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Neural correlates of rumination in depression
Open accessAbstract
Rumination, or recursive self-focused thinking, has important implications for understanding the development and maintenance of depressive episodes. Rumination is associated with the worsening of negative mood states, greater affective responding to negative material, and increased access to negative memories. The present study was designed to use fMRI to examine neural aspects of rumination in depressed and healthy control individuals. We used a rumination induction task to assess differences in patterns of neural activation during ruminative self-focus as compared with a concrete distraction condition and with a novel abstract distraction condition in 14 participants who were diagnosed with major depressive disorder and 14 healthy control participants. Depressed participants exhibited increased activation in the orbitofrontal cortex, subgenual anterior cingulate, and dorsolateral prefrontal cortex as compared with healthy controls during rumination versus concrete distraction. Neural activity during rumination versus abstract distraction was greater for depressed than for control participants in the amygdala, rostral anterior cingulate/medial prefrontal cortex, dorsolateral prefrontal cortex, posterior cingulate, and parahippocampus. These findings indicate that ruminative self-focus is associated with enhanced recruitment of limbic and medial and dorsolateral prefrontal regions in depression. Supplemental materials for this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental.
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“One of the most frequently reported neuroimaging findings in MDD is abnormally increased connectivity and heightened activation of the amygdala 99-101 .”
From Major depressive disorder (2016) · cites this paper as [100]
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“Similarly, task-based studies examining trait levels of worry or depressive rumination (e.g., Paulus and Stein, 2010; Hamilton et al., 2011) or instructions to worry or ruminate (e.g., Cooney et al., 2010; Paulus and Stein, 2010; Ottaviani et al., 2016) demonstrate neural activations in nodes of the DN.”
From Distinct functional connectivities predict clinical response with emotion regulation therapy (2017) · cites this paper as Cooney et al., 2010
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“Moreover, decreased frontoparietal connectivity has been found both at rest and in response to negative stimuli, but not in response to positive stimuli, suggesting that this network may contribute to inappropriate cognitive appraisals of negative events more specifically 100,105 .”
From Major depressive disorder (2016) · cites this paper as [100]
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Metadata
- Authors
- Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- University of Miami (US)
- Concordia University (CA)
- Corresponding author
- Cooney, Rebecca E.
- Venue
- Cognitive, Affective, & Behavioral Neuroscience
- Published
- 2010-12
- Volume
- 10
- Issue
- 4
- Pages
- 470-478
- ISSN
- 1530-7026 (ISSN-L)
- 1531-135X
- PMC
- PMC4476645
- OpenAlex
- W2083730492
- Semantic Scholar
- 7cfcec0eec853fe3db0b31fdaa15113a4a7fe039
- Cited by
- 493
- References
- 44
- Citations by year
- 2026: 25 · 2025: 35 · 2024: 36 · 2023: 33 · 2022: 41 · 2021: 45 · 2020: 41 · 2019: 34 · 2018: 29 · 2017: 28 · 2016: 23 · 2015: 28 · 2014: 27 · 2013: 25 · 2012: 30
- FWCI
- 27.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cognitive Affective & Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH59259, R01MH059259)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- rumination, major depressive disorder, neural correlates, orbitofrontal cortex, subgenual anterior cingulate cortex, dorsolateral prefrontal cortex, amygdala, limbic system, medial prefrontal cortex, posterior cingulate cortex, parahippocampal cortex
- MeSH terms
- Adult, Analysis of Variance, Brain, Brain Mapping, Major Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Reaction Time, Thinking, Young Adult
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