Cited by 493Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology StudiesTreatment of Major Depression

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Neural correlates of rumination in depression

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Cooney, Rebecca E., Joormann, Jutta, Eugène, Fanny, Dennis, Emily L., Gotlib, Ian H.·2010·Cognitive, Affective, & Behavioral Neuroscience

DOI 10.3758/cabn.10.4.470PMC PMC4476645

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Abstract

Rumination, or recursive self-focused thinking, has important implications for understanding the development and maintenance of depressive episodes. Rumination is associated with the worsening of negative mood states, greater affective responding to negative material, and increased access to negative memories. The present study was designed to use fMRI to examine neural aspects of rumination in depressed and healthy control individuals. We used a rumination induction task to assess differences in patterns of neural activation during ruminative self-focus as compared with a concrete distraction condition and with a novel abstract distraction condition in 14 participants who were diagnosed with major depressive disorder and 14 healthy control participants. Depressed participants exhibited increased activation in the orbitofrontal cortex, subgenual anterior cingulate, and dorsolateral prefrontal cortex as compared with healthy controls during rumination versus concrete distraction. Neural activity during rumination versus abstract distraction was greater for depressed than for control participants in the amygdala, rostral anterior cingulate/medial prefrontal cortex, dorsolateral prefrontal cortex, posterior cingulate, and parahippocampus. These findings indicate that ruminative self-focus is associated with enhanced recruitment of limbic and medial and dorsolateral prefrontal regions in depression. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.

