Cited by 578Coffee research and impactsPhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans

Open access

Farah, Adriana, Monteiro, Mariana, Donangelo, Carmen M., Lafay, Sophie·2008·The Journal of Nutrition

DOI 10.3945/jn.108.095554

Open this paper in CoChat — free account Open PDF

Abstract

Chlorogenic acids (CGA) are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main CGA found in nature. Because green coffee is a major source of CGA, it has been used for production of nutraceuticals. However, data on the bioavailability of CGA from green coffee in humans are inexistent. The present study evaluated the pharmacokinetic profile and apparent bioavailability of CGA in plasma and urine of 10 healthy adults for 8 h after the consumption of a decaffeinated green coffee extract containing 170 mg of CGA. Three CQA, 3 diCQA, and caffeic, ferulic, isoferulic, and p-coumaric acids were identified in plasma by HPLC-Diode Array Detector-MS after treatment. Over 30% (33.1 +/- 23.1%) of the ingested cinnamic acid moieties were recovered in plasma, including metabolites, with peak levels from 0.5 to 8 h after treatment. CGA and metabolites identified in urine after treatment were 4-CQA, 5-CQA, and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids, totaling 5.5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3945/jn.108.095554

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Phenolic compounds in coffee
Farah, A., & Donangelo, C. M. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100003 · Cited by 874
Self-citation
Effect of Roasting on the Formation of Chlorogenic Acid Lactones in Coffee
Farah, A., de Paulis, T., Trugo, L. C., & Martin, P. R. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048701t · Cited by 540
Self-citation
Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of the Natural Polyphenol Chlorogenic Acid
dos Santos, M. D., Almeida, M. C., Lopes, N. P., & de Souza, G. E. P. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2236 · Cited by 513
The Physiology and Pathophysiology of Gastric Emptying in Humans
Minami, H., & McCallum, R. W. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80178-x · Cited by 511
Chlorogenic Acid, Quercetin-3-Rutinoside and Black Tea Phenols Are Extensively Metabolized in Humans
Olthof, M. R., Hollman, P. C. H., Buijsman, M. N. C. P., van Amelsvoort, J. M. M., & Katan, M. B. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.6.1806 · Cited by 468
Coffee consumption and risk for type 2 diabetes mellitus
Salazar-Martinez, E., Willett, W. C., Ascherio, A., Manson, J. E., Leitzmann, M. F., Stampfer, M. J., & Hu, F. B. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-1-200401060-00005 · Cited by 462

Show all 50 references

Research works printed but not linked: 3

Blum, 2007, Effect of a green decaffeinated coffee extract on glycaemia, NutraFoods Res., 6, 13
Farah, 2006, Chlorogenic acid isomers from coffee are differentially uptaken by HEPG2 human hepatocite cell line., Proceedings of the 21st International Conference on Coffee Science, 101
1976, Nomenclature of cyclitols, Biochem J., 153, 23

Sorted by citations

Items 301–400 of 576

Harvest maturity stage affects the concentrations of health-promoting compounds: Lupeol, mangiferin and phenolic acids in the pulp and peel of ripe ‘Kensington Pride’ mango fruit
Vithana, M. D. K., Singh, Z., & Johnson, S. K. (2018) · Scientia Horticulturae · doi:10.1016/j.scienta.2018.08.019 · Cited by 20
A lightly roasted coffee extract improves blood and tissue redox status in rats through enhancement of GSH biosynthesis
Priftis, A., Soursou, V., Makiou, A.-S., Tekos, F., Veskoukis, A. S., Tsantarliotou, M. P., Taitzoglou, I., & Kouretas, D. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.01.012 · Cited by 21
Effect of simultaneous consumption of soymilk and coffee on the urinary excretion of isoflavones, chlorogenic acids and metabolites in healthy adults
Felberg, I., Farah, A., Monteiro, M. C., Godoy, R. L. D. O., Pacheco, S., Calado, V. M. D. A., & Donangelo, C. M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.059 · Cited by 20
Self-citation
The effect of green coffee extract supplementation on blood pressure: A systematic review and meta‐analysis of randomized controlled trials
Han, B., Nazary-Vannani, A., Talaei, S., Clark, C. C. T., Rahmani, J., Rasekhmagham, R., & Kord‐Varkaneh, H. (2019) · Phytotherapy Research · doi:10.1002/ptr.6481 · Cited by 20
Male date palm flowers: Valuable nutritional food ingredients and alternative antioxidant source and antimicrobial agent
Karra, S., Sebii, H., Jardak, M., Bouaziz, M. A., Attia, H., Blecker, C. S., & Besbes, S. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.02.010 · Cited by 20
Targeted and Untargeted Mass Spectrometry-Based Metabolomics for Chemical Profiling of Three Coffee Species
Montis, A., Souard, F., Delporte, C., Stoffelen, P., Stévigny, C., & Antwerpen, P. V. (2022) · Molecules · doi:10.3390/molecules27103152 · Cited by 19
“Products with high content of chlorogenic acids from green coffee beans have been successfully marketed [8].”
