Gut microbiota in common elderly diseases affecting activities of daily living
Open accessAbstract
Gut microbiota are involved in the development or prevention of various diseases such as type 2 diabetes, fatty liver, and malignancy such as colorectal cancer, breast cancer and hepatocellular carcinoma. Alzheimer's disease, osteoporosis, sarcopenia, atherosclerotic stroke and cardiovascular disease are major diseases associated with decreased activities of daily living (ADL), especially in elderly people. Recent analyses have revealed the importance of gut microbiota in the control of these diseases. The composition or diversity of these microbiota is different between patients with these conditions and healthy controls, and administration of probiotics or prebiotics has been shown effective in the treatment of these diseases. Gut microbiota may affect distant organs through mechanisms that include regulating the absorption of nutrients and/or the production of microbial metabolites, regulating and interacting with the systemic immune system, and translocating bacteria/bacterial products through disrupted mucosal barriers. Thus, the gut microbiota may be important regulators in the development of diseases that affect ADL. Although adequate exercise and proper diet are important for preventing these diseases, their combination with interventions that manipulate the composition and/or diversity of gut microbiota could be a promising strategy for maintaining health condition and preserving ADL. This review thus summarizes current understanding of the role of gut microbiota in the development or prevention of diseases closely associated with the maintenance of ADL.
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The observed landmarks of sarcopenia and physical frailty in the fecal microbiota may simply represent the consequence of reduced physical activity, an epiphenomenon of pathophysiological processes driven by environmental factors.
“From this perspective, the observed landmarks of sarcopenia and physical frailty in the fecal microbiota may simply represent the consequence of reduced physical activity [133], just an epiphenomenon of pathophysiological processes driven by environmental factors [134].”
From Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia (2019) · cites this paper as [133]
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Novel Mechanisms and Therapeutic Targets for Ischemic Stroke: A Focus on Gut Microbiota
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The Role of the Gut Microbiota and the Immune System in the Development of Autism
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Gut Microbiota and Aging: A Broad Perspective
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- Authors
- Shimizu, Y.
- Affiliations
- Nanto Municipal Hospital (JP)
- Corresponding author
- Shimizu, Yukihiro
- ORCID
- Shimizu, Yukihiro
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2018-11-14
- Volume
- 24
- Issue
- 42
- Pages
- 4750-4758
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC6235798
- OpenAlex
- W2900559388
- Cited by
- 40
- References
- 69
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 5
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, activities of daily living, older adults, Alzheimer's disease, osteoporosis, sarcopenia, atherosclerotic stroke, cardiovascular disease, type 2 diabetes, hepatic steatosis, colorectal cancer, breast cancer, hepatocellular carcinoma, probiotics, prebiotics, microbial metabolites, mucosal barrier, physical activity, diet
- MeSH terms
- Gastrointestinal Microbiome, Activities of Daily Living, Aged, Alzheimer Disease, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Neoplasms, Osteoporosis, Probiotics, Stroke, Gastrointestinal Tract, Sarcopenia, Prebiotics, Dysbiosis
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