The effects of 30-days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
Open accessAbstract
Polyphenolic compounds, such as resveratrol, have recently received widespread interest because of their ability to mimic effects of calorie restriction. The objective of the present study was to gain more insight into the effects of 30 days resveratrol supplementation on adipose tissue morphology and underlying processes. Eleven healthy obese men were supplemented with placebo and resveratrol for 30 days (150 mg per day), separated by a 4-week washout period in a double-blind randomized crossover design. A postprandial abdominal subcutaneous adipose tissue biopsy was collected to assess adipose tissue morphology and gene expression using microarray analysis. Resveratrol significantly decreased adipocyte size, with a shift toward a reduction in the proportion of large and very-large adipocytes and an increase in small adipocytes. Microarray analysis revealed downregulation of Wnt and Notch signaling pathways and upregulation of pathways involved in cell cycle regulation after resveratrol supplementation, suggesting enhanced adipogenesis. Furthermore, lysosomal/phagosomal pathway and transcription factor EB were upregulated reflecting an alternative pathway of lipid breakdown by autophagy. Further research is necessary to investigate whether resveratrol improves adipose tissue function.
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Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
TFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365 · see citing works
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703 · see citing works
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works
Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320 · see citing works
Self-citationAutophagy regulates adipose mass and differentiation in mice
Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 748 · see citing works
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591 · see citing works
Self-citationLipophagy: Connecting Autophagy and Lipid Metabolism
Singh, R., & Cuervo, A. M. (2012) · International Journal of Cell Biology · doi:10.1155/2012/282041 · Cited by 497 · see citing works
High-Dose Resveratrol Supplementation in Obese Men
Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455 · see citing works
Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S., Schechtman, K. B., Gu, C. C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 381 · see citing works
McLaughlin, T., Sherman, A., Tsao, P., Gonzalez, O., Yee, G., Lamendola, C., Reaven, G. M., & Cushman, S. W. (2007) · Diabetologia · doi:10.1007/s00125-007-0708-y · Cited by 364 · see citing works
Singh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C. C., Weinman, E. J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35541 · Cited by 364 · see citing works
Resveratrol, obesity and diabetes
Szkudelska, K., & Szkudelski, T. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.02.054 · Cited by 342 · see citing works
Bråkenhielm, E., Cao, R., & Cao, Y. (2001) · The FASEB Journal · doi:10.1096/fj.01-0028fje · Cited by 334 · see citing works
Kim, S., Jin, Y., Choi, Y., & Park, T. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.03.012 · Cited by 332 · see citing works
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works
Self-citationHe, Q., Gao, Z., Yin, J., Zhang, J., Yun, Z., & Ye, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00626.2010 · Cited by 245 · see citing works
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
Fischer-Posovszky, P., Kukulus, V., Tews, D., Unterkircher, T., Debatin, K.-M., Fulda, S., & Wabitsch, M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28435 · Cited by 195 · see citing works
Christodoulides, C., Laudes, M., Cawthorn, W. P., Schinner, S., Soos, M. A., O’Rahilly, S., Sethi, J. K., & Vidal‐Puig, A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02975 · Cited by 160 · see citing works
Garcés, C., Ruiz‐Hidalgo, M. J., de Mora, J. F., Park, C., Miele, L., Goldstein, J., Bonvini, E., Porrás, A., & Laborda, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29729 · Cited by 152 · see citing works
Šiklová, M., Klimčáková, E., Polak, J., Kováčová, Z., Tencerová, M., Rossmeislová, L., Bajzová, M., Langin, D., & Štich, V. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2380 · Cited by 37 · see citing works
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Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523 · see citing works
Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review
Amiot, M. J., Riva, C., & Vinet, A. (2016) · Obesity Reviews · doi:10.1111/obr.12409 · Cited by 448 · see citing works
Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
Musso, G., Cassader, M., & Gambino, R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.3 · Cited by 415 · see citing works
Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity
Springer, M., & Moco, S. (2019) · Nutrients · doi:10.3390/nu11010143 · Cited by 293 · see citing works
Wang, S., Liang, X., Yang, Q., Fu, X., Rogers, C. J., Zhu, M. J., Rodgers, B. D., Jiang, Q., Dodson, M. V., & Du, . (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.23 · Cited by 280 · see citing works
Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities
Boccellino, M., & D’Angelo, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165642 · Cited by 265 · see citing works
Resveratrol, Metabolic Syndrome, and Gut Microbiota
Chaplin, A. M. L., Carpéné, C., & Mercader, J. (2018) · Nutrients · doi:10.3390/nu10111651 · Cited by 248 · see citing works
Resveratrol supplementation: Where are we now and where should we go?
Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., & de Cabo, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.002 · Cited by 247 · see citing works
Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene
Tsai, H.-Y., Ho, C., & Chen, Y. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.07.004 · Cited by 236 · see citing works
The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity
Zhao, Y., Chen, B., Shen, J., Wan, L., Zhu, Y., Yi, T., & Xiao, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1459497 · Cited by 214 · see citing works
Brown, K., Theofanous, D., Britton, R. G., Aburido, G., Pepper, C., Undru, S. S., & Howells, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020747 · Cited by 190 · see citing works
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works
Self-citationAdvances in Understanding of the Role of Lipid Metabolism in Aging
Chung, K. W. (2021) · Cells · doi:10.3390/cells10040880 · Cited by 185 · see citing works
Functional foods as potential therapeutic options for metabolic syndrome
Brown, L., Poudyal, H., & Panchal, S. K. (2015) · Obesity Reviews · doi:10.1111/obr.12313 · Cited by 159 · see citing works
Anti-aging pharmacology: Promises and pitfalls
Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 144 · see citing works
Resveratrol, human health and winemaking perspectives
Pastor, R. F., Restani, P., Di Lorenzo, C., Orgiu, F., Teissedre, P.-L., Stockley, C., Ruf, J. C., Quini, C. I., Garcìa Tejedor, N., Gargantini, R., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1400517 · Cited by 123 · see citing works
Autophagy in Human Health and Disease: Novel Therapeutic Opportunities
Giampieri, F., Afrin, S., Forbes-Hernández, T. Y., Gasparrini, M., Cianciosi, D., Reboredo‐Rodríguez, P., Varela‐López, A., Quiles, J. L., & Battino, M. A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7234 · Cited by 117 · see citing works
Fernández, Á. F., Bárcena, C., Martínez-García, G. G., Tamargo-Gómez, I., Suárez, M. F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., et al. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.373 · Cited by 109 · see citing works
Metabolic effects of resveratrol: Addressing the controversies
Bitterman, J. L., & Chung, J. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1808-8 · Cited by 109 · see citing works
Significance of Resveratrol in Clinical Management of Chronic Diseases
Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017) · Molecules · doi:10.3390/molecules22081329 · Cited by 108 · see citing works
Ye, R. Z., Richard, G. M., Gévry, N. Y., Tchernof, A., & Carpentier, A. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab018 · Cited by 105 · see citing works
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Peña‐Oyarzún, D., Bravo, R., Díaz‐Vegas, A., Aleman, L., Chiong, M., Garcı́a, L., Claudia Bambs, S., Troncoso, R., Cifuentes, M., Morselli, E., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.084 · Cited by 101 · see citing works
Wang, S., Liang, X., Yang, Q., Fu, X., Zhu, M. J., Rodgers, B. D., Jiang, Q., Dodson, M. V., & Du, . (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600746 · Cited by 98 · see citing works
Aamir, K., Khan, H. U., Sethi, G., Hossain, M. A., & Arya, A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104602 · Cited by 97 · see citing works
Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene
Pan, M., Wu, J.-C., Ho, C., & Lai, C. (2018) · BioFactors · doi:10.1002/biof.1409 · Cited by 92 · see citing works
Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease
Dhakal, S., Kushairi, N., Phan, C., Adhikari, B., Sabaratnam, V., & Macreadie, I. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205090 · Cited by 89 · see citing works
Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review
Barber, T. M., Kabisch, S., Randeva, H. S., Pfeiffer, A. F. H., & Weickert, M. O. (2022) · Nutrients · doi:10.3390/nu14142870 · Cited by 83 · see citing works
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review