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Depressive rumination and heart rate variability: A pilot study on the effect of biofeedback on rumination and its physiological concomitants
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Working it out: can an acute exercise bout alleviate memory bias, rumination and negative mood?
Schmitter, M., Vanderhasselt, M., Spijker, J., Smits, J. A. J., & Vrijsen, J. N. (2023) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2022.2164349 · Cited by 19
“Exercise directly affects the activity in the prefrontal cortex (e.g. Yanagisawa et al., 2010), which is the brain area associated with higher-order cognitions including rumination (Cooney et al., 2010).”
Background
Affective enhancement of working memory is maintained in depression.
Schweizer, S., Navrady, L. B., Breakwell, L., Howard, R. M., Golden, A.-M. J., Werner‐Seidler, A., & Dalgleish, T. (2017) · Emotion · doi:10.1037/emo0000306 · Cited by 17
Prefrontal tDCS attenuates counterfactual thinking in female individuals prone to self-critical rumination
Allaert, J., Raedt, R. D., van der Veen, F. M., Baeken, C., & Vanderhasselt, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90677-7 · Cited by 17
The influence of emotion regulation flexibility on mental health: Evidence from experience sampling
Xiaoqin, W. A. N. G., Yafei, T. A. N., Jie, M. E. N. G., Yuan, L. I. U., Dongtao, W. E. I., Wen-jing, Y., & Qiu, J. (2022) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2023.00192 · Cited by 16
EEG cross-frequency correlations as a marker of predisposition to affective disorders
Knyazev, G. G., Savostyanov, A. N., Bocharov, A. V., & Aftanas, L. I. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02942 · Cited by 17
Cognitive behavioral based group psychotherapy focusing on repetitive negative thinking: Decreased uncontrollability of rumination is related to brain perfusion increases in the left dorsolateral prefrontal cortex
Baeken, C., Wu, G., Rogiers, R., Remue, J., Lemmens, G. M. D., & Raedt, R. D. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.011 · Cited by 18
Self-Referential Dysfunction and Default-Mode Hyperactivation in Psychophysiological Insomnia Patients
Marques, D. R., Gomes, A. A., Clemente, V., dos Santos, J. M., Duarte, I. C., Caetano, G., & Castelo-Branco, M. S. (2017) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000194 · Cited by 16
“Furthermore, they exhibited more neural activity in the amygdala, rostral anterior cingulate/MPFC, dorsolateral prefrontal cortex, PCC, and parahippocampus when contrasting induced rumination against abstract distraction conditions [32].”
Background
Differences in the modulation of functional connectivity by self-talk tasks between people with low and high life satisfaction
Kyeong, S.-H., Kim, J., Kim, J., Kim, E. J., Kim, H. E., & Kim, J.-J. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116929 · Cited by 18
A Computational Network Control Theory Analysis of Depression Symptoms
Kenett, Y. N., Beaty, R. E., & Medaglia, J. D. (2018) · Personality Neuroscience · doi:10.1017/pen.2018.15 · Cited by 15
Effects of attention training technique on brain function in high- and low-cognitive-attentional syndrome individuals: Regional dynamics before, during, and after a single session of ATT
Kowalski, J., Wierzba, M., Wypych, M., Marchewka, A., & Dragan, M. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103693 · Cited by 15
Electrophysiological and behavioral effects of unilateral and bilateral rTMS; A randomized clinical trial on rumination and depression
Kazemi, R., Rostami, R., Nasiri, Z., Hadipour, A. L., Kiaee, N., Coetzee, J. P., Philips, A., Brown, R. E., Seenivasan, S., & Adamson, M. M. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.098 · Cited by 14
Relationship between World Assumptions and Post-Traumatic Growth among Polish Cancer Patients: Moderating Effect of Rumination
Szczęśniak, M., Madej, D., & Bielecka, G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912444 · Cited by 14
“Rumination is associated with deficits in cognitive control [60], attentional inflexibility [52], various undesirable personality traits [56], and the worsening of negative moods [61].”
Background
Neural signal variability relates to maladaptive rumination in depression
Philippi, C. L., Leutzinger, K., Pessin, S., Cassani, A., Mikel, O., Walsh, E. C., Hoks, R. M., Birn, R. M., & Abercrombie, H. C. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.070 · Cited by 14
Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems
Vijayakumar, N., Whittle, S., & Silk, T. J. (2023) · Psychological Medicine · doi:10.1017/s0033291723001472 · Cited by 15
“…connectivity have noted reductions during resting-state with increasing pubertal stage (conceptualized as the observable physical changes driven by hormones), such as decreased hippocampal-dorsal ACC connectivity in females (van Duijvenvoorde, Westhoff, de Vos, Wierenga, & Crone, 2019).”
Converging effects of cocaine addiction and sex on neural responses to monetary rewards
Konova, A. B., Moeller, S. J., Parvaz, M. A., Froböse, M. I., Alia‐Klein, N., & Goldstein, R. Z. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.01.001 · Cited by 14
“The finding that female cocaine users exhibited the lowest activations in these regions is also notable in light of the role of the default mode in rumination (Berman et al., 2011; Cooney et al., 2010) and depression (Sheline et al.”
Background
Persistent Intrinsic Functional Network Connectivity Alterations in Middle-Aged and Older Women With Remitted Depression
Vega, J. N., Taylor, W. D., Gandelman, J. A., Boyd, B. D., NEWHOUSE, P. A., Shokouhi, S., & Albert, K. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00062 · Cited by 16
“Compared with neverdepressed adults, in adult MDD, DMN activity is higher when assessing external stimuli (17) and during maladaptive ruminative self-focus (18).”
Background
Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study
Piani, M. C., Maggioni, E., Delvecchio, G., Ferro, A., Gritti, D., Pozzoli, S. M., Fontana, E., Enrico, P., Cinnante, C. M., Triulzi, F. M., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.683912 · Cited by 14
“Indeed, the region is considered to be a component of the DMN (96, 127, 128) and deficits in this region have been associated with clinical symptoms often observed in MDD, including rumination, abnormal retrieval of autobiographical memory (109), and generation of contextual associates (129).”
Background
Behavioral and neural mechanisms underlying cognitive vulnerability models of depression.
Auerbach, R. P., Webb, C. A., Gardiner, C. K., & Pechtel, P. (2013) · Journal of Psychotherapy Integration · doi:10.1037/a0031417 · Cited by 14
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK BiobankPreprint
Shen, X., Howard, D. M., Adams, M. J., Deary, I. J., Whalley, H. C., & McIntosh, A. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/617969 · Cited by 14
