Cited by 40Retinal Diseases and TreatmentsRetinal Development and DisordersOcular Surface and Contact Lens

Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis

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BIANCHI, ENRICA, SCARINCI, FABIO, RIPANDELLI, GUIDO, FEHER, JANOS, PACELLA, ELENA, MAGLIULO, GIUSEPPE, GABRIELI, CORRADO BALACCO, PLATEROTI, ROCCO +3 more·2013·International Journal of Molecular Medicine

Abstract

Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and controls and to test the protective effects of pigment epithelium-derived factor (PEDF), a known neurotrophic and antiangiogenic substance, against neurotrophic keratouveitis. Histopathological alterations were studied by means of morphometry, light and electron microscopy. Unexpectedly, morphometric data showed that the RPE alterations noted in AMD may also develop in normal aging, 10-15 years later than appearing in AMD patients. Reduced tear secretion, corneal ulceration and leukocytic infiltration were found in capsaicin (CAP)-treated rats, but this effect was significantly attenuated by PEDF. These findings suggest that PEDF accelerated the recovery of tear secretion and also prevented neurotrophic keratouveitis and vitreoretinal inflammation. PEDF may have a clinical application in inflammatory and neovascular diseases of the eye.

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  • AMD donor RPE shows signs of disintegrated mitochondria relative to age-matched unaffected donors.

    “along with signs of disintegrated mitochondria, relative to age-matched unaffected donors (Feher et al., 2006; Bianchi et al., 2013)”

    From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Bianchi et al., 2013

  • Peroxisome numbers are elevated in AMD donor RPE relative to age-matched unaffected donors.

    “peroxisome numbers were shown to be elevated in AMD donor RPE”

    From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Bianchi et al., 2013

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Authors
BIANCHI, E., SCARINCI, F., RIPANDELLI, G., FEHER, J., PACELLA, E., MAGLIULO, G., GABRIELI, C. B., PLATEROTI, R., PLATEROTI, P., MIGNINI, F., & ARTICO, M.
Affiliations
  • Sapienza University of Rome (IT)
  • Fondazione G.B. Bietti (IT)
  • Università di Camerino (IT)
Venue
International Journal of Molecular Medicine
Published
2012-10-26
Volume
31
Issue
1
Pages
232-242
ISSN
  • 1107-3756 (ISSN-L)
  • 1791-244X
OpenAlex
W2127701223
Cited by
40
References
105
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 1
FWCI
1.20
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
Keywords
retinal pigment epithelium, age-related macular degeneration, pigment epithelium-derived factor, mitochondrial changes, normal aging, tear secretion, corneal ulcer, leukocyte infiltration, vitreoretinal inflammation, capsaicin, anti-angiogenic therapy
MeSH terms
Pigment Epithelium-Derived Factor, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Animals, Capsaicin, Child, Child, Preschool, Eye Proteins, Female, Humans, Macular Degeneration, Male, Microscopy, Electron, Middle Aged, Mitochondria, Nerve Growth Factors, Pigment Epithelium of Eye, Tears, Uveitis, Serpins, Rats, Sprague-Dawley, Rats, Retinal Pigment Epithelium, Young Adult

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