Background
Coffee and Parkinson's disease
Asuku, A. O., Ayinla, M. T., Olajide, T. S., Oyerinde, T. O., Yusuf, J. A., Bayo-Olugbami, A. A., & Fajemidagba, G. A. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.001 · Cited by 19
Neuroprotective Effect of Chlorogenic Acids against Alzheimer’s Disease
Anggreani, E., & Lee, C. Y. (2017) · International Journal of Food Science Nutrition and Dietetics · doi:10.19070/2326-3350-1700059 · Cited by 20
“preferential absorption of several compounds such as 5-CQA compared to 4-CQA, suggested that 4-CQA was metabolized/ uptake faster by organs, such as liver and adipose tissue [13].”
BackgroundInfluential
Contribution of Individual Polyphenols to Antioxidant Activity of Cotoneaster bullatus and Cotoneaster zabelii Leaves—Structural Relationships, Synergy Effects and Application for Quality Control
Kicel, A., Owczarek, A., Kapusta, P., Kołodziejczyk-Czepas, J., & Olszewska, M. A. (2020) · Antioxidants · doi:10.3390/antiox9010069 · Cited by 19
Biological Actions and Molecular Mechanisms of Sambucus nigra L. in Neurodegeneration: A Cell Culture Approach
Palomino, O. M., García-Aguilar, A., González, A., Guillén, C., Benito, M., & Goya, L. (2021) · Molecules · doi:10.3390/molecules26164829 · Cited by 20
Coffee
(2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015028 · Cited by 19
The Effect of Green Coffee Bean Extract Supplementation on Body Fat Reduction in Overweight/Obese Women
Park, J. Y., Kim, J. Y., Lee, S. P., & Lee, J. H. (2010) · Journal of Nutrition and Health · doi:10.4163/kjn.2010.43.4.374 · Cited by 19
Acyl quinic acid derivatives from the stems of Erycibe obtusifolia
Liu, Z., Feng, Z., Yang, Y., Jiang, J., & Zhang, P. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.09.012 · Cited by 19
Identification and Quantification of Key Phytochemicals, Phytohormones, and Antioxidant Properties in Coccinia grandis during Fruit Ripening
Lee, I. Y., & Joo, N. (2022) · Antioxidants · doi:10.3390/antiox11112218 · Cited by 18
“Results of in vivo and in vitro experiments show that chlorogenic acid mostly has important antioxidant and anticarcinogenic activities [29].”
Background
Evaluation of antioxidant activity, total phenolics and phytochemical content of selected varieties of karonda fruits (Carissa carandas)
Azeez, S., Karunakaran, G., Tripathi, P. C., Shivashankara, K. S., & Roy, T. (2016) · The Indian Journal of Agricultural Sciences · doi:10.56093/ijas.v86i6.58994 · Cited by 18
“…specific uses in food and medicine, as for vanillic acid (FAO/WHO Expert Committee on Food Additives, JECFA no. 959; Sinha et al. 2008), protocatechuic acid (Kakkar and Bais 2014), tcinnamic acid and its derivatives including chlorogenic acids and salicylic acid (Sharma 2011, Farah et al. 2008).”
