Mesenchymal stem cells promote tumor engraftment and metastatic colonization in rat osteosarcoma model
Open accessAbstract
Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in rat osteosarcoma model. Results from subcutaneous co-implantation of rat osteosarcoma COS1NR cells, established in our laboratory, with rat MSCs isolated from femur bone marrow showed that the incidence of tumor formation and tumor growth rate was higher until 5 weeks compared to COS1NR cell inoculation alone. However, no difference was observed in tumor growth afterwards and in the number of metastatic nodules at 9 weeks (0.75 vs. 1.2). Intravenous MSC injection at weeks 3 and 5 after subcutaneous inoculation of COS1NR cells significantly increased the number of lung nodules in the group with MSC injection compared to the group without MSC injection (17.33 vs. 2.0), while no difference was observed in subcutaneous tumor growth between those groups. Pathway analysis from gene expression profile identified that genes involved in focal adhesion, cytokine-cytokine receptor and extracellular matrix-receptor pathways such as CAMs (ICAM and VCAM)-integrins were highly expressed in MSCs, possibly participating in the tumor progression of osteosarcoma. These results suggest that MSCs could provide a source of microenvironments for osteosarcoma cells, and might enhance the ability of settlement and colonization which lead to early onset of growth and metastasis, possibly through their activated pathways interaction.
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Data from animal models indicates that mesenchymal stromal cells could accelerate pulmonary metastases.
“Data from animal models indicates that mesenchymal stromal cells could accelerate pulmonary metastases, promote proliferation of sarcoma cells and increase chemoresistance.”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
Data from animal models indicates that mesenchymal stromal cells could promote proliferation of sarcoma cells.
“Data from animal models indicates that mesenchymal stromal cells could accelerate pulmonary metastases, promote proliferation of sarcoma cells and increase chemoresistance.”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
The co-implantation of rat bone marrow mesenchymal stromal cells and COS1NR osteosarcoma cells resulted in the acceleration of non-metastatic cancer settlement and proliferation.
“The co-implantation of rat BMMSCs and COS1NR osteosarcoma cells resulted in the acceleration of non-metastatic cancer settlement and proliferation in a study by Tsukamoto et al.”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
Intravenous bone marrow mesenchymal stromal cell injection led to stabilization of the initial tumour size, without altering its histological appearance, and significant enhancement of metastatic lung nodules (17.33 ± 8.39 vs. 2.0 ± 2.0, p = 0.03).
“On the other hand, intravenous BMMSC injection led to stabilization of the initial tumour size, without altering its histological appearance, and significant enhancement of metastatic lung nodules (17.33 ± 8.39 vs. 2.0 ± 2.0, p = 0.03).”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
All animals in which mesenchymal stromal cells and osteosarcoma cells were co-implanted developed tumour by week 4, compared to those that received only osteosarcoma cells and developed tumour by week 6.
“All animals in which MSCs and osteosarcoma cells were co-implanted developed tumour by week 4, compared to those that received only osteosarcoma cells and developed tumour by week 6.”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
There was no significant statistical difference in tumour size after six weeks and in the number of metastases between the co-implanted and osteosarcoma-only groups.
“However, there was no significant statistical difference in tumour size after six weeks and in the number of metastases between the two groups.”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
The elevation of the basement membrane degrading enzymes MMP-2 and MMP-9 in mesenchymal stromal cells was connected with increased tumour metastasis.
“Moreover, the elevation of the basement membrane degrading enzymes, MMP-2 and MMP-9 in MSCs, was connected with increased tumour metastasis [95].”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
The overexpression of the CXCL12/CXCR7 axis was probably involved in osteosarcoma cell-mesenchymal stromal cell interaction that led to an increase in pulmonary metastases and tumour progression.
“The overexpression of the CXCL12/CXCR7 axis was probably involved in osteosarcoma cell-MSCs interaction that led to an increase in pulmonary metastases and tumour progression.”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [95]
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- Authors
- Honoki, K.
- Affiliations
- Nara Medical University (JP)
- Corresponding author
- Honoki, Kanya
- ORCID
- Honoki, Kanya
- Venue
- International Journal of Oncology
- Publisher
- Spandidos Publications
- Published
- 2011-10-03
- Volume
- 40
- Issue
- 1
- Pages
- 163-9
- ISSN
- 1019-6439 (ISSN-L)
- 1791-2423
- OpenAlex
- W2045576324
- Cited by
- 90
- References
- 54
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 7
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (20591765)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Keywords
- mesenchymal stem cells, osteosarcoma, metastasis, tumor microenvironment, tumor stroma, bone marrow-derived stem cells, lung metastasis, focal adhesions, integrins, ICAM, VCAM-1, gene expression profiling, tumor growth
- MeSH terms
- Animals, Bone Neoplasms, Cell Movement, Lung Neoplasms, Neoplasm Metastasis, Neoplasm Transplantation, Rats, Inbred F344, Osteosarcoma, Gene Expression Profiling, Mesenchymal Stem Cell Transplantation, Rats, Tumor Microenvironment, Mesenchymal Stem Cells
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