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Effect of 2-y n−3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial
Open accessAbstract
Background Increased consumption of n-3 (omega-3) long-chain polyunsaturated fatty acids (LC PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may maintain cognitive function in later life.Objective We tested the hypothesis that n-3 LC PUFA supplementation would benefit cognitive function in cognitively healthy older people.Design At total of 867 cognitively healthy adults, aged 70-79 y, from 20 general practices in England and Wales were randomly assigned into a double-blind controlled trial of daily capsules providing 200 mg EPA plus 500 mg DHA or olive oil for 24 mo. Treatment-allocation codes were obtained from a central computerized randomization service. Trained research nurses administered a battery of cognitive tests, including the primary outcome, the California Verbal Learning Test (CVLT), at baseline and 24 mo. Intention-to-treat analysis of covariance, with adjustment for baseline cognitive scores, age, sex, and age at leaving full-time education, included 748 (86%) individuals who completed the study.Results The mean age of participants was 75 y; 55% of the participants were men. Withdrawals and deaths were similar in active (n = 49 and n = 9, respectively) and placebo (n = 53 and n = 8, respectively) arms. Mean (+/-SD) serum EPA and DHA concentrations were significantly higher in the active arm than in the placebo arm at 24 mo (49.9 +/- 2.7 mg EPA/L in the active arm compared with 39.1 +/- 3.1 mg EPA/L in the placebo arm; 95.6 +/- 3.1 mg DHA/L in the active arm compared with 70.7 +/- 2.9 mg DHA/L in the placebo arm). There was no change in cognitive function scores over 24 mo, and intention-to-treat analysis showed no significant differences between trial arms at 24 mo in the CVLT or any secondary cognitive outcome.Conclusions Cognitive function did not decline in either study arm over 24 mo. The lack of decline in the control arm and the relatively short intervention period may have limited our ability to detect any potential beneficial effect of fish oil on cognitive function in this study. The Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) Study was registered at www.controlled-trials.com as ISRCTN 72331636.
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“In a trial in the United Kingdom, 748 cognitively healthy adults aged 70–79 years received either 500 mg DHA and 200 mg EPA or a placebo daily for 24 months [83]. Cognitive function did not differ significantly between the 2 groups, although cognitive function did not decline in either group.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [83]
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,368
Self-citationGlobal prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336
Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707
The Validity of Two Versions of the GHQ in the WHO Study of Mental Illness in General Health Care
GOLDBERG, D. P., GATER, R., SARTORIUS, N., USTUN, T. B., PICCINELLI, M., GUREJE, O., & RUTTER, C. (1997) · Psychological Medicine · doi:10.1017/s0033291796004242 · Cited by 3,657
Direct transesterification of all classes of lipids in a one-step reaction.
Lepage, G., & ROY, C. C. (1986) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38861-1 · Cited by 2,385
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135
Nass, R. D. (1984) · Annals of Neurology · doi:10.1002/ana.410160524 · Cited by 1,081
Determining Clinically Important Differences in Health Status Measures
Samsa, G., Edelman, D. E., Rothman, M. L., Williams, G. R., Lipscomb, J., & Matchar, D. B. (1999) · PharmacoEconomics · doi:10.2165/00019053-199915020-00003 · Cited by 917
Neuringer, M. D., CONNOR, W. E., Lin, D. S., Barstad, L., & Luck, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4021 · Cited by 914
Durga, J., van Boxtel, M. P., Schouten, E. G., Kok, F. J., Jolles, J., Katan, M. B., & Verhoef, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60109-3 · Cited by 758
Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia
Féart, C. (2009) · JAMA · doi:10.1001/jama.2009.1146 · Cited by 757
Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751
Distribution and fatty acid composition of phosphoglycerides in normal human brain
Svennerholm, L. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42702-6 · Cited by 642
Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