Differential patterns of default mode network activity associated with negative and positive rumination in bipolar disorder
Ghaznavi, S., Chou, T., Dougherty, D. D., & Nierenberg, A. A. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.12.014 · Cited by 13
Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls
Yoon, L., Keenan, K. E., Hipwell, A. E., Forbes, E. E., & Guyer, A. E. (2023) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2023.101320 · Cited by 13
“Although the majority of studies included in this meta-analysis used rumination induction tasks (Denson et al., 2009; Kross et al., 2009; Cooney et al., 2010; Fabiansson et al., 2012; Kowalski et al., 2019) or self-referential tasks (Marques et al., 2018; Nejad et al., 2019) that elicited neural…”
Background
Unraveling how the adolescent brain deals with criticism using dynamic causal modeling
Chen, Q., Bonduelle, S. L. B., Wu, G., Vanderhasselt, M., Raedt, R. D., & Baeken, C. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120510 · Cited by 15
“Experimental findings have shown that rumination is associated with a decrease in inhibition of DMN activity (Bartova et al., 2015), particularly the active state of the preCUN (Cooney et al., 2010; Zhou et al., 2020).”
Mental Effort: Brain and Autonomic Correlates in Health and Disease
Radulescu, E., Nagai, Y., & Critchley, H. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1236-0_16 · Cited by 13
The processing of angry faces in schizophrenia patients with a history of suicide: An fMRI study examining brain activity and connectivity
Athanassiou, M., Dumais, A., Iammatteo, V., Benedictis, L. D., Dubreucq, J.-L., & Potvin, S. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110253 · Cited by 14
Depressive symptoms following traumatic brain injury are associated with resting-state functional connectivity
Luo, L., Langley, C., Moreno-López, L., Kendrick, K. M., Menon, D. K., Stamatakis, E. A., & Sahakian, B. J. (2021) · Psychological Medicine · doi:10.1017/s0033291721004724 · Cited by 12
Psychometric Properties of the Chinese Version of the Brief State Rumination Inventory
Wang, C., Song, X., Lee, T. M. C., & Zhang, R. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.824744 · Cited by 13
“In previous paradigms of exploring the neural mechanism of rumination, sentence-induced rumination has mostly been used, and the main indicators for measuring whether rumination is successfully induced are the degree of self-focus and the degree of sadness (24, 55).”
Background
Association Between Antidepressant Efficacy and Interactions of Three Core Depression-Related Brain Networks in Major Depressive Disorder
Wang, Q., Tian, S., Zhao, P., Cao, Q., Lü, Q., & Yao, Z. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.862507 · Cited by 13
“This is manifested most prominently in depressed patients for whom rumination leads to impaired cognitive resource allocation (32, 33).”
Background
Interactions between Personality, Depression, Anxiety and Cognition to Understand Early Stage of Alzheimer’s Disease
Zufferey, V., von Gunten, A., & Kherif, F. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200211110545 · Cited by 13
The Predictive Role of Cognitive Emotion Regulation of Adolescents with Chronic Disease and Their Parents in Adolescents’ Quality of Life: A Pilot Study
Cserép, M., Szabó, B., Tóth‐Heyn, P., Szabo, A. J., & Szumska, I. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192316077 · Cited by 18
Individual- and Connectivity-Based Real-Time fMRI Neurofeedback to Modulate Emotion-Related Brain Responses in Patients with Depression: A Pilot Study
Maywald, M., Paolini, M., Rauchmann, B., Christian, G., Heppe, J. L., Wolf, A., Lerchenberger, L., Tominschek, I., Stoecklein, S., Reidler, P., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12121714 · Cited by 12
“The parahippocampal gyrus is known to be involved in memory-function, rumination and depression [60,112,113].”
Background
The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder–Fine-Grained Meta-Analyses
Romeo, Z., Biondi, M., Oltedal, L., & Spironelli, C. (2024) · Depression and Anxiety · doi:10.1155/2024/6673522 · Cited by 12
“Interestingly, Cooney et al. found that the parahippocampal activity was higher in depressed patients than healthy individuals during rumination [164], whereas Zamoscik et al. found that greater connectivity between the parahippocampus and default mode network in MDD patients was related to a…”
Diagnosis of late-life depression using structural equation modeling and dynamic effective connectivity during resting fMRI
Cosío‐Guirado, R., Soriano‐Mas, C., del Cerro, I., Urretavizcaya, M., Menchón, J. M., Soria, V., Cañete‐Massé, C., Peró, M., & Guàrdia‐Olmos, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.010 · Cited by 12
Rewiring of neuronal networks during synaptic silencing
Dahlmanns, J. K., von Einem, V., Breininger, K., Dahlmanns, M., Maier, A., Kornhuber, J., & Groemer, T. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-11729-5 · Cited by 12
Regulating Rumination by Anger: Evidence for the Mutual Promotion and Counteraction (MPMC) Theory of Emotionality
Zhan, J., Tang, F., He, M. L., Fan, J., Xiao, J., Liu, C., & Luo, J. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01871 · Cited by 13
“…of negative mood states (e.g., sadness, tension, and self-focus) and has been shown to increase one’s vulnerability to developing or exacerbating depression (Nolen-Hoeksema, 1991; Cooney et al., 2010; Roberts et al., 2013). the recursive relationships among joy, thinking and anger is not suitable.”
Background
Psychiatric Comorbidity and Emotional Dysregulation in Chronic Tension-Type Headache: A Case-Control Study
Romero-Godoy, R., Romero-Godoy, S. R., Romero‐Acebal, M., & Gutiérrez‐Bedmar, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175090 · Cited by 11
A mediated moderation model of negative life events, self-esteem, rumination and parental divorce on depression among Chinese juvenile delinquents
Zhao, S., Ren, R., & Chen, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-28626-9 · Cited by 14
Negative association between non‐suicidal self‐injury in adolescents and default mode network activation during the distraction blocks of a rumination task
Schreiner, M. W., Roberts, H., Dillahunt, A. K., Farstead, B. W., Feldman, D. A., Thomas, L. R., Jacobs, R. H., Bessette, K. L., Welsh, R. C., Watkins, E. R., et al. (2023) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12960 · Cited by 11
Altered cortical myelin in the salience and default mode networks in major depressive disorder patients: A surface-based analysis
Zhang, S., She, S., Qiu, Y., Li, Z., Mao, D., Zheng, W., Wu, H., & Huang, R. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.068 · Cited by 11
Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals
Smet, S. D., Int-Veen, I., Vanhollebeke, G., Pulopulos, M. M., Barth, B., Pasche, S., Baeken, C., Nuerk, H., Plewnia, C., Nieratschker, V., et al. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.03.016 · Cited by 11