Background
Comparison of plasma pharmacokinetics of Tanreqing solution between intratracheal aerosolization and intravenous injection in rats
Cui, L., Liu, S., Luo, G., Wang, G., Zhang, B., & Nie, Q.-X. (2017) · Biomedical Chromatography · doi:10.1002/bmc.4116 · Cited by 18
Phytochemical Composition of Solanum retroflexum Analysed with the Aid of Ultra-Performance Liquid Chromatography Hyphenated to Quadrupole-Time-of-Flight Mass Spectrometry (UPLC-qTOF-MS)
Daji, G. A., Steenkamp, P. A., Madala, N., & Dlamini, B. C. (2018) · Journal of Food Quality · doi:10.1155/2018/3678795 · Cited by 18
The Effect of Standardised Flower Extracts of Sorbus aucuparia L. on Proinflammatory Enzymes, Multiple Oxidants, and Oxidative/Nitrative Damage of Human Plasma Components In Vitro
Olszewska, M. A., Kołodziejczyk-Czepas, J., Rutkowska, M., Magiera, A., Michel, P., Rejman, M. W., Nowak, P., & Owczarek, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9746358 · Cited by 18
Correlation Phenolic Concentration to Antioxidant and Antibacterial Activities of Several Ethanolic extracts from Indonesia
Sartini, S., Djide, M. N., & Nainu, F. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1341/7/072009 · Cited by 20
“18 23–36 [15] Farah A, Monteiro M, Donangelo C M and Lafay S 2008 Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans J.”
Background
Coffee industrial waste as a natural source of bioactive compounds with antibacterial and antifungal activities
Silva, C., Gabriel, C., Cerqueira, F., Manso, M. C., & Vinha, A. F. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 18
Inhibition of radical-induced DNA strand breaks by water-soluble constituents of coffee: phenolics and caffeine metabolites
Rathod, M. A., Patel, D. K., Das, A., Tipparaju, S. R., Shinde, S. S., & Anderson, R. F. (2013) · Free Radical Research · doi:10.3109/10715762.2013.788167 · Cited by 20
Breakfast consumption induces retarded release of chlorogenic acid metabolites in humans
Scherbl, D., Renouf, M., Marmet, C., Poquet, L., Cristiani, I., Dahbane, S., Emady‐Azar, S., Sauser, J., Galan, J., Dionisi, F., et al. (2016) · European Food Research and Technology · doi:10.1007/s00217-016-2793-y · Cited by 18
“[15] detected 30% hydroxycinnamic acids in plasma after consumption of encapsulated green coffee.”
Background
Coffee, type 2 diabetes and pancreatic islet function – A mini-review
Costabile, A., Sarnsamak, K., & Hauge-Evans, A. C. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.04.011 · Cited by 18
Identification of bioactivity markers of Sorbus domestica leaves in chromatographic, spectroscopic and biological capacity tests: Application for the quality control
Rutkowska, M., Owczarek, A., Kołodziejczyk-Czepas, J., Michel, P., Piotrowska, D. G., Kapusta, P., Nowak, P., & Olszewska, M. A. (2019) · Phytochemistry Letters · doi:10.1016/j.phytol.2019.02.004 · Cited by 18
Identifying anti-HSV compounds from unrelated plants using NMR and LC–MS metabolomic analysis
Prinsloo, G., & Vervoort, J. J. M. (2018) · Metabolomics · doi:10.1007/s11306-018-1432-y · Cited by 17
Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development in zebrafish (Danio rerio) through the Wnt signaling pathway
Liu, Y., Guo, J., Zhang, J., Deng, Y., Xiong, G., Fu, J., Wei, L., & Lu, H. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.106039 · Cited by 17
Determination of caffeoylquinic acids in feed and related products by focused ultrasound solid–liquid extraction and ultra-high performance liquid chromatography–mass spectrometry
Tena, M. T., Martínez, M. P. S., & Cardozo, P. W. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.04.049 · Cited by 17
Polyphenol-Rich Extracts from Cotoneaster Leaves Inhibit Pro-Inflammatory Enzymes and Protect Human Plasma Components against Oxidative Stress In Vitro
Kicel, A., Kołodziejczyk-Czepas, J., Owczarek, A., Marchelak, A., Sopinska, M., Ciszewski, P., Nowak, P., & Olszewska, M. A. (2018) · Molecules · doi:10.3390/molecules23102472 · Cited by 17
“1 μg/mL (depending on the isomer) was determined after ingestion of green coffee extract with the total dose of all isomers about 100 mg [28].”
