Microbial Short-Chain Fatty Acids and Blood Pressure Regulation
Open accessAbstract
Purpose of review Microbial short-chain fatty acids (SCFAs) are byproducts of microbial metabolism which can be absorbed into the bloodstream of the host, where they exert effects on host physiology. SCFAs have been known to influence several aspects of host physiology, including the regulation of blood pressure. In this review, we will consider recent studies linking SCFAs to blood pressure regulation.Recent findings Several recent studies have found that changes in blood pressure often coordinate with expected changes in SCFAS. Efforts are now well underway to dissect and better understand this potential connection. One way that SCFAs can influence host cells is by interacting with host GPCRs, including Gpr41 and Olfr78, among others. Intriguingly, mice null for Olfr78 are hypotensive, whereas mice null for Gpr41 are hypertensive, implying that these pathways may be physiologically important links between SCFAs and host blood pressure control. In sum, these studies demonstrate that there does indeed appear to be a link between SCFAs and blood pressure, which likely involves host GPCRs, at least in part; however, the details and intricacies of these interactions are not yet fully understood and will greatly benefit from further studies.
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SCFAs have been implicated in GI function, blood-pressure regulation, circadian rhythm, and (neuro)immune function.
“SCFAs have been implicated in a variety of host processes including GI function (Gill et al., 2018), blood-pressure regulation (Pluznick, 2017), circadian rhythm (Tahara et al., 2018), and (neuro)immune function (Erny et al., 2017)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Pluznick, 2017
Microbial short-chain fatty acids appear to influence blood pressure by interacting with host SCFA receptors.
“It appears microbial SCFAs influence blood pressure by interacting with host SCFA receptors [102].”
From The athletic gut microbiota (2020) · cites this paper as [102]
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- Authors
- Pluznick, J. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Pluznick, Jennifer L.
- Venue
- Current Hypertension Reports
- Published
- 2017-03-17
- Volume
- 19
- Issue
- 4
- Pages
- 25-25
- ISSN
- 1522-6417 (ISSN-L)
- 1534-3111
- PMC
- PMC5584783
- OpenAlex
- W2596501682
- Cited by
- 301
- References
- 36
- Citations by year
- 2026: 21 · 2025: 40 · 2024: 28 · 2023: 37 · 2022: 44 · 2021: 47 · 2020: 40 · 2019: 26 · 2018: 14 · 2017: 3
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Hypertension Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- national institutes of health (R01DK-107726, R01HL-128512,)
- american heart association (16IRG27260265)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- blood pressure regulation, gut microbiota, G protein-coupled receptors, GPR41, host-microbe interactions, hypertension, hypotension, gut-brain axis
- MeSH terms
- Animals, Blood Pressure, Fatty Acids, Volatile, Humans, Hypertension
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