The role of gene polymorphisms in endometriosis
Open accessAbstract
Endometriosis is a benign gynecologic disorder, affecting up to 10% of women, characterized by the presence of functional endometrial tissue at ectopic positions generally within the peritoneum. It is a heritable condition influenced by multiple genetic and environmental factors, with an overall heritability estimated at approximately 50%. In this study, we investigated whether single nucleotide polymorphisms (SNPs) rs7521902, rs10859871 and rs11031006, mapping to WNT4, VEZT and FSHB genetic loci, respectively, are associated with risk for endometriosis in a Greek population. This study included 166 women with histologically confirmed endometriosis diagnosed through surgery and 150 normal controls. Genotyping of the rs7521902, rs10859871 and rs11031006 SNPs was performed with Taqman primer/probe sets. A significant association was detected with the AC genotype of rs7521902 (WNT4) in patients with stage III and IV disease only. Evidence for association with endometriosis was also found for the AC genotype of the rs10859871 of VEZT. Notably, a significant difference in the distribution of the AG genotype and the minor allele A of FSHB rs11031006 SNP was found between the endometriosis patients and controls. We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.
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Genome-wide association studies identified 10 or 15 loci with single-nucleotide polymorphisms associated with severe endometriosis, located in DNA sequences regulating target genes.
“Genomewide association studies identified 10 (50) or 15 (51) loci with single-nucleotide polymorphisms (52) associated with severe endometriosis, but located in DNA sequences regulating target genes (53).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [52]
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- Authors
- Matalliotakis, M., Zervou, M. I., Matalliotaki, C., Rahmioglu, N., Koumantakis, G., Kalogiannidis, I., Prapas, I., Zondervan, K., Spandidos, D. A., Matalliotakis, I., & Goulielmos, G. N.
- Affiliations
- The General Hospital of Heraklion "Venizeleio-Pananio" (GR)
- University of Crete (GR)
- Aristotle University of Thessaloniki (GR)
- Iakentro (GR)
- Centre for Human Genetics (GB)
- Corresponding author
- Goulielmos, George N.
- ORCID
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2017-05
- Volume
- 16
- Issue
- 5
- Pages
- 5881-5886
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- PMC
- PMC5865763
- OpenAlex
- W2752601165
- Cited by
- 75
- References
- 43
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 8
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Molecular Medicine Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Bayer
- University of Crete
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, single nucleotide polymorphisms, genetic susceptibility, Wnt4, follicle-stimulating hormone beta subunit, Greek population, disease stage, heritability
- MeSH terms
- Adult, Carrier Proteins, Endometriosis, Endometrium, Female, Genotype, Glycopeptides, Greece, Humans, Membrane Proteins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Association Studies, Wnt4 Protein
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