Cited by 130Metabolomics and Mass Spectrometry StudiesHealth, Environment, Cognitive AgingNutritional Studies and Diet

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Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods

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Lloyd, Amanda J, Favé, Gaëlle, Beckmann, Manfred, Lin, Wanchang, Tailliart, Kathleen, Xie, Long, Mathers, John C, Draper, John·2011·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.111.017921

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Abstract

Background The lack of robust biological markers of dietary exposure hinders the quantitative understanding of causal relations between diet and health.Objective We aimed to develop an efficient procedure to discover metabolites in urine that may have future potential as biomarkers of acute exposure to foods of high public health importance.Design Twenty-four participants were provided with a test breakfast in which the cereal component of a standardized breakfast was replaced by 1 of 4 foods of high public health importance; 1.5-, 3-, and 4.5-h postprandial urine samples were collected. Flow infusion electrospray-ionization mass spectrometry followed by supervised multivariate data analysis was used to discover signals resulting from consumption of each test food.Results Fasted-state urine samples provided a universal comparator for food biomarker lead discovery in postprandial urine. The filtering of data features associated with consumption of the common components of the standardized breakfast improved discrimination models and readily identified metabolites that showed consumption of specific test foods. A combination of trimethylamine-N-oxide and 1-methylhistidine was associated with salmon consumption. Novel ascorbate derivatives were discovered in urine after consumption of either broccoli or raspberries. Sulphonated caffeic acid and sulphonated methyl-epicatechin concentrations increased dramatically after consumption of raspberries.Conclusions This biomarker lead discovery strategy can identify urinary metabolites associated with acute exposure to individual foods. Future studies are required to validate the specificity and utility of potential biomarkers in an epidemiologic context.

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Authors: Lloyd, A. J., Favé, G., Beckmann, M., Lin, W., Tailliart, K., Xie, L., Mathers, J. C., & Draper, J.
Affiliations: Aberystwyth University (GB)
ORCID: Lloyd, Amanda J
Beckmann, Manfred
Xie, Long
Mathers, John C
Draper, John
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2011-10
Volume: 94
Issue: 4
Pages: 981-991
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.111.017921
OpenAlex: W2096891019
Cited by: 130
References: 48
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 15 · 2016: 13 · 2015: 7 · 2014: 13 · 2013: 19 · 2012: 9
FWCI: 5.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4162 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: urinary metabolites, salmon consumption, trimethylamine N-oxide, 1-methylhistidine, broccoli, raspberry, biomarker discovery
MeSH terms: Animals, Diet, Food, Humans, Kinetics, Gas Chromatography-Mass Spectrometry, ROC Curve, Biomarkers, Multivariate Analysis, Urinalysis, Postprandial Period, Spectrometry, Mass, Electrospray Ionization, Metabolomics, Metabolome, Data Mining

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Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods

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