Kalmijn, S., van Boxtel, M. P. J., Ocké, M., Verschuren, W. M. M., Kromhout, D., & Launer, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000103860.75218.a5 · Cited by 524
Fish, meat, and risk of dementia: cohort study
Barberger‐Gateau, P. (2002) · BMJ · doi:10.1136/bmj.325.7370.932 · Cited by 486
Dietary factors and Alzheimer's disease
Luchsinger, J. A., & Mayeux, R. P. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00878-6 · Cited by 442
Fish Consumption and Cognitive Decline With Age in a Large Community Study
Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.noc50161 · Cited by 428
Nutrition in Brain Development and Aging: Role of Essential Fatty Acids
Uauy, R. D., & Dangour, A. D. (2006) · Nutrition Reviews · doi:10.1301/nr.2006.may.s24-s33 · Cited by 426
Self-citationA Controlled Trial of Homocysteine Lowering and Cognitive Performance
McMahon, J. A., Green, T., Skeaff, C. M., Knight, R. G., Mann, J. I., & Williams, S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054025 · Cited by 395
Self-citationEffect of fish oil on cognitive performance in older subjects
van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Dullemeijer, C., Olde-Rikkert, M. G. M., Beekman, A. T. F., & de Groot, C. P. G. M. (2008) · Neurology · doi:10.1212/01.wnl.0000324268.45138.86 · Cited by 390
Benefits of fatty fish on dementia risk are stronger for those without APOE ε4
Huang, T. L., Zandi, P. P., Tucker, K. L., Fitzpatrick, A. L., Kuller, L. H., Fried, L. P., Burke, G. L., & Carlson, M. C. (2005) · Neurology · doi:10.1212/01.wnl.0000183148.34197.2e · Cited by 384
Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353
Dietary intake and cognitive function in a group of elderly people
Ortega, R., Requejo, A. M., Andrés, P., López-Sobaler, A. M., Quintas, M. E., Redondo, M. R., Navia, B., & Rivas, T. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.803 · Cited by 350
California Verbal Learning Test--Second Edition
Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1987) · PsycTESTS Dataset · doi:10.1037/t15072-000 · Cited by 347
van Gelder, B. M., Tijhuis, M., Kalmijn, S., & Kromhout, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1142 · Cited by 346
The Personal Social Services Research Unit
Hallam, A., Darton, R. A., McIntosh, E., & Netten, A. (1994) · Kent Academic Repository (University of Kent) · Cited by 342
Diet and risk of dementia: Does fat matter?: The Rotterdam Study
Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., van Swieten, J. C., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B. (2002) · Neurology · doi:10.1212/01.wnl.0000038345.77753.46 · Cited by 324
IANA task force on nutrition and cognitive decline with aging.
Guyonnet, S., van Kan, G. A., Andrieu, S., Barberger‐Gateau, P., Berr, C., Bonnefoy, M., Dartigues, J. F., de Groot, C. P. G. M., Ferry, M., Galan, P., et al. (2007) · PubMed · Cited by 276
Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk
Devore, E. E., Grodstein, F., van Rooij, F. J., Hofman, A., Rosner, B., Stampfer, M. J., Witteman, J. C., & Breteler, M. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27037 · Cited by 205
Demographically Corrected Norms for the California Verbal Learning Test
Norman, M. A., Evans, J. D., Miller, W. S., & Heaton, R. K. (2000) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/1380-3395(200002)22:1;1-8;ft080 · Cited by 179
Endpoints for trials in Alzheimer's disease: a European task force consensus
Vellas, B. J., Andrieu, S., Sampaio, C., Coley, N., & Wilcock, G. K. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70087-5 · Cited by 152
Hennekens, C. H. (2009) · JAMA · doi:10.1001/jama.2009.1756 · Cited by 149
Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
Kröger, E., Verreault, R., Carmichael, P.-H., Lindsay, J., Julien, P., Dewailly, É., Ayotte, P., & Laurin, D. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26987 · Cited by 149
Omega-3 fatty acids and risk of cognitive impairment and dementia
Laurin, D., Verreault, R., Lindsay, J., Dewailly, É., & Holub, B. J. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2003-5407 · Cited by 147
The health and lifestyle survey : seven years on
Cox, B. D., Huppert, F. A., & Whichelow, M. J. (1993) · Dartmouth eBooks · Cited by 145
Omega 3 fatty acid for the prevention of dementia
Lim, W. S., Gammack, J. K., van Niekerk, J. K., & Dangour, A. D. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005379.pub2 · Cited by 139
Self-citationAging and forgetting in prospective and retrospective memory tasks.
