The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
Open accessAbstract
Background Anthocyanins have been shown to exert benefits on the lipid profile in many animal models. Whether these molecules have similar beneficial effects in humans is currently unknown.Objective The objective was to investigate the effects of berry-derived anthocyanin supplements on the serum lipid profile in dyslipidemic patients.Design A total of 120 dyslipidemic subjects (age 40-65 y) were given 160 mg anthocyanins twice daily or placebo for 12 wk in a double-blind, randomized, placebo-controlled trial.Results Anthocyanin consumption increased HDL-cholesterol concentrations (13.7% and 2.8% in the anthocyanin and placebo groups, respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6% and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001). Cellular cholesterol efflux to serum increased more in the anthocyanin group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001). Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3%, respectively, in the anthocyanin group and -3.5% and 1.1%, respectively, in the placebo group; P < 0.001). In the anthocyanin group, the change in HDL cholesterol was negatively correlated with the change in CETP activity (r(s) = -0.330). The change in LDL cholesterol was positively correlated with the change in CETP mass (r(s) = 0.354). The change in cellular cholesterol efflux to serum was positively correlated with the change in HDL cholesterol (r(s) = 0.485). In vitro, cyanidin 3-O-beta-glucosides dose-dependently lowered CETP activity in human HepG2 cells.Conclusions Anthocyanin supplementation in humans improves LDL- and HDL-cholesterol concentrations and enhances cellular cholesterol efflux to serum. These benefits may be due to the inhibition of CETP.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Since some clinical studies have also found antidiabetic and antihyperlipidemic effects of encapsulated berry supplements, these forms may be suitable for the management of specific metabolic conditions.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [50]
Citations
Cites
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport
Lewis, G. F., & Rader, D. J. (2005) · Circulation Research · doi:10.1161/01.res.0000170946.56981.5c · Cited by 1,104
Fruit and vegetable intake and risk of cardiovascular disease: The women’s health study
Liu, S., Manson, J. E., Lee, I.-M., Cole, S. R., Hennekens, C. H., Willett, W. C., & Buring, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.922 · Cited by 917
Assmann, G., & Schulte, H. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90550-i · Cited by 872
Inazu, A., Brown, M. L., Hesler, C. B., Agellon, L. B., Koizumi, J., Takata, K., Maruhama, Y., Mabuchi, H., & Tall, A. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231803 · Cited by 862
Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol
Brousseau, M. E., Schaefer, E. J., Wolfe, M. L., Bloedon, L. T., Digenio, A. G., Clark, R. W., Mancuso, J. P., & Rader, D. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031766 · Cited by 774
High Density Lipoproteins and Arteriosclerosis
von Eckardstein, A., Nofer, J., & Assmann, G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.1.13 · Cited by 696
HDL Cholesterol and Protective Factors in Atherosclerosis
Assmann, G., & Gotto, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000131512.50667.46 · Cited by 637
The bioavailability and absorption of anthocyanins: Towards a better understanding
McGhie, T. K., & Walton, M. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700092 · Cited by 617
Antioxidant Activity of Dietary Fruits, Vegetables, and Commercial Frozen Fruit Pulps
Hassimotto, N. M. A., Genovese, M. I., & Lajolo, F. M. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf047894h · Cited by 525
Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., & Jula, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.323 · Cited by 445
Karlsen, A. S., Retterstøl, L., Laake, P., Paur, I., Kjølsrud-Bøhn, S., Sandvik, L., & Blomhoff, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1951 · Cited by 399
Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1911 · Cited by 376
Anthocyanins as Antioxidants on Human Low-Density Lipoprotein and Lecithin−Liposome Systems
Satué-Gracia, M. T., Heinonen, M., & Frankel, E. N. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf970234a · Cited by 368
Mozaffarian, D., Kumanyika, S., Lemaître, R. N., Olson, J. L., Burke, G. L., & Siscovick, D. S. (2003) · JAMA · doi:10.1001/jama.289.13.1659 · Cited by 289