Mele, L., Bidault, G., Mena, P. R., Crozier, A., Brighenti, F., Vidal‐Puig, A., & Rio, D. D. (2017) · Advances in Nutrition · doi:10.3945/an.117.015792 · Cited by 81 · see citing works
Cytoprotective Effects of Natural Compounds against Oxidative Stress
Mehta, J., Rayalam, S., & Wang, X. (2018) · Antioxidants · doi:10.3390/antiox7100147 · Cited by 80 · see citing works
Józkowiak, M., Hutchings, G., Jankowski, M., Kulcenty, K. I., Mozdziak, P. E., Kempisty, B., Spaczyński, R., & Piotrowska‐Kempisty, H. (2020) · Cells · doi:10.3390/cells9061418 · Cited by 76 · see citing works
Effect of resveratrol on metabolic syndrome components: A systematic review and meta-analysis
Asgary, S., Karimi, R., Momtaz, S., Naseri, R., & Farzaei, M. H. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09494-z · Cited by 76 · see citing works
Liu, C., Liao, J., & Li, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i11.1964 · Cited by 75 · see citing works
Chupradit, S., Bokov, D. O., Zamanian, M. Y., Heidari, M., & Hakimizadeh, E. (2021) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12746 · Cited by 75 · see citing works
Pascual‐Serrano, A., Arola‐Arnal, A., Suárez‐Garcia, S., Bravo, F. I., Suárez, M., Arola, L., & Bladé, C. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.90 · Cited by 73 · see citing works
The Role of Resveratrol Administration in Human Obesity
Mongioì, L. M., La Vignera, S., Cannarella, R., Cimino, L., Compagnone, M., Condorelli, R. A., & Calogero, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094362 · Cited by 71 · see citing works
Deciphering the Anti-obesity Benefits of Resveratrol: The “Gut Microbiota-Adipose Tissue” Axis
Zhou, L., Xiao, X., Zhang, Q., Zheng, J., & Deng, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00413 · Cited by 66 · see citing works
Navarro, G., Martínez‐Pinilla, E., Ortiz, R., Noé, V., Ciudad, C. J., & Franco, R. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12359 · Cited by 63 · see citing works
Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies
Papagianis, P. C., Pillow, J. J., & Moss, T. J. M. (2018) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2018.07.007 · Cited by 60 · see citing works
Walker, J. M., Eckardt, P. A., Alemán, J. O., da Rosa, J. C., Liang, Y., Iizumi, T., Etheve, S., Blaser, M. J., Breslow, J. L., & Holt, P. R. (2018) · Journal of Clinical and Translational Research · doi:10.18053/jctres.04.201802.004 · Cited by 60 · see citing works
Resveratrol supplementation reduces ACE2 expression in human adipose tissue
de Ligt, M., Hesselink, M. K. C., Jörgensen, J. A., Hoebers, N., Blaak, E. E., & Goossens, G. H. (2021) · Adipocyte · doi:10.1080/21623945.2021.1965315 · Cited by 59 · see citing works
Self-citationPhytochemicals for the treatment of metabolic diseases: Evidence from clinical studies
Luo, Y., Zeng, Y., Peng, J., Zhang, K., Wang, L., Feng, T., Nhamdriel, T., & Fan, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115274 · Cited by 58 · see citing works
The Potential to Fight Obesity with Adipogenesis Modulating Compounds
Zhao, J., Zhou, A., & Qi, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042299 · Cited by 54 · see citing works
Most, J., Warnke, I., Boekschoten, M. V., Jocken, J. W. E., de Groot, P., Friedel, A., Bendik, I., Goossens, G. H., & Blaak, E. E. (2018) · Adipocyte · doi:10.1080/21623945.2018.1469942 · Cited by 54 · see citing works
Self-citationResveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization
Carpéné, C., Les, F., Cásedas, G., Peiro, C., Fontaine, J., Chaplin, A. M. L., Mercader, J., & López, V. (2019) · Antioxidants · doi:10.3390/antiox8030074 · Cited by 53 · see citing works
García-Aguilar, A., Palomino, O. M., Benito, M., & Guillén, C. (2021) · Antioxidants · doi:10.3390/antiox10020142 · Cited by 52 · see citing works
Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases
Cote, B., Elbarbry, F., Bui, F. Q., Su, J. W., Seo, K., Nguyen, A., Lee, M., & Rao, D. A. (2022) · Molecules · doi:10.3390/molecules27030781 · Cited by 53 · see citing works
Antiobesity effects of resveratrol: which tissues are involved?
