Gut permeability, obesity, and metabolic disorders: who is the chicken and who is the egg

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.

Fasano, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2008 · Cited by 979 · see citing works

Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents

Santacruz, A., Marcos, A., Wärnberǵ, J., Martí, A., Martín‐Matillas, M., Campoy, C., Moreno, L. A., Veiga, Ó. L., Redondo-Figuero, C. G., Garagorri, J. M., et al. (2009) · Obesity · doi:10.1038/oby.2009.112 · Cited by 474 · see citing works

Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance

Moreno‐Navarrete, J. M., Sabater, M., Ortega, F. J., Ricart, W., & Fernández‐Real, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037160 · Cited by 302 · see citing works

Microbiota and Gut–Liver Axis: Their Influences on Obesity and Obesity‐Related Liver Disease

Vajro, P., Paolella, G., & Fasano, A. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318284abb5 · Cited by 201 · see citing works

Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction

Damms-Machado, A., Louis, S., Schnitzer, A., Volynets, V., Rings, A., Basrai, M., & Bischoff, S. C. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131110 · Cited by 195 · see citing works

Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders

Musso, G., Gambino, R., & Cassader, M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283347ebb · Cited by 182 · see citing works

Probiotic with or without Fiber Controls Body Fat Mass, Associated with Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial

Stenman, L. K., Lehtinen, M. J., Meland, N., Christensen, J. E., Yeung, N., Saarinen, M. T., Courtney, M., Burcelin, R., Lähdeaho, M.-L., Linros, J., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.036 · Cited by 177 · see citing works

α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities

Brüel, L., Sulzenbacher, G., Tison, M. C., Pujol, A., Nicoletti, C., Perrier, J., Galinier, A., Ropartz, D., Fons, M., Pompeo, F., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.286039 · Cited by 38 · see citing works

Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications

Chelakkot, C., Ghim, J., & Ryu, S. H. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0126-x · Cited by 2,017 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes

Reddy, P., Lent-Schochet, D., Ramakrishnan, N., McLaughlin, M., & Jialal, I. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.06.019 · Cited by 297 · see citing works

Association between blood microbiome and type 2 diabetes mellitus: A nested case‐control study

Qiu, J., Zhou, H. J., Yang, J., & Dong, C. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22842 · Cited by 131 · see citing works

Depression and Obesity: Analysis of Common Biomarkers

Milano, W., Ambrosio, P., Carizzone, F., Biasio, V. D., Munzio, W. D., Foia, M. G., & Capasso, A. (2020) · Diseases · doi:10.3390/diseases8020023 · Cited by 107 · see citing works

Pathways linking obesity to neuropsychiatric disorders

Martins, L. B., Monteze, N. M., Calarge, C. A., Ferreira, A. V. M., & Teixeira, A. L. (2019) · Nutrition · doi:10.1016/j.nut.2019.03.017 · Cited by 100 · see citing works

From Gut Microbiota through Low-Grade Inflammation to Obesity: Key Players and Potential Targets

Vetrani, C., Nisio, A. D., Paschou, S. Α., Barrea, L., Muscogiuri, G., Graziadio, C., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14102103 · Cited by 105 · see citing works

Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota

Robertson, R. C., Kaliannan, K., Strain, C., Ross, R. P., Stanton, C., & Kang, J. X. (2018) · Microbiome · doi:10.1186/s40168-018-0476-6 · Cited by 96 · see citing works

Lactobacillus fermentum CECT5716 ameliorates high fat diet-induced obesity in mice through modulation of gut microbiota dysbiosis

Molina‐Tijeras, J. A., Diez‐Echave, P., Vezza, T., Hidalgo‐Garcia, L., Ruiz‐Malagón, A. J., Rodríguez‐Sojo, M. J., Romero, M., Robles‐Vera, I., García, F., Plaza‐Díaz, J., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105471 · Cited by 98 · see citing works

Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota

Selma‐Royo, M., García‐Mantrana, I., Calatayud, M., Llorca, A. P., Martínez‐Costa, C., & Collado, M. C. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02337-7 · Cited by 74 · see citing works

Nutrition-based interventions for mood disorders

Martins, L. B., Tibães, J. R. B., Sanches, M., Jacka, F. N., Berk, M., & Teixeira, A. L. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1881482 · Cited by 77 · see citing works

Obesity related metabolic endotoxemia is associated with oxidative stress and impaired sperm DNA integrity

Pearce, K. L., Hill, A., & Tremellen, K. P. (2019) · Basic and Clinical Andrology · doi:10.1186/s12610-019-0087-5 · Cited by 61 · see citing works

The impact of a high fat diet on bones: potential mechanisms

Qiao, J., Wu, Y., & Ren, Y. (2020) · Food & Function · doi:10.1039/d0fo02664f · Cited by 57 · see citing works

Microbiota-independent immunological effects of non-digestible oligosaccharides in the context of inflammatory bowel diseases

Fabbro, S. D., Calder, P. C., & Childs, C. E. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120006953 · Cited by 38 · see citing works

