC samples. The abundance of F. nucleatum determined by 2(-ΔCT) was significantly greater in tumor samples [0.242 (0.178, 0.276)] than in normal controls [0.050 (0.023, 0.067)] (P < 0.001). The frequency of patients with lymph node metastases was higher in the over-abundance group [52/88 (59.1%)] than in the under-abundance group [0/13 (0%)] (P < 0.005). No significant association of F. nucleatum with other clinico-pathological variables was observed (P > 0.05). FISH analysis also found more F. nucleatum in CRC than in normal tissues (median number 6, 25(th) 3, 75(th) 10 vs 2, 25(th) 1, 75(th) 5) (P < 0.01). CONCLUSION: F. nucleatum was enriched in CRC tissues and associated with CRC development and metastasis.

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Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077
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Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
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Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
The global health burden of infection‐associated cancers in the year 2002
Parkin, D. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.21731 · Cited by 2,932
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Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
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Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
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Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
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Chen, Y., Lu, Y., Ke, Y., & Li, Y. (2019) · Medicine · doi:10.1097/md.0000000000017221 · Cited by 42
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Zhang, Y., Niu, Q., Fan, W., Huang, F. P., & He, H. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s194153 · Cited by 39
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Authors: Li, Y.-Y., Ge, Q.-X., Cao, J., Zhou, Y.-J., Du, Y.-L., Shen, B., Wan, Y.-J. Y., & Nie, Y.-Q.
Affiliations: Guangzhou First People's Hospital (CN)
ORCID: Ge, Quan-Xing
Cao, Jie
Shen, Bo
Wan, Yu-Jui Yvonne
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2016
Volume: 22
Issue: 11
Pages: 3227
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v22.i11.3227
PMC: PMC4789998
OpenAlex: W2330539438
Cited by: 175
References: 38
Citations by year: 2026: 7 · 2025: 16 · 2024: 11 · 2023: 13 · 2022: 20 · 2021: 26 · 2020: 25 · 2019: 23 · 2018: 22 · 2017: 10 · 2016: 2
FWCI: 9.87
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Guangzhou First People's Hospital
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: Fusobacterium nucleatum, colorectal cancer, gut microbiota, tumor invasion, lymph node metastasis, Chinese patients
MeSH terms: Adult, Aged, Aged, 80 and over, China, DNA, Bacterial, Female, Fusobacterium Infections, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Colorectal Neoplasms, Fusobacterium nucleatum, In Situ Hybridization, Fluorescence, Ribotyping, Asian People, Real-Time Polymerase Chain Reaction

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Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients

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