Fernández‐Quintela, A., Milton‐Laskibar, I., González, M. A., & Portillo, M. P. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13413 · Cited by 51 · see citing works
Kim, O. Y., Chung, J. Y., & Song, J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104411 · Cited by 47 · see citing works
A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity
Siddiqui, S. A., Harahap, I. A., Suthar, P., Wu, Y. S., Ghosh, N., & Castro‐Muñoz, R. (2023) · Foods · doi:10.3390/foods12193610 · Cited by 43 · see citing works
Nutraceuticals and regulation of adipocyte life: Premises or promises
Colitti, M., & Grasso, S. (2014) · BioFactors · doi:10.1002/biof.1164 · Cited by 43 · see citing works
Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens
Kuryłowicz, A., Cakala, M., & Puzianowska‐Kuźnicka, M. (2020) · Nutrients · doi:10.3390/nu12020582 · Cited by 43 · see citing works
Tallis, J. A., Shelley, S. P., Degens, H., & Hill, C. (2021) · Biomolecules · doi:10.3390/biom11030372 · Cited by 44 · see citing works
In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins
Kuryłowicz, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040572 · Cited by 43 · see citing works
Chung, Y. W., Ahmad, F., Tang, Y., Hockman, S. C., Kee, H. J., Berger, K., Guirguis, E., Choi, Y. H., Schimel, D., Aponte, A. M., et al. (2017) · Scientific Reports · doi:10.1038/srep40445 · Cited by 43 · see citing works
Anti-obesity effects of resveratrol: comparison between animal models and humans
Fernández‐Quintela, A., Carpéné, C., Fernández, M., Aguirre, L., Milton‐Laskibar, I., Contreras, J., & Portillo, M. P. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-016-0544-y · Cited by 41 · see citing works
The Preventive Mechanisms of Bioactive Food Compounds against Obesity-Induced Inflammation
Pelczyńska, M., Moszak, M., Wesołek, A., & Bogdański, P. (2023) · Antioxidants · doi:10.3390/antiox12061232 · Cited by 40 · see citing works
Alsharif, I., Boukhzar, L., Lefranc, B., Godefroy, D., Aury‐Landas, J., do Rego, J. L., do-Rego, J.-C., Naudet, F., Arabo, A., Chagraoui, A., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101839 · Cited by 40 · see citing works
Resveratrol improves muscle regeneration in obese mice through enhancing mitochondrial biogenesis
Niu, W., Wang, H., Wang, B., Mao, X., & Du, M. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108804 · Cited by 39 · see citing works
Sadi, G., Baloğlu, M. C., & Pektaş, M. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124968 · Cited by 39 · see citing works
Liudvytska, O., & Kołodziejczyk-Czepas, J. (2022) · Nutrients · doi:10.3390/nu14102053 · Cited by 39 · see citing works
How to Take Autophagy and Endocytosis Up a Notch
Barth, J. M. I., & Köhler, K. (2014) · BioMed Research International · doi:10.1155/2014/960803 · Cited by 38 · see citing works
Lin, C., Sun, X., & Lin, A.-X. (2016) · Renal Failure · doi:10.3109/0886022x.2015.1128236 · Cited by 38 · see citing works
Physiologically achievable doses of resveratrol enhance 3T3-L1 adipocyte differentiation
Hu, P., Zhao, L., & Chen, J. (2015) · European Journal of Nutrition · doi:10.1007/s00394-014-0738-4 · Cited by 35 · see citing works
Nishimura, Y., Sasagawa, S., Ariyoshi, M., Ichikawa, S., Shimada, Y., Kawaguchi, K., Kawase, R., Yamamoto, R., Uehara, T., Yanai, T., et al. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00199 · Cited by 36 · see citing works
Hijona, E., Aguirre, L., Pérez‐Matute, P., Villanueva-Millán, M. J., Mosqueda-Solís, A., Hasnaoui, M., Nepveu, F., Sénard, J., Bujanda, L., Aldamiz-Echevarria, L. J., et al. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0464-2 · Cited by 35 · see citing works
Targeting dysregulated lipid metabolism in the tumor microenvironment
Kim, D., Song, N., & Yim, H. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01473-y · Cited by 35 · see citing works
The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes
Ku, C. R., Cho, Y. H., Hong, Z.-Y., Lee, H., Lee, S. J., Hong, S. S., & Lee, E. J. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.328 · Cited by 32 · see citing works
