Cited by 443Phytochemicals and Antioxidant ActivitiesNatural Products and Biological ResearchCholesterol and Lipid Metabolism

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Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects

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Qin, Yu, Xia, Min, Ma, Jing, Hao, YuanTao, Liu, Jing, Mou, HaiYing, Cao, Li, Ling, WenHua·2009·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2009.27814

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Abstract

Background Anthocyanins have been shown to exert benefits on the lipid profile in many animal models. Whether these molecules have similar beneficial effects in humans is currently unknown.Objective The objective was to investigate the effects of berry-derived anthocyanin supplements on the serum lipid profile in dyslipidemic patients.Design A total of 120 dyslipidemic subjects (age 40-65 y) were given 160 mg anthocyanins twice daily or placebo for 12 wk in a double-blind, randomized, placebo-controlled trial.Results Anthocyanin consumption increased HDL-cholesterol concentrations (13.7% and 2.8% in the anthocyanin and placebo groups, respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6% and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001). Cellular cholesterol efflux to serum increased more in the anthocyanin group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001). Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3%, respectively, in the anthocyanin group and -3.5% and 1.1%, respectively, in the placebo group; P < 0.001). In the anthocyanin group, the change in HDL cholesterol was negatively correlated with the change in CETP activity (r(s) = -0.330). The change in LDL cholesterol was positively correlated with the change in CETP mass (r(s) = 0.354). The change in cellular cholesterol efflux to serum was positively correlated with the change in HDL cholesterol (r(s) = 0.485). In vitro, cyanidin 3-O-beta-glucosides dose-dependently lowered CETP activity in human HepG2 cells.Conclusions Anthocyanin supplementation in humans improves LDL- and HDL-cholesterol concentrations and enhances cellular cholesterol efflux to serum. These benefits may be due to the inhibition of CETP.

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Authors: Qin, Y., Xia, M., Ma, J., Hao, Y., Liu, J., Mou, H., Cao, L., & Ling, W.
Corresponding author: Ling, WenHua
ORCID: Xia, Min
Ma, Jing
Hao, YuanTao
Liu, Jing
Cao, Li
Ling, WenHua
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2009-09
Volume: 90
Issue: 3
Pages: 485-492
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2009.27814
OpenAlex: W2153378467
Cited by: 443
References: 35
Citations by year: 2026: 9 · 2025: 23 · 2024: 18 · 2023: 22 · 2022: 26 · 2021: 41 · 2020: 48 · 2019: 32 · 2018: 33 · 2017: 23 · 2016: 33 · 2015: 20 · 2014: 27 · 2013: 35 · 2012: 20
FWCI: 11.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4922 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: anthocyanins, dyslipidemia, LDL cholesterol, HDL cholesterol, cholesteryl ester transfer protein, CETP inhibition, cholesterol efflux, lipid profile, cyanidin-3-glucoside, HepG2 cells
MeSH terms: Adult, Aged, Anthocyanins, Biological Transport, Cell Line, Dose-Response Relationship, Drug, Double-Blind Method, Female, Fruit, Glucosides, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Phytotherapy, Middle Aged, Plant Extracts, Dietary Supplements, Dyslipidemias, Cholesterol Ester Transfer Proteins

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Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects

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