Improvement of physico‐chemical properties and phenolic compounds bioavailability by concentrating dietary fiber of peach ( Prunus persica ) juice by‐product
Rodríguez‐González, S., Pérez‐Ramírez, I. F., Castaño‐Tostado, E., Amaya‐Llano, S. L., Rodríguez-García, M. E., & Reynoso‐Camacho, R. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8812 · Cited by 17
Coffea arabica extracts and their chemical constituents in a murine model of gouty arthritis: How they modulate pain and inflammation
Matosinhos, R. C., Bezerra, J. P., Barros, C. H., Bernardes, A. C. F. P. F., Coelho, G. B., Araújo, M. C. D. P. M., Aguiar‐Soares, R. D. D. O., Sachs, D., & Saúde-Guimarães, D. A. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114778 · Cited by 17
Potential Health Implication of in Vitro Human Low-Density Lipoprotein–Vitamin E Oxidation Modulation by Polyphenols Derived from Côte d’Ivoire’s Oil Palm Species
Monde, A., Carbonneau, M., Michel, F., Lauret, C., Diabaté, S., Konan, E. K., Sess, D., & Cristol, J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201658g · Cited by 17
Ectopic expression of the Osmyb4 rice gene enhances synthesis of hydroxycinnamic acid derivatives in tobacco and clary sage
Docimo, T., Mattana, M., Fasano, R., Consonni, R., Tommasi, N. D., Coraggio, I., & Leone, A. (2012) · Biologia Plantarum · doi:10.1007/s10535-012-0257-1 · Cited by 17
“The increased content of CGA, which is also present in different plant products such as apples, pears, tomatoes, potatoes, eggplants and coffee (Farah et al. 2008), is associated with an increase in tolerance to oxidative stress and resistance to fungal pathogens and RA participates in plant defence system against fun…”
Background
Bioavailability and antioxidant effect of the Ilex Paraguariensis polyphenols
Boado, L. S., Fretes, R. M., & Brumovsky, L. A. (2015) · Nutrition & Food Science · doi:10.1108/nfs-08-2014-0079 · Cited by 16
Effect of Green Coffee Bean Extract on the Lipid Oxidative Stability and Storage Quality of Restructured Mutton Blocks Containing Colocasia esculenta, a Novel Binding Agent
Dilnawaz, H. M., Kumar, S., & Bhat, Z. F. (2017) · Agricultural Research · doi:10.1007/s40003-017-0283-5 · Cited by 16
“Studies have demonstrated that consumption of green coffee extract produces antihypertensive effect, improvement in vasoreactivity, inhibitory effect on fat accumulation and body weight, and modulation of glucose metabolism [22].”
Background
In vitro cytotoxicity, antibacterial activity and HSA and ct-DNA interaction studies of chlorogenic acid loaded on γ-Fe 2 O 3 @SiO 2 as new nanoparticles
Shahabadi, N., Akbari, A., Karampour, F., Falsafi, M., & Zendehcheshm, S. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2030799 · Cited by 16
“Green (or raw) coffee is a main natural resource of CGA (Farah et al., 2008; Mills et al., 2015).”
Background
New Approaches and Advancements in Drug Development from Phenolic P-coumaric Acid
Malik, N., & Dhiman, P. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/0929866529666220426121324 · Cited by 16
Acer truncatum leaves reduce lipid accumulation and improve liver and intestine health of grass carp (Ctenopharyngodon idella) fed with high-fat diet
Ye, L., Zhang, X., Wang, C., Liu, S., Li, P., Zhang, C., Gao, Q., Ji, H., & Yu, H. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739613 · Cited by 16
Advancements in Coffee Manufacturing: From Dehydration Techniques to Quality Control
Al‐Ghamdi, S., Alfaifi, B., Elamin, W. M., & Lateef, M. A. (2024) · Food Engineering Reviews · doi:10.1007/s12393-024-09383-5 · Cited by 16
High phenolics Rutgers Scarlet Lettuce improves glucose metabolism in high fat diet‐induced obese mice
Cheng, D. M., Roopchand, D. E., Poulev, A., Kuhn, P. E., Armas, I., Johnson, W. D., Oren, A., Ribnicky, D., Zelzion, E., Bhattacharya, D., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600290 · Cited by 16
“Chlorogenic acid was reportedly absorbed in the stomach and small intestine of rats with intact compound detectable in urine and plasma [15]; however, conflicting data have been reported regarding detection of intact chlorogenic in plasma in human studies [16,17].”