Reguero, M., de Cedrón, M. G., Wagner, S., Reglero, G., Quintela, J. C., & de Molina, A. R. (2021) · Cancers · doi:10.3390/cancers13040866 · Cited by 31 · see citing works
Wang, Z., Quan, W., Zeng, M., Wang, Z., Chen, Q., Chen, J., Christian, M., & He, Z. (2023) · Food Frontiers · doi:10.1002/fft2.255 · Cited by 31 · see citing works
Rossi, E. L., Khatib, S. A., Doerstling, S. S., Bowers, L. W., Pruski, M. A., Ford, N. A., Glickman, R. D., Niu, M., Yang, P., Cui, Z., et al. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22763 · Cited by 30 · see citing works
Riccio, B. V. F., Spósito, L., Carvalho, G. C., Ferrari, P. C., & Chorilli, M. (2020) · Archiv der Pharmazie · doi:10.1002/ardp.202000146 · Cited by 30 · see citing works
Ruskovska, T., Budić-Leto, I., Corral‐Jara, K. F., Ajdžanović, V. Z., Arola‐Arnal, A., Bravo, F. I., Deligiannidou, G.-E., Havlík, J., Janeva, M., Kistanova, E. K., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101649 · Cited by 27 · see citing works
Svensson, K., Schnyder, S., Albert, V., Cardel, B., Quagliata, L., Terracciano, L., & Handschin, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.590653 · Cited by 26 · see citing works
Jakubek, P., Pakula, B., Rossmeisl, M., Pinton, P., Rimessi, A., & Wieckowski, M. R. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-024-03700-w · Cited by 25 · see citing works
Caldarelli, I., Speranza, M. C., Bencivenga, D., Tramontano, A., Borgia, A., Pirozzi, A. V. A., Perrotta, S., Oliva, A., Ragione, F. D., & Borriello, A. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.12.011 · Cited by 25 · see citing works
The Role of Dietary Phytoestrogens and the Nuclear Receptor PPARγ in Adipogenesis: An in Vitro Study
Hall, J. M., Powell, H. R., Rajic, L., & Korach, K. S. (2019) · Environmental Health Perspectives · doi:10.1289/ehp3444 · Cited by 25 · see citing works
Abdollahi, S., Vajdi, M., Meshkini, F., Vasmehjani, A. A., Sangsefidi, Z. S., Clark, C. C. T., & Soltani, S. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.03.002 · Cited by 24 · see citing works
Carpéné, C., Gómez‐Zorita, S., Gupta, R., Grès, S., Rancoule, C., Cadoudal, T., Mercader, J., Gomez, A., Bertrand, C., & Iffiú-Soltész, Z. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0668-1 · Cited by 24 · see citing works
Murugan, D. D., Balan, D., & Wong, P. (2021) · Phytotherapy Research · doi:10.1002/ptr.7205 · Cited by 24 · see citing works
Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance
Quiñones, M., Martínez-Grobas, E., Fernø, J., Pérez-Lois, R., Seoane, L. M., & Al–Massadi, O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031430 · Cited by 22 · see citing works
Poltronieri, P., Xu, B., & Giovinazzo, G. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200705220722 · Cited by 21 · see citing works
Prevention of obesity by dietary resveratrol: how strong is the evidence?
Wang, S., Zhu, M. J., & Du, . (2015) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2015.1096771 · Cited by 20 · see citing works
Calderón-DuPont, D., Torre-Villalvazo, I., & Díaz‐Villaseñor, A. (2022) · Biochimie · doi:10.1016/j.biochi.2022.08.021 · Cited by 19 · see citing works
Hillsley, A., Chin, V., Li, A., & McLachlan, C. S. (2022) · Nutrients · doi:10.3390/nu14071424 · Cited by 18 · see citing works
The Variable Role of SIRT1 in the Maintenance and Differentiation of Mesenchymal Stem Cells
Zainabadi, K. (2018) · Regenerative Medicine · doi:10.2217/rme-2017-0128 · Cited by 17 · see citing works
Resveratrol inhibits white adipose deposition by the ESR1-mediated PI3K/AKT signaling pathway
Yang, B. J., Wang, Q., Li, Y., Zhang, S., Sun, Y., Wei, Y., Jiang, Q., & Huang, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111448 · Cited by 15 · see citing works
The emerging global phenomenon of sarcopenic obesity: Role of functional foods; a conference report
Shao, A. E., Campbell, W. W., Chen, C. O., Mittendorfer, B., Rivas, D. A., & Griffiths, J. C. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.048 · Cited by 15 · see citing works
Resveratrol-Induced Effects on Body Fat Differ Depending on Feeding Conditions