Authors: Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H.
Affiliations: Stanford University (US)
University of Miami (US)
Concordia University (CA)
Corresponding author: Cooney, Rebecca E.
ORCID: Cooney, Rebecca E.
Joormann, Jutta
Dennis, Emily L.
Gotlib, Ian H.
Venue: Cognitive, Affective, & Behavioral Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-12
Volume: 10
Issue: 4
Pages: 470-478
ISSN: 1530-7026 (ISSN-L)
1531-135X
DOI: 10.3758/cabn.10.4.470
PMC: PMC4476645
OpenAlex: W2083730492
Semantic Scholar: 7cfcec0eec853fe3db0b31fdaa15113a4a7fe039
Cited by: 493
References: 44
Citations by year: 2026: 25 · 2025: 35 · 2024: 36 · 2023: 33 · 2022: 41 · 2021: 45 · 2020: 41 · 2019: 34 · 2018: 29 · 2017: 28 · 2016: 23 · 2015: 28 · 2014: 27 · 2013: 25 · 2012: 30
FWCI: 27.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cognitive Affective & Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH59259, R01MH059259)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: rumination, major depressive disorder, neural correlates, orbitofrontal cortex, subgenual anterior cingulate cortex, dorsolateral prefrontal cortex, amygdala, limbic system, medial prefrontal cortex, posterior cingulate cortex, parahippocampal cortex
MeSH terms: Adult, Analysis of Variance, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Reaction Time, Thinking, Young Adult

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Neural correlates of rumination in depression

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