Ling, W. H., Cheng, Q. X., Ma, J., & Wang, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1421 · Cited by 237
Xia, X., Ling, W., Ma, J., Xia, M., Hou, M., Wang, Q., Zhu, H., & Tang, Z. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2220 · Cited by 232
Nöthlings, U., Schulze, M. B., Weikert, C., Boeing, H., van der Schouw, Y. T., Bamia, C., Benetou, V., Λάγιου, Π., Krogh, V., Beulens, J. W. J., et al. (2008) · Journal of Nutrition · doi:10.1093/jn/138.4.775 · Cited by 227
Xu, J.-W., Ikeda, K., & Yamori, Y. (2004) · Hypertension · doi:10.1161/01.hyp.0000135868.38343.c6 · Cited by 197
Xia, M., Ling, W. H., Ma, J., Kitts, D. D., & Zawistowski, J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.744 · Cited by 157
Brown, B. G., Stukovsky, K. H., & Zhao, X.-Q. (2006) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32800ff750 · Cited by 155
Hansen, A. S., Marckmann, P., Dragsted, L. O., Nielsen, I. L. F., Nielsen, S. E., & Grønbæk, M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602107 · Cited by 153
Toshihide, N., & Yasuo, A. (1977) · Clinica Chimica Acta · doi:10.1016/0009-8981(77)90355-2 · Cited by 151
Anthocyanins Induce Cholesterol Efflux from Mouse Peritoneal Macrophages
Xia, M., Hou, M., Zhu, H., Ma, J., Tang, Z., Wang, Q., Li, Y., Chi, D.-S., Yu, X., Zhao, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505047200 · Cited by 147
Tsuda, T., Horio, F., Kitoh, J., & Osawa, T. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1311 · Cited by 145
Illuminating HDL — Is It Still a Viable Therapeutic Target?
Rader, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejme0707210 · Cited by 119
Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non‐HDL to HDL cholesterol
Lam, C. K., Zhang, Z., Yu, H., Tsang, S. Y., Huang, Y., & Chen, Z. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700319 · Cited by 84
Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1
Beulens, J. W. J., Sierksma, A., van Tol, A., Fournier, N., van Gent, T., Paul, J. L., & Hendriks, H. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400109-jlr200 · Cited by 77
Fournier, N., Francone, O. L., Rothblat, G. H., Goudounèche, D., Cambillau, M., Kellner-Weibel, G., Robinet, P., Royer, L. J., MOATTI, N., Simon, A. C., et al. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.08.011 · Cited by 44
SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome
Yancey, P. G., Asztalos, B. F., Stettler, N., Piccoli, D. A., Williams, D. L., Connelly, M. A., & Rothblat, G. H. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400133-jlr200 · Cited by 37
Use of fluorescent cholesteryl ester microemulsions in cholesteryl ester transfer protein assays
Bisgaier, C. L., Minton, L. L., Essenburg, A., White, A. D., & Homan, R. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36955-8 · Cited by 37
Pape, M. E., Ulrich, R. G., Rea, T. J., Marotti, K. R., & Melchior, G. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98766-1 · Cited by 32
Cited by
Sorted by citations
Khoo, H. E., Azlan, A., Tang, S. T., & Lim, S. M. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1361779 · Cited by 3,205
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Mattioli, R., Francioso, A., Mosca, L., & Silva, P. (2020) · Molecules · doi:10.3390/molecules25173809 · Cited by 1,145
The Case for Anthocyanin Consumption to Promote Human Health: A Review
Pojer, E., Mattivi, F., Johnson, D., & Stockley, C. S. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12024 · Cited by 657
Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 623
Metadata
- Authors
- Qin, Y., Xia, M., Ma, J., Hao, Y., Liu, J., Mou, H., Cao, L., & Ling, W.
- Corresponding author
- Ling, WenHua
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 90
- Issue
- 3
- Pages
- 485-492
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2153378467
- Cited by
- 443
- References
- 35
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 18 · 2023: 22 · 2022: 26 · 2021: 41 · 2020: 48 · 2019: 32 · 2018: 33 · 2017: 23 · 2016: 33 · 2015: 20 · 2014: 27 · 2013: 35 · 2012: 20
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- anthocyanins, dyslipidemia, LDL cholesterol, HDL cholesterol, cholesteryl ester transfer protein, CETP inhibition, cholesterol efflux, lipid profile, cyanidin-3-glucoside, HepG2 cells
- MeSH terms
- Adult, Aged, Anthocyanins, Biological Transport, Cell Line, Dose-Response Relationship, Drug, Double-Blind Method, Female, Fruit, Glucosides, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Phytotherapy, Middle Aged, Plant Extracts, Dietary Supplements, Dyslipidemias, Cholesterol Ester Transfer Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