Milton‐Laskibar, I., Gómez‐Zorita, S., Aguirre, L., Fernández‐Quintela, A., González, M. A., & Portillo, M. P. (2017) · Molecules · doi:10.3390/molecules22122091 · Cited by 14 · see citing works
Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials
Mendes, I., Ribeiro, M. G. C., de Souza, L. F., Rosa, C. D. O. B., Hermsdorff, H. H. M., & Bressan, J. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00626-3 · Cited by 13 · see citing works
Combinations of bio-active dietary constituents affect human white adipocyte function in-vitro
Warnke, I., Jocken, J. W. E., Schoop, R., Toepfer, C., Góralczyk, R., & Schwager, J. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0143-5 · Cited by 13 · see citing works
Self-citationBednarczyk, M., Szeja, N., Łętowski, D., Waniczek, D., Dzięgielewska-Gęsiak, S., & Muc‐Wierzgoń, M. (2024) · Nutrients · doi:10.3390/nu16234003 · Cited by 13 · see citing works
Rodríguez-López, L. A., Torre-Villalvazo, I., Alemán, G., Flores‐López, A., Guevara‐Cruz, M., Sánchez‐Tapia, M., Torre-Anaya, E. A., Martínez-López, V., Vásquez‐Reyes, S., Torres‐Villalobos, G., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00921-3 · Cited by 12 · see citing works
The Journey of Resveratrol from Vineyards to Clinics
Venkat, R., Verma, E., Daimary, U. D., Kumar, A., Girisa, S., Dutta, U., Ahn, K. S., & Kunnumakkara, A. B. (2022) · Cancer Investigation · doi:10.1080/07357907.2022.2115057 · Cited by 12 · see citing works
Alternative Methods as Tools for Obesity Research: In Vitro and In Silico Approaches
Pamplona, J. H., Zoehler, B., Shigunov, P., Barisón, M. J., Severo, V. R., Erich, N. M., Ribeiro, A. L., Horinouchi, C. D. D. S., Suzukawa, A. A., Robert, A. W., et al. (2022) · Life · doi:10.3390/life13010108 · Cited by 12 · see citing works
Warburton, A., Vasieva, O., Quinn, P., Stewart, J. P., & Quinn, J. P. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003506 · Cited by 12 · see citing works
Sirtuin activation as a therapeutic approach against inborn errors of metabolism
Bleeker, J. C., & Houtkooper, R. H. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9939-8 · Cited by 11 · see citing works
Resveratrol Inhibits Human Visceral Preadipocyte Proliferation and Differentiation <i>in vitro</i>
Sun, W., Yu, S., Han, H., Yuan, Q., Chen, J., & Xu, G. (2019) · Lipids · doi:10.1002/lipd.12196 · Cited by 11 · see citing works
Zhang, S., Cui, Y., Gao, X., Wei, C., Wang, Q., Yang, B. J., Sun, W., Luo, Y., Jiang, Q., & Huang, Y. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109351 · Cited by 11 · see citing works
Nutrigenomic Information in the openEHR Data Set
Maranhao, P. A., Bacelar-Silva, G. M., Ferreira, D., Calhau, C., Vieira‐Marques, P., & Cruz-Correia, R. J. (2018) · Applied Clinical Informatics · doi:10.1055/s-0038-1635115 · Cited by 10 · see citing works
Zheng, X., Shi, J., Yu, Y.-M., Shen, Y., Tan, B., Ye, X., Li, J., & Feng, J. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00487 · Cited by 9 · see citing works
- Authors
- Konings, E., Timmers, S., Boekschoten, M. V., Goossens, G. H., Jocken, J. W., Afman, L. A., Müller, M., Schrauwen, P., Mariman, E. C., & Blaak, E. E.
- Affiliations
- Maastricht University Medical Centre (NL)
- TiFN (NL)
- Corresponding author
- Blaak, E E
- ORCID
- Venue
- International Journal of Obesity
- Published
- 2013-08-20
- Volume
- 38
- Issue
- 3
- Pages
- 470-473
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2113139949
- Semantic Scholar
- 30a0401887408462b85ba740af8254f40ebfe638
- Cited by
- 143
- References
- 21
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 6
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- resveratrol, obesity, adipose tissue, adipocyte size, adipose tissue morphology, gene expression, Wnt signaling, Notch signaling, adipogenesis, autophagy, lysosomal pathway, TFEB, polyphenols, subcutaneous adipose tissue
- MeSH terms
- Resveratrol, Adipose Tissue, Adult, Aged, Double-Blind Method, Enzyme Inhibitors, Humans, Male, Middle Aged, Obesity, Stilbenes, Signal Transduction, Treatment Outcome, Adipocytes, Cross-Over Studies, Gene Expression Profiling, Adipogenesis, Receptors, Notch, Wnt Signaling Pathway
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