Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis
Open accessAbstract
Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and controls and to test the protective effects of pigment epithelium-derived factor (PEDF), a known neurotrophic and antiangiogenic substance, against neurotrophic keratouveitis. Histopathological alterations were studied by means of morphometry, light and electron microscopy. Unexpectedly, morphometric data showed that the RPE alterations noted in AMD may also develop in normal aging, 10-15 years later than appearing in AMD patients. Reduced tear secretion, corneal ulceration and leukocytic infiltration were found in capsaicin (CAP)-treated rats, but this effect was significantly attenuated by PEDF. These findings suggest that PEDF accelerated the recovery of tear secretion and also prevented neurotrophic keratouveitis and vitreoretinal inflammation. PEDF may have a clinical application in inflammatory and neovascular diseases of the eye.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AMD donor RPE shows signs of disintegrated mitochondria relative to age-matched unaffected donors.
“along with signs of disintegrated mitochondria, relative to age-matched unaffected donors (Feher et al., 2006; Bianchi et al., 2013)”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Bianchi et al., 2013
Peroxisome numbers are elevated in AMD donor RPE relative to age-matched unaffected donors.
“peroxisome numbers were shown to be elevated in AMD donor RPE”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Bianchi et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mitochondrial control of cell death
Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103 · see citing works
Prevalence of Age-Related Macular Degeneration in the United States
The Eye Diseases Prevalence Research Group* (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.564 · Cited by 2,742 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164 · see citing works
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116 · see citing works
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051 · see citing works
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956 · see citing works
Bird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926 · see citing works
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works
Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
Dawson, D. W., Volpert, O. V., Gillis, P., Crawford, S. E., Xu, H.-J., Benedict, W., & Bouck, N. (1999) · Science · doi:10.1126/science.285.5425.245 · Cited by 1,500 · see citing works
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works
A role for local inflammation in the formation of drusen in the aging eye
Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087 · see citing works
Keller, H., Dreyer, C., Medin, J. A., Mahfoudi, A., Ozato, K., & Wahli, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2160 · Cited by 948 · see citing works
The epidemiology of age-related macular degeneration
Klein, R., Peto, T., Bird, A., & Vannewkirk, M. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.069 · Cited by 932 · see citing works
Age-Specific Prevalence and Causes of Blindness and Visual Impairment in an Older Population
Klaver, C. C. W. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.5.653 · Cited by 889 · see citing works
Metabolism of highly unsaturated n-3 and n-6 fatty acids
Sprecher, H. W. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00077-9 · Cited by 869 · see citing works
The mitochondrial‐lysosomal axis theory of aging
Brunk, U. T., & Terman, A. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02869.x · Cited by 729 · see citing works
Vascular endothelial growth factor: Direct neuroprotective effect in <i>in vitro</i> ischemia
Jin, K. L., Mao, X. O., & Greenberg, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10242 · Cited by 684 · see citing works
RPE lipofuscin and its role in retinal pathobiology
Sparrow, J. R., & Boulton, M. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.007 · Cited by 644 · see citing works
The role of the lacrimal functional unit in the pathophysiology of dry eye
Stern, M. E., Gao, J., Siemasko, K. F., Beuerman, R. W., & Pflugfelder, S. C. (2003) · Experimental Eye Research · doi:10.1016/j.exer.2003.09.003 · Cited by 573 · see citing works
Oxidative Damage and Age Related Macular Degeneration
Renganathan, K. (2008) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 565 · see citing works
(1999) · PubMed · Cited by 539 · see citing works
The Role of Apoptosis in Age-Related Macular Degeneration
Dunaief, J. L. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.11.1435 · Cited by 527 · see citing works
Age-Related Macular Degeneration
Fine, S. L., Berger, J. W., Maguire, M. G., & Ho, A. C. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420707 · Cited by 418 · see citing works
Korn, E. D. (1978) · Springer eBooks · doi:10.1007/978-1-4613-4036-2 · Cited by 412 · see citing works
Gosker, H. R., Wouters, E. F. �., Vusse, G. J., & Schols, A. M. W. J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1033 · Cited by 406 · see citing works