Background
A mix of chlorogenic and caffeic acid reduces C/EBPß and PPAR-γ1 levels and counteracts lipid accumulation in macrophages
Marino, M., Bo’, C. D., Tucci, M., Venturi, S., Mantegazza, G., Taverniti, V., Möller, P., Riso, P., & Porrini, M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02714-w · Cited by 16
HPLC-ED Analysis of Phenolic Compounds in Three Bosnian Crataegus Species
Čulum, D., Čopra-Janičijević, A., Vidić, D., Klepo, L., Tahirović, A., Bašić, N., & Maksimović, M. (2018) · Foods · doi:10.3390/foods7050066 · Cited by 16
“It has been reported that chlorogenic acid shows antioxidant, anti-inflammatory, and neuroprotective properties [23].”
Background
Analysis of Chlorogenic Acids and Other Hydroxycinnamates in Food, Plants, and Pharmacokinetic Studies
Kuhnert, N., Karaköse, H., & Jaiswal, R. (2012) · CRC Press eBooks · doi:10.1201/b11653-26 · Cited by 16
Transformation of carrots into novel food ingredients and innovative healthy foods
Jacobo‐Velázquez, D. A. (2023) · Applied Food Research · doi:10.1016/j.afres.2023.100303 · Cited by 19
Chlorogenic acid as an indispensible partner of caffeic acid in coffee via selective regulation of prooxidative actions of caffeic acid
Li, X., Yang, L., Hao, M., Song, T., He, Y., Yang, M., & Zhang, J. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113482 · Cited by 15
Green Coffee Bean
Garg, S. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00047-4 · Cited by 17
A mystery of a cup of coffee; an insight look by chemist
Karpińska, J., Świsłocka, R., & Lewandowski, W. (2017) · BioFactors · doi:10.1002/biof.1371 · Cited by 15
“It undergoes enzymatic methylation, decarboxylation, dehydroxylation, hydrogenation, and boxidation [15,20,21].”
Background
Comparative effect of coffee robusta and coffee arabica (Qahwa) on memory and attention
Alharbi, W. D. M., Azmat, A., & Ahmed, M. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0230-6 · Cited by 19
Organic anion transporter 3 (OAT3)-mediated transport of dicaffeoylquinic acids and prediction of potential drug-drug interaction
Wang, Y., Ren, J., Sun, Q., Zhang, Z., Lin, Y., Deng, S., Wang, C., Huo, X., Sun, C., Tian, X., et al. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.03.022 · Cited by 16
Effects of combined florfenicol and chlorogenic acid to treat acute hepatopancreatic necrosis disease in Litopenaeus vannamei caused by Vibrio parahaemolyticus
Zhai, Q., Chang, Z., Li, J., & Li, J. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737462 · Cited by 13
Sustained Consumption of a Decaffeinated Green Coffee Nutraceutical Has Limited Effects on Phenolic Metabolism and Bioavailability in Overweight/Obese Subjects
Seguido, M. Á., Tarradas, R. M., González-Rámila, S., García-Cordero, J., Sarriá, B., Bravo, L., & Mateos, R. (2022) · Nutrients · doi:10.3390/nu14122445 · Cited by 14
“3% at the end of the 8-week intervention, with percentages in line with values reported by other authors after coffee consumption [13,22,23].”
Result
The roasting process does not influence the extent of conjugation of coffee chlorogenic and phenolic acids
Sanchez‐Bridge, B., Renouf, M., Sauser, J., Beaumont, M., & Actis‐Goretta, L. (2016) · BioFactors · doi:10.1002/biof.1268 · Cited by 15
“A number of studies have examined this question using pure soluble coffees [23,26,31,32] and green coffee extract [33] but have not compared the bioavailability and metabolites of these compounds from different coffee preparations.”
Background
Metabolic fingerprinting of different populations of Phyllanthus niruri L. from Punjab using electrospray ionization mass spectrometry (ESI–MS)
Kaur, B., & Kaur, N. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1674-z · Cited by 14
“Chlorogenic acids (CGAs) are cinnamic acid derivatives formed by esterification of acids such as caffeic, ferulic, and p-coumaric acids with -(-) quinic acid (Farah et al., 2008).”
Background
Effect of Green Coffee Bean Extract Consumption on Blood Pressure and Anthropometric Measures in Healthy Volunteers : A Pilot Crossover Placebo Controlled Study
Al‐Dujaili, E. A. S., Hajleh, M. N. A., & Al-Turk, W. A. (2016) · Jordan Journal of Pharmaceutical Sciences · doi:10.12816/0033383 · Cited by 14
Phytochemicals in Coffee and the Bioavailability of Chlorogenic Acids
Stalmach, A., Clifford, M. N., Williamson, G., & Crozier, A. (2011) · Wiley eBooks · doi:10.1002/9781444347098.ch5 · Cited by 14
A comparative assessment of biological activities of Gundelia dersim Miller and Gundelia glabra Vitek, Yüce & Ergin extracts and their chemical characterization via HPLC-ESI-TOF-MS
Cádiz‐Gurrea, M. D. L. L., Zengin, G., Leyva‐Jiménez, F. J., Fernández‐Ochoa, Á., Sinan, K. I., Çakılcıoğlu, U., Babacan, E. Y., Mahomoodally, M. F., Picot-Allain, M. C. N., Xiao, J., et al. (2020) · Process Biochemistry · doi:10.1016/j.procbio.2020.04.002 · Cited by 13
Pulverization of coffee silverskin extract as a source of antioxidant
Tan, S. P., Kusumocahyo, S. P., & Widiputri, D. I. (2016) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/162/1/012027 · Cited by 13
Effects of thermal process in bioactive compounds of mixed Brazilian cerrado fruit jam
Brandão, T. M., Carvalho, E. E. N., de Lima, J. P., do Carmo, E. L., Elias, H. H. D. S., Martins, G. A. D. S., & Borges, S. V. (2020) · Food Science and Technology · doi:10.1590/fst.28020 · Cited by 13
“Therefore, it can be inferred that the combination of organic acids present in the fruit, citric acid used in the formulation, and processing temperature may have promoted the conversion of compounds derived from cinnamic acid (caffeic acid, trans-cinnamic acid, and trans-3-hydroxy-4methoxycinnamic acid) to m-coumaric…”
Background
In vitro Analysis on Inhibitory Activity of Amylolytic Enzymes in Decaffeinated Green Coffee Bean Extracts and Contributio of Chlorogenic Acids
Kamitani, Y., Iwai, K., Fukunaga, T., KIMURA, R., & Nakagiri, O. (2009) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.56.336 · Cited by 13
Stilbenes and Resveratrol
Bronze, M. R., Duarte, C. M. M., & Matias, A. A. (2012) · CRC Press eBooks · doi:10.1201/b11653-22 · Cited by 13
Influence of exogenous cinnamic acid on the production of chlorogenic acid in Cichorium intybus L cell culture
Shilpa, K., & Lakshmi, B. S. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.01.004 · Cited by 13
Estrogen Receptor-Mediated Transcriptional Activities of Spent Coffee Grounds and Spent Coffee Grounds Compost, and Their Phenolic Acid Constituents
An, B. H., Jeong, H., Kim, J.-H., Park, S., Jeong, J.-H., Kim, J. M., & Chang, M. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02452 · Cited by 13
The Nutraceutical Impact of Polyphenolic Composition in Commonly Consumed Green Tea, Green Coffee and Red Wine Beverages: A Review
Ricci, A., Parpinello, G. P., & Versari, A. (2018) · Recent Advancement in Food Science and Nutrition Research · doi:10.29199/2638-9770/fsnr-101011 · Cited by 12
Sweet potato leaf extract inhibits the simulated in vitro gastrointestinal digestion of native starch
Jeng, T. L., Chiang, Y. C., Lai, C. C., Liao, T. C., Lin, S. Y., Lin, T. C., & Sung, J. M. (2015) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2015.01.002 · Cited by 13
“A commercially available green coffee bean extract (GCBE) recommended to be used for managing the postprandial hyperglycemia [11] was also included to serve as a comparison.”
BackgroundMethod
Extraction and formulation of bioactive compounds
Belščak‐Cvitanović, A., & Komes, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811290-8.00004-9 · Cited by 13
Seagrass Posidonia oceanica (L.) Delile as a marine biomarker: a metabolomic and toxicological analysis
Toniolo, C., Sotto, A. D., Giacomo, S. D., Ventura, D., Casoli, E., Belluscio, A., Nicoletti, M., & Ardizzone, G. (2018) · Ecosphere · doi:10.1002/ecs2.2054 · Cited by 13
“However, recently, the importance of this polyphenol was evidenced, being CGA used as a marker of the metabolic changes (Grace and Logan 2000) and studied for the biological activity (Farah et al. 2008, Mollica et al. 2016).”
Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases
Kim, E., Cui, J., Zhang, G., & Lee, Y. (2022) · Applied Sciences · doi:10.3390/app12041879 · Cited by 15
Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids
Stalmach, A. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00042-6 · Cited by 12
Effect of Green Coffee Bean Extract Supplementation on Body Fat Reduction in Mildly Obese Women
Kim, T., Yang, W., Park, S.-I., Lee, S.-P., Kang, M.-H., Lee, J., Park, I., Park, H., Murai, H., & Okada, T. (2012) · Journal of the Korean Society of Food Culture · doi:10.7318/kjfc/2012.27.4.407 · Cited by 11
Hydrolysis Influence on Phytochemical Composition, Antioxidant Activity, Plasma Concentration, and Tissue Distribution of Hydroethanolic Ilex paraguariensis Extract Components
Rivelli, D. P., de Almeida, R. L., Röpke, C. D., & Barros, S. B. D. M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201665t · Cited by 12
Bioassay-Guided Fractionation and In Vitro Antiproliferative Effects of Fractions ofArtemisia nilagiricaon THP-1 cell line
Gul, M. Z., Chandrasekaran, S., Manjulatha, K., Bhat, M. Y., Maurya, R., Qureshi, I. A., & Ghazi, I. A. (2016) · Nutrition and Cancer · doi:10.1080/01635581.2016.1205900 · Cited by 12
Comparison of the antioxidant activities of roasted and explosive puffed coffees
Han, S., Ko, B. S., Ahn, S. H., Noh, D. O., & Suh, H. J. (2017) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13402 · Cited by 12
“Chlorogenic acids, in many different isomeric forms, are the major phenolic compounds in coffee beans (Farah et al., 2008).”
Background
Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells
Domith, I., Duarte-Silva, A. T., Garcia, C. G., Calaza, K. D. C., Paes‐de‐Carvalho, R., & Cossenza, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.023 · Cited by 12
Effects of green coffee bean extract on C-reactive protein levels: A systematic review and meta-analysis of randomized controlled trials
Chen, H., Huang, W., Huang, X., Liang, S., Gecceh, E., Santos, H. O., Khani, V., & Jiang, X. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102498 · Cited by 12
Stimulation of brown adipose tissue by polyphenols in extra virgin olive oil
Melguizo‐Rodríguez, L., Montes, R. I., Costela-Ruiz, V. J., & García‐Martínez, O. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1799930 · Cited by 12
“This simple phenol can also be found in other foods, including green coffee beans (Farah et al. 2008).”
Background
Overview of Plant-Derived Antioxidants
Chabert, P., Auger, C., Pincemail, J., & Schini‐Kerth, V. B. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_162 · Cited by 12
Development of an assay to assess genotoxicity by particulate matter extract
Priftis, A., Papikinos, K., Koukoulanaki, M., Kerasioti, E., Stagos, D., Konstantinopoulos, K., Spandidos, D. A., Kermenidou, M., Karakitsios, S., Sarigiannis, D. A., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6171 · Cited by 12
Ligularia fischeri and its constituent 3,4-dicaffeoylquinic acid improve obesity-induced nonalcoholic fatty liver disease by regulating lipid metabolism and activating AMPK
Randy, A., Kim, M., & Nho, C. W. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.08.050 · Cited by 12
Coffee and Cardiovascular Health: A Review of Literature
Farraj, A., Akeredolu, T., Wijeyesekera, A., & Mills, C. E. (2024) · Nutrients · doi:10.3390/nu16244257 · Cited by 15
Coffee Polyphenols and High Cardiovascular Risk Parameters
Tresserra‐Rimbau, A., Medina‐Remón, A., Estruch, R., & Lamuela-Raventós, R. M. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00042-5 · Cited by 11
Influence of rye flour enzymatic biotransformation on the antioxidant capacity and transepithelial transport of phenolic acids
de Lima, F. A., Martins, I. M., Faria, A., Calhau, C., Azevedo, J., Fernandes, I., Mateus, N. F. D. C. B., & Macêdo, G. A. (2018) · Food & Function · doi:10.1039/c7fo01645j · Cited by 11
Helichrysum italicum ssp. italicum Infusion Promotes Fat Oxidation in Hepatocytes and Stimulates Energy Expenditure and Fat Oxidation after Acute Ingestion in Humans: A Pilot Study
Kenig, S., Kramberger, K., Petelin, A., Bandelj, D., Arbeiter, A. B., Višnjevec, A. M., Peeters, K., Mohorko, N., Novak, K. Š., & Pražnikar, Z. J. (2021) · Plants · doi:10.3390/plants10081516 · Cited by 11
“[13] demonstrated that over 30% of ingested cinnamic acid components were recovered in plasma, indicating that the major CGAs are highly absorbed and metabolized by humans.”
Background
The Effect of Green Coffee Supplementation on Lipid Profile, Glycemic Indices, Inflammatory Biomarkers and Anthropometric Indices in Iranian Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial
Meshkani, M., Saedisomeolia, A., Yekaninejad, M. S., Mousavi, S. A., Ildarabadi, A., & Dastjerdi, M. V. (2022) · Clinical Nutrition Research · doi:10.7762/cnr.2022.11.4.241 · Cited by 11
“Recent evidence in humans and animals demonstrated vasoreactivity improvement, antihypertensive effect, body weight loss, and modulation of glycemic indices from GC bean extract [25-27].”
Background
Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies
Grzelczyk, J., Szwajgier, D., Baranowska‐Wójcik, E., Pérez‐Sánchez, H., Carmena‐Bargueño, M., Sosnowska, B., & Budryn, G. (2023) · Nutrients · doi:10.3390/nu15102366 · Cited by 11
“Farah et al. [31] after the administration of green coffee supplements, serum concentrations of hydroxycinnamic acids were 5–10 µ mol/L, and this level was maintained for up to 8 h, In addition % was digested fractions (Figure 3B–”
Urine metabolomics shows an induction of fatty acids metabolism in healthy adult volunteers after supplementation with green coffee ( Coffea robusta L.) bean extract
Peron, G., Santarossa, D., Voinovich, D., Dall’Acqua, S., & Sut, S. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.11.002 · Cited by 11
Determination of 5-caffeoylquinic acid (5-CQA) as one of the major classes of chlorogenic acid in commercial tea and coffee samples
Grujić-Letić, N. N., Rakić, B., Šefer, E., Rakić, D., Nedeljkovic, I., Kladar, N., & Božin, B. N. (2015) · Vojnosanitetski pregled · doi:10.2298/vsp130915096g · Cited by 11
Evaluation of Chemical Composition and In-vitro Biological Activities of Three Endemic Hypericum Species from Anatolia (H. thymbrifolium, H. spectabile and H. pseudolaeve).
Özkan, E. E., Özsoy, N., Yilmaz‐Ozden, T., Özhan, G., & Mat, A. (2018) · Europe PMC (PubMed Central) · Cited by 11
Multiple catechols in human plasma after drinking caffeinated or decaffeinated coffee
Goldstein, D. S., Sullivan, P., Corrales, A., Isonaka, R., Gelsomino, J., Cherup, J., Castillo, G., & Holmes, C. S. (2021) · Journal of Chromatography B · doi:10.1016/j.jchromb.2021.122988 · Cited by 10
Spectrophotometry and chromatography analyses combined with chemometrics tools to differentiate green coffee beans into special or traditional
Gomes, W. P. C., Bortoleto, G. G., & Melchert, W. R. (2023) · Journal of Food Science · doi:10.1111/1750-3841.16807 · Cited by 10
Exploring coffee's impact: Aflatoxins, phytochemicals, and public health considerations
Kodape, A., & Kodape, A. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104991 · Cited by 10
Microbial Biotransformation of a Polyphenol-Rich Potato Extract Affects Antioxidant Capacity in a Simulated Gastrointestinal Model
Khairallah, J., Ekbatan, S. S., Sabally, K., Iskandar, M. M., Hussain, R., Nassar, A. M. K., Sleno, L., Rodes, L., Prakash, S., Donnelly, D. J., et al. (2018) · Antioxidants · doi:10.3390/antiox7030043 · Cited by 10
“2 Identification based on previous literature [19,25,32].”
Background
Untargeted profiling of field cultivated bush tea (Athrixia phylicoides DC.) based on metabolite analysis
Cecilia, M. K., Assress, H. A., Nyoni, H. H., Araya, H., Umer, M., Mudau, F. N., Ali, S. W., Afzal, M. I., Martorell, M., Salehi, B., et al. (2020) · Cellular and Molecular Biology · doi:10.14715/cmb/2020.66.4.14 · Cited by 10
Coffee intake down-regulates the hepatic gene