Maylor, E. A. (1993) · Psychology and Aging · doi:10.1037/0882-7974.8.3.420 · Cited by 119
Guyonnet, S., Andrieu, S., DANTOINE, T. F., Dartigues, J., Touchon, J., Vellas, B. J., & MAPT Study Group (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.008 · Cited by 112
Lifetime cognitive function and timing of the natural menopause
Richards, M., Kuh, D. J., Hardy, R., & Wadsworth, M. E. J. (1999) · Neurology · doi:10.1212/wnl.53.2.308 · Cited by 111
Self-citationDangour, A. D., Allen, E., Elbourne, D. R., FLETCHER, A. E., Richards, M., & Uauy, R. D. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0057-2 · Cited by 92
Self-citationAlbanese, E., Dangour, A. D., Uauy, R., Acosta, D., Guerra, M., Guerra, S. S. G., Huang, Y., Jacob, K., Llibre de Rodriguez, J., Noriega, L. H., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27580 · Cited by 89
Self-citationTierney, M. C., OH, P. I., Moineddin, R., Greenblatt, E. M., Snow, W. G., Fisher, R. H., Iazzetta, J., George‐Hyslop, P. S., & MacLusky, N. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.02.009 · Cited by 73
Connor, S. L., Zhu, N., Anderson, G. J., Hamill, D., Jaffe, E. S., Carlson, J., & Connor, W. E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.1.21 · Cited by 62
Dangour, A. D., Clemens, F., Elbourne, D. R., Fasey, N., FLETCHER, A. E., Hardy, P., Holder, G. E., Huppert, F. A., Knight, R., Letley, L. H., et al. (2006) · Nutrition Journal · doi:10.1186/1475-2891-5-20 · Cited by 49
Self-citationHoffman, D. R., Birch, E. E., Birch, D. G., & Uauy, R. D. (1999) · Lipids · doi:10.1007/s11745-999-0371-y · Cited by 46
Self-citationTHE FATTY ACID COMPOSITION OF HUMAN RETINAL VITAMIN A ESTER AND THE LIPIDS OF HUMAN RETINAL TISSUE.
Futterman, S., & Js, A. (1964) · PubMed · Cited by 23
van Niekerk, J. K., Nielsen, T. A., Pasu, S., Shore, S., & Huppert, F. A. (2004) · Aging Neuropsychology and Cognition · doi:10.1080/13825580490521377 · Cited by 9
Flagged first, then by citations
2 of the 50 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Goldberg D. The detection of psychiatric illness by questionnaire. London, United Kingdom: Oxford University Press, 1972.
Cited by
Sorted by citations
Omega-3 polyunsaturated fatty acids and their health benefits
Shahidi, F., & Ambigaipalan, P. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111317-095850 · Cited by 1,390
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173
Andrieu, S., Guyonnet, S., Coley, N., Cantet, C., Bonnefoy, M., Bordes, S., Bories, L., Cufi, M.-N., Dantoine, T., Dartigues, J.-F., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30040-6 · Cited by 838
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Brown, T. J., Brainard, J. S., Biswas, P., Thorpe, G., Moore, H. J., Deane, K. H., AlAbdulghafoor, F. K., Summerbell, C., Worthington, H. V., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003177.pub3 · Cited by 647
Metadata
- Authors
- Dangour, A. D., Allen, E., Elbourne, D., Fasey, N., Fletcher, A. E., Hardy, P., Holder, G. E., Knight, R., Letley, L., Richards, M., & Uauy, R.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- ORCID
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 91
- Issue
- 6
- Pages
- 1725-1732
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2168895330
- Cited by
- 296
- References
- 50
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 4 · 2023: 11 · 2022: 12 · 2021: 15 · 2020: 26 · 2019: 18 · 2018: 23 · 2017: 14 · 2016: 21 · 2015: 35 · 2014: 19 · 2013: 22 · 2012: 23
- FWCI
- 24.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- acids, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, cognitive function, older adults, cognitive decline, verbal learning, olive oil placebo, cognitive aging, recall and recognition, attention and processing speed, executive function, visuospatial ability, psychomotor speed
- MeSH terms
- Aged, Cognition, Double-Blind Method, Female, Humans, Male, Neuropsychological Tests, Patient Compliance, Fatty Acids, Omega-3, Dietary Supplements
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