Neuronal degeneration and mitochondrial dysfunction
Schon, E. A., & Manfredi, G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17741 · Cited by 393 · see citing works
Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration
Feher, J., Kovacs, I., Artico, M., Cavallotti, C., Papale, A., & Balacco Gabrieli, C. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.012 · Cited by 388 · see citing works
Self-citationLipofuscin of the retinal pigment epithelium: A review
Kennedy, C. J., Rakoczy, P. E., & Constable, I. J. (1995) · Eye · doi:10.1038/eye.1995.192 · Cited by 366 · see citing works
Forty years in capsaicin research for sensory pharmacology and physiology
Szolcsányi, J. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.07.005 · Cited by 364 · see citing works
Neuronal degeneration and mitochondrial dysfunction
Schon, E. A., & Manfredi, G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317741 · Cited by 326 · see citing works
Age‐related Macular Degeneration (AMD)
(2008) · Springer eBooks · doi:10.1007/978-3-540-38918-7_5059 · Cited by 322 · see citing works
A2E, a byproduct of the visual cycle
Sparrow, J. R., Fishkin, N., Zhou, J., Cai, B., Jang, Y. P., Krane, S., Itagaki, Y., & Nakanishi, K. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00475-9 · Cited by 318 · see citing works
Age-related Macular Degeneration
Suter, M., Remé, C., Grimm, C., Wenzel, A., Jäättelä, M., Esser, P., Kociok, N., Leist, M., & Richter, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007049200 · Cited by 315 · see citing works
Regulation of mammalian pyruvate dehydrogenase
Denton, R. M., Randle, P. J., Bridges, B. J., Cooper, R. H., Kerbey, A. L., Pask, H. T., Severson, D. L., Stansbie, D., & Whitehouse, S. (1975) · Molecular and Cellular Biochemistry · doi:10.1007/bf01731731 · Cited by 304 · see citing works
Unbalanced expression of VEGF and PEDF in ischemia‐induced retinal neovascularization
Gao, G., Li, Y., Zhang, D., Gee, S., Crosson, C. E., & Ma, J.-X. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02110-x · Cited by 297 · see citing works
Zachary, I. C. (2005) · Neurosignals · doi:10.1159/000088637 · Cited by 267 · see citing works
Loss of the Antiangiogenic Pigment Epithelium-Derived Factor in Patients With Angiogenic Eye Disease
Spranger, J., Osterhoff, M. A., Reimann, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2641 · Cited by 243 · see citing works
PEDF: anti-angiogenic guardian of ocular function
Bouck, N. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02362-6 · Cited by 235 · see citing works
Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine
Ben-Shachar, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01263.x · Cited by 232 · see citing works
Tombran‐Tink, J., Shivaram, S., Chader, G. J., Johnson, L., & Bok, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04992.1995 · Cited by 218 · see citing works
Un nouveau schéma pour mieux comprendre les maladies de la surface oculaire
Baudouin, C. (2007) · Journal Français d Ophtalmologie · doi:10.1016/s0181-5512(07)89584-2 · Cited by 200 · see citing works
Peripheral TRPV1 Receptors As Targets for Drug Development: New Molecules and Mechanisms
SZALLASI, A., & Gunthorpe, M. J. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783330754 · Cited by 199 · see citing works
How Mitochondrial Damage Affects Cell Function
James, A. M., & Murphy, M. P. (2002) · Journal of Biomedical Science · doi:10.1159/000064721 · Cited by 182 · see citing works
Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization.
Murata, T., He, S., Hangai, M., Ishibashi, T., Xi, X. P., Kim, S., Hsueh, W. A., Ryan, S. J., Law, R. E., & Hinton, D. R. (2000) · PubMed · Cited by 179 · see citing works
Rakoczy, P. E., Zhang, D., Robertson, T., Barnett, N. L., Papadimitriou, J., Constable, I. J., & Lai, C.-M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64427-6 · Cited by 173 · see citing works
Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina
Andrews, R. M., Griffiths, P. G., Johnson, M. A., & Turnbull, D. M. (1999) · British Journal of Ophthalmology · doi:10.1136/bjo.83.2.231 · Cited by 167 · see citing works
Paradies, G., Ruggiero, F. M., Petrosillo, G., & Quagliariello, E. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00264-0 · Cited by 163 · see citing works
Marmorstein, A. D., Marmorstein, L. Y., Sakaguchi, H., & Hollyfield, J. G. (2002) · PubMed · Cited by 154 · see citing works
Nucci, C., Gasperi, V., Tartaglione, R., Cerulli, A., Terrinoni, A., Bari, M., Simone, C. D., Finazzi‐Agrò, A., Morrone, L. A., Corasaniti, M. T., et al. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1355 · Cited by 137 · see citing works
β-Oxidation – strategies for the metabolism of a wide variety of acyl-CoA esters
Hiltunen, J. K., & Qin, Y. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00013-5 · Cited by 136 · see citing works
Furuno, T., Kanno, T., Arita, K., Asami, M., Utsumi, T., Doi, Y., Inoue, M., & Utsumi, K. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00745-6 · Cited by 131 · see citing works
Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin.