Effects of probiotic and magnesium co-supplementation on mood, cognition, intestinal barrier function and inflammation in individuals with obesity and depressed mood: a randomized, double-blind placebo-controlled clinical trial

Mahboobi, S., Ghasvarian, M., Ghaem, H., Alipour, H., Alipour, S., & Eftekhari, M. H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1018357 · Cited by 31 · see citing works

Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats

Andrade, N., Marques, C., Andrade, S., Silva, C., Rodrigues, I., Guardão, L., Guimarães, J. T., Keating, E., Calhau, C., & Martel, F. (2019) · Food & Function · doi:10.1039/c9fo01142k · Cited by 27 · see citing works

The role of faecal microbiota transplantation in chronic noncommunicable disorders

Mullish, B. H., Tohumcu, E., Porcari, S., Fiorani, M., Tommaso, N. D., Gasbarrini, A., Cammarota, G., Ponziani, F. R., & Ianiro, G. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103034 · Cited by 25 · see citing works

Green banana flour supplementation improves obesity-associated systemic inflammation and regulates gut microbiota profile in mice fed high-fat diets

Rosado, C. P., Rosa, V. H. C., Martins, B. C., Soares, A. C., Almo, A., Monteiro, E. B., Mulder, A. D. R. P., Moura‐Nunes, N., & Daleprane, J. B. (2021) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2021-0288 · Cited by 24 · see citing works

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E. (2022) · Clinical Science · doi:10.1042/cs20211106 · Cited by 22 · see citing works

The impact of metabolic endotoxaemia on the browning process in human adipocytes

Omran, F., Murphy, A. M., Younis, A. Z., Kyrou, I., Vrbíková, J., Hainer, V., Šrámková, P., Fried, M., Ball, G., Tripathi, G., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02857-z · Cited by 21 · see citing works

Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice

Mujawdiya, P. K., Sharma, P., Sharad, S., & Kapur, S. (2020) · Pharmaceuticals · doi:10.3390/ph13080190 · Cited by 21 · see citing works

Gut microbiome links obesity to type 2 diabetes: insights from Mendelian randomization

Fu, L., Baranova, A. V., Cao, H., & Zhang, F. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03968-8 · Cited by 19 · see citing works

Higher bacterial DNAemia can affect the impact of a polyphenol-rich dietary pattern on biomarkers of intestinal permeability and cardiovascular risk in older subjects

Gargari, G., Taverniti, V., Bo’, C. D., Bernardi, S., Hidalgo‐Liberona, N., Meroño, T., Andrés‐Lacueva, C., Kroon, P. A., Cherubini, A., Riso, P., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02680-3 · Cited by 14 · see citing works

Relations of gut liver axis components and gut microbiota in obese children with fatty liver: A pilot study

Pierri, L., Saggese, P., Nuzio, S. G., Troisi, J., Stasi, M. D., Poeta, M., Savastano, R., Marchese, G., Tarallo, R., Massa, G., et al. (2018) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2018.03.015 · Cited by 14 · see citing works

Role of Gut Microbiota in Overweight Susceptibility in an Adult Population in Italy

Politi, C., Mobrici, M., Parlongo, R. M., Spoto, B., Tripepi, G. L., Pizzini, P., Cutrupi, S., Franco, D., Tino, R., Farruggio, G., et al. (2023) · Nutrients · doi:10.3390/nu15132834 · Cited by 13 · see citing works

Melatonin-mediated corrective changes in gut microbiota of experimentally chronodisrupted C57BL/6J mice

Vohra, A., Karnik, R., Desai, M. R., Vyas, H., Kulshrestha, S., Upadhyay, K. K., KORINGA, P. G., & Devkar, R. (2024) · Chronobiology International · doi:10.1080/07420528.2024.2329205 · Cited by 15 · see citing works

Effect of a carotenoid-producing Bacillus strain on intestinal barrier integrity and systemic delivery of carotenoids: A randomised trial in animals and humans

Stevens, Y., Pinheiro, I., Salden, B. N., Duysburgh, C., Bolca, S., Degroote, J., Majdeddin, M., Noten, N. V., Gleize, B., Caris, C., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104445 · Cited by 12 · see citing works

Is type 2 diabetes mellitus another intercellular junction-related disorder?

Collares‐Buzato, C. B., & Carvalho, C. P. D. F. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221090464 · Cited by 12 · see citing works

A Physiologically Relevant Dose of 50% Egg-Phosphatidylcholine Is Sufficient in Improving Gut Permeability while Attenuating Immune Cell Dysfunction Induced by a High-Fat Diet in Male Wistar Rats

Rusnak, T., Azarcoya‐Barrera, J., Wollin, B., Makarowski, A., Nelson, R., Field, C. J., Jacobs, R. L., & Richard, C. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.08.010 · Cited by 11 · see citing works

The Intersection of Maternal Metabolic Syndrome, Adverse Pregnancy Outcomes, and Future Metabolic Health for the Mother and Offspring

Girardi, G., & Bremer, A. A. (2022) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2021.0124 · Cited by 11 · see citing works

Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice

Ramírez-Maldonado, L. M., Guerrero-Castro, J., Rodríguez-Mejía, J. L., Cárdenas‐Conejo, Y., Bonales-Alatorre, E. O., Valencia-Cruz, G., Anguiano-García, P. T., Vega-Juarez, I. I., Dagnino-Acosta, A., Ruvalcaba-Galindo, J., et al. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00198.2024 · Cited by 9 · see citing works

Intestinal permeability before and after albendazole treatment in low and high socioeconomic status schoolchildren in Makassar, Indonesia

Amaruddin, A. I., Koopman, J. P. R., Muhammad, M., Lenaerts, K., van Eijk, H. M. H., Brienen, E. A. T., Geelen, A. R., van Lieshout, L., Wahyuni, S., Kuijper, E. J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07086-7 · Cited by 7 · see citing works

Intestinal barrier disorders and metabolic endotoxemia in obesity: Current knowledge

Potrykus, M., Szymański, M., Kaska, Ł., & Janczy, A. (2022) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.2478/ahem-2022-0008 · Cited by 7 · see citing works

Intestinal permeability and low-grade chronic inflammation in schizophrenia: A multicentre study on biomarkers. Rationale, objectives, protocol and preliminary results

Anmella, G., Amoretti, S., Safont, G., Meseguer, A., Vieta, E., Pons-Cabrera, M. T., Alfonso, M., Hernández, C., Sánchez-Autet, M., Pérez-Baldellou, F., et al. (2023) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.sjpmh.2023.09.005 · Cited by 6 · see citing works

The Role of Palmitic Acid in the Co-Toxicity of Bacterial Metabolites to Endothelial Cells

Choroszy, M., Środa-Pomianek, K., Wawrzyńska, M., Chmielarz, M., Bożemska, E., & Sobieszczańska, B. (2023) · Vascular Health and Risk Management · doi:10.2147/vhrm.s408897 · Cited by 5 · see citing works

Összefüggés a bél-hiperpermeabilitás és az elhízás között

Ságodi, L., Sólyom, E., Ságodi, L., & Almási, A. (2022) · Orvosi Hetilap · doi:10.1556/650.2022.32542 · Cited by 4 · see citing works

Endotoxemia And Intestinal Barrier Disorders Associated With Overweight And Obesity

Janczy, A., Kochan, Z., & Małgorzewicz, S. (2019) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.21307/pm-2019.58.4.427 · Cited by 4 · see citing works

Obesity and Cancer Risk

Castro, N., Silva, L. B. A. R., & Ong, T. P. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788016506-00147 · Cited by 2 · see citing works

Effects of Consumption of Caged and Un-Caged Chicken Meat on Ovarian Health of Female Wistar Rats

Ahmad, S., Ahmed, I., Haider, S., Batool, Z., Ahmed, F., Tabassum, S., Madiha, S., Perveen, T., & Ahmed, S. B. (2018) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/2018.50.2.487.493 · Cited by 2 · see citing works

Phytotherapy for Obesity Management: The Role of Gut Microbiota in Reshaping Adipose Tissue

Wang, H., Zhang, D., & Cheng, L. (2025) · Phytotherapy Research · doi:10.1002/ptr.70066 · Cited by 1 · see citing works

Is the Immunogenic Action of Gluten Enough to Aggravate Obesity in Non-coeliac Individuals?

Alvarez-Leite, J. I. (2017) · Nutrition & Food Science International journal · doi:10.19080/nfsij.2017.02.555596 · Cited by 1 · see citing works

Metabolic Pathways Underlying Neuropsychiatric Disorders and Obesity

Martins, L. B., Maurício, S. F., Ferreira, A. V. M., & Teixeira, A. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_30 · Cited by 1 · see citing works

Additional file 1 of The impact of metabolic endotoxaemia on the browning process in human adipocytes

Omran, F., Murphy, A. M., Younis, A. Z., Kyrou, I., Vrbíková, J., Hainer, V., Šrámková, P., Fried, M., Ball, G., Tripathi, G., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22662434

Additional file 2 of The impact of metabolic endotoxaemia on the browning process in human adipocytes

Omran, F., Murphy, A. M., Younis, A. Z., Kyrou, I., Vrbíková, J., Hainer, V., Šrámková, P., Fried, M., Ball, G., Tripathi, G., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22662437

Permeabilidade intestinal e parâmetros nutricionais e bioquímicos na obesidade

Teixeira, T. F. S. (2010) · Americanae (AECID Library)

Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity

Gasmi, A. (2021) · Current Medicinal Chemistry · doi:10.2174/1875533xmta4jmzkpx · Cited by 2 · see citing works

Obesity's Chicken or Egg

Stern, P. (2011) · Science · doi:10.1126/science.332.6025.15-a

Is intestinal permeability increased in obesity? A review including the effects of dietary, pharmacological and surgical interventions on permeability and the microbiome

Camilleri, M. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14899 · Cited by 22 · see citing works

Pyruvate Metabolism in Obesity

Miller, A. T., & Thomas, B. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.6.619 · Cited by 6 · see citing works