Shamsi, F. A., & Boulton, M. (2001) · PubMed · Cited by 130 · see citing works
Transport of fatty acids and metabolites across the peroxisomal membrane
Hettema, E. H., & Tabak, H. F. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00045-7 · Cited by 126 · see citing works
Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures
Khaibullina, A. A., Rosenstein, J. M., & Krum, J. M. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.022 · Cited by 114 · see citing works
Kijlstra, A., Heij, E. C. L., & Hendrikse, F. (2005) · Ocular Immunology and Inflammation · doi:10.1080/09273940590909185 · Cited by 106 · see citing works
Mitochondria and aging: A role for the permeability transition?
Crompton, M. (2004) · Aging Cell · doi:10.1046/j.1474-9728.2003.00073.x · Cited by 101 · see citing works
Sundelin, S., Wihlmark, U., NILSSON, S. E. G., & Brunk, U. T. (1998) · Current Eye Research · doi:10.1080/02713689808951268 · Cited by 101 · see citing works
Effects of capsaicin on corneal wound healing.
Gallar, J., Pozo, M. A., Rebollo, I., & Belmonte, C. (1990) · PubMed · Cited by 96 · see citing works
Aloe, L., Tirassa, P., & Lambìase, A. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.01.010 · Cited by 95 · see citing works
Becerra, S. P., Palmer, I. W., Kumar, A., Steele, F. R., Shiloach, J., Notario, V., & Chader, G. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49439-8 · Cited by 92 · see citing works
Age-related structural and functional changes of brain mitochondria
Toescu, E. C., Myronova, N., & Verkhratsky, A. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0167 · Cited by 83 · see citing works
May, A. (1998) · Brain · doi:10.1093/brain/121.7.1231 · Cited by 82 · see citing works
Lipofuscin and Macular Degeneration
Wolf, G. (2003) · Nutrition Reviews · doi:10.1301/nr.2003.oct.342-346 · Cited by 81 · see citing works
Mitochondrial Function In Ischaemia And Reperfusion Of The Ageing Heart
Pepe, S. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03326.x · Cited by 80 · see citing works
Rottenberg, H., & Wu, S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7605 · Cited by 79 · see citing works
Ocular neovascularisation and excessive vascular permeability
Campochiaro, P. A. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.9.1395 · Cited by 77 · see citing works
Expression of neuropeptides and their receptors in the developing retina of mammals.
Bagnoli, P., Monte, M. D., & Casini, G. (2003) · PubMed · doi:10.14670/hh-18.1219 · Cited by 75 · see citing works
Ion channels and membrane rafts in apoptosis
Szab�, I., Adams, C., & Gulbins, E. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1259-4 · Cited by 71 · see citing works
Mitochondrial Membrane Potential in Aging Cells
Sugrue, M. M., & Tatton, W. G. (2001) · Neurosignals · doi:10.1159/000046886 · Cited by 65 · see citing works
Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization
Kuksa, V., Imanishi, Y., Batten, M., Palczewski, K., & Moise, A. R. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00482-6 · Cited by 64 · see citing works
Proteomic Approaches to Understanding Age-Related Macular Degeneration
Hollyfield, J. G., Salomon, R. G., & Crabb, J. W. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0067-4_11 · Cited by 63 · see citing works
Capsaicin‐induced neuronal degeneration in the brain and retina of preweanling rats
Ritter, S., & Dinh, T. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902960310 · Cited by 62 · see citing works
Jin, G.-F., Hurst, J. S., & Godley, B. F. (2001) · Current Eye Research · doi:10.1076/ceyr.23.1.11.5423 · Cited by 58 · see citing works
Kovács, I., Ludány, A., Kőszegi, T., et al. (2005) · Neuropeptides · doi:10.1016/j.npep.2005.04.003 · Cited by 56 · see citing works
Peptidergic nerves in the eye, their source and potential pathophysiological relevance
Troger, J., Kieselbach, G. F., Teuchner, B., Kralinger, M. T., Nguyen, Q. A., Haas, G., Yayan, J., Göttinger, W., & Schmid, E. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.06.002 · Cited by 56 · see citing works
Colocalization of substance P and GABA in retinal ganglion cells: A computer-assisted visualization
Caruso, D. M., Owczarzak, M. T., & Pourcho, R. G. (1990) · Visual Neuroscience · doi:10.1017/s095252380000047x · Cited by 56 · see citing works
Neurogenic Inflammation: A First Line of Defense for the Ocular Surface
Beuerman, R. W., & Stern, M. E. (2005) · The Ocular Surface · doi:10.1016/s1542-0124(12)70256-2 · Cited by 54 · see citing works
Fox, D. A., Poblenz, A. T., He, L., Harris, J. B., & Medrano, C. J. (2003) · European Journal of Ophthalmology · doi:10.1177/112067210301303s08 · Cited by 52 · see citing works
Mitochondrial Fatty Acid β-Oxidation in the Retinal Pigment Epithelium
Tyni, T. A., Johnson, M., Eaton, S. D., Pourfarzam, M., Andrews, R. M., & Turnbull, D. M. (2002) · Pediatric Research · doi:10.1203/00006450-200210000-00021 · Cited by 52 · see citing works
Capsaicin-induced neuroparalytic keratitis-like corneal changes in the mouse
Fujita, S., Shimizu, T., Izumi, K., et al. (1984) · Experimental Eye Research · doi:10.1016/0014-4835(84)90100-3 · Cited by 50 · see citing works
Zammit, V. A., Corstorphine, C. G., Kolodziej, M. P., & Fraser, F. W. (1998) · Lipids · doi:10.1007/s11745-998-0217-7 · Cited by 49 · see citing works
Electron Microscopic Methods in Membrane Biology
Zingsheim, H. P., & Plattner, H. (1976) · Springer eBooks · doi:10.1007/978-1-4757-5820-7_1 · Cited by 48 · see citing works
Brecha, N. C., Sternini, C., Anderson, K. E., et al. (1989) · Visual Neuroscience · doi:10.1017/s095252380000986x · Cited by 48 · see citing works
Mitotropic Compounds for the Treatment of Age-Related Macular Degeneration
Fehér, J., Papale, A., Mannino, G., Gualdi, L., & Gabrieli, C. B. (2003) · Ophthalmologica · doi:10.1159/000071351 · Cited by 41 · see citing works
Self-citationPeripheral benzodiazepine receptor: structure and function in health and disease.
Papadopoulos, V. D. (2003) · PubMed · Cited by 39 · see citing works
Shaban, H., Borrás, C., Viña, J., & Richter, C. (2002) · Experimental Eye Research · doi:10.1006/exer.2001.1192 · Cited by 39 · see citing works
Gabbita, S. P., Subramaniam, R., Allouch, F., Carney, J. M., & Butterfield, D. A. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00040-6 · Cited by 38 · see citing works
Sprouting of corneal sensory fibers in rats treated at birth with capsaicin.
Ogilvy, C. S., Silverberg, K. R., & Borges, L. F. (1991) · PubMed · Cited by 37 · see citing works
Reversible accumulation of lipofuscin-like inclusions in the retinal pigment epithelium.
Katz, M. L., Rice, L. M., & Gao, C. (1999) · PubMed · Cited by 33 · see citing works
Hansson, M. E. A., Ellis, E. C. S., Hunt, M. C., Schmitz, G., & Babiker, A. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00398-1 · Cited by 31 · see citing works
Interaction of cartinine with mitochondrial cardiolipin
Battelli, D., Bellei, M., Arrigoni‐Martelli, E., Muscatello, U., & Bobyleva, V. (1992) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(92)90158-q · Cited by 30 · see citing works
Microperoxisomes in retinal pigment epithelium.
Robison, W. G., & Kuwabara, T. (1975) · PubMed · Cited by 29 · see citing works
Mitochondrial Fatty Acid beta-Oxidation in the Retinal Pigment Epithelium
TYNI, T. (2002) · Pediatric Research · doi:10.1203/01.pdr.0000030874.20888.2d · Cited by 28 · see citing works
Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors
Lázár, J., Szabó, T. G., Marincsák, R., Kovács, L., Blumberg, P. M., & Bı́ró, T. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.11.023 · Cited by 25 · see citing works
Interactions of lipids with peripheral-type benzodiazepine receptors
Beaumont, K. C., Skowroński, R., Vaughn, D. A., & Fanestil, D. D. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90502-3 · Cited by 24 · see citing works
Chung, C., Doll, J. A., Stellmach, V., et al. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-69080-3_61 · Cited by 23 · see citing works
Expression of neurotransmitters and neurotrophins in neurogenic inflammation of the rat retina.
Bronzetti, E., Artico, M., Kovács, I., Felici, L., Magliulo, G., Vignone, D., D'Ambrosio, A., Forte, F., Liddo, R. D., & Fehér, J. (2007) · PubMed · doi:10.4081/1149 · Cited by 21 · see citing works
Self-citationvon Rückmann, A., Schmidt, K. G., Fitzke, F. W., Bird, A. C., & Kw, J. (1998) · PubMed · Cited by 19 · see citing works
A cholesterol-binding and transporting protein from rat liver mitochondria
Campbell, A. M., Capuano, A., & Chan, S. H. P. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00607-7 · Cited by 18 · see citing works
Pigment Epithelium–Derived Factor (PEDF) Attenuated Capsaicin-Induced Neurotrophic Keratouveitis
Fehér, J., Kovács, I., Pacella, E., Keresz, S., Spagnardi, N., & Gabrieli, C. B. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1852 · Cited by 11 · see citing works
Self-citationAge-related macular degeneration
El-Amir, A., Sagoo, M. S., & da Cruz, L. (2005) · British Journal of Hospital Medicine · doi:10.12968/hmed.2005.66.12.20206 · Cited by 10 · see citing works
Effects of Neuropeptides on the Sumatriptan-Disturbed Circulation in the Optic Nerve Head of Rabbits
Gaspar, M. N., Ribeiro, C., Cunha-Vaz, J. G., et al. (2004) · Pharmacology · doi:10.1159/000074978 · Cited by 8 · see citing works
Induction of keratouveitis by capsaicin
Waldrep, J. C., & Crosson, C. E. (1988) · Current Eye Research · doi:10.3109/02713688809033221 · Cited by 7 · see citing works
Contribution of Neurogenic Inflammation to Irritable Eye Syndrome
Fehér, J. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0717-8_148 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works
Brown, E. E., DeWeerd, A. J., Ildefonso, C. J., Lewin, A. S., & Ash, J. D. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101201 · Cited by 259 · see citing works
Daniele, L. L., Caughey, J., Volland, S., Sharp, R. C., Dhingra, A., Williams, D. S., Philp, N. J., & Boesze-Battaglia, K. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00185.2019 · Cited by 16 · see citing works
- Authors
- BIANCHI, E., SCARINCI, F., RIPANDELLI, G., FEHER, J., PACELLA, E., MAGLIULO, G., GABRIELI, C. B., PLATEROTI, R., PLATEROTI, P., MIGNINI, F., & ARTICO, M.
- Affiliations
- Sapienza University of Rome (IT)
- Fondazione G.B. Bietti (IT)
- Università di Camerino (IT)
- ORCID
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2012-10-26
- Volume
- 31
- Issue
- 1
- Pages
- 232-242
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- OpenAlex
- W2127701223
- Cited by
- 40
- References
- 105
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Keywords
- retinal pigment epithelium, age-related macular degeneration, pigment epithelium-derived factor, mitochondrial changes, normal aging, tear secretion, corneal ulcer, leukocyte infiltration, vitreoretinal inflammation, capsaicin, anti-angiogenic therapy
- MeSH terms
- Pigment Epithelium-Derived Factor, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Animals, Capsaicin, Child, Child, Preschool, Eye Proteins, Female, Humans, Macular Degeneration, Male, Microscopy, Electron, Middle Aged, Mitochondria, Nerve Growth Factors, Pigment Epithelium of Eye, Tears, Uveitis, Serpins, Rats, Sprague-Dawley, Rats, Retinal Pigment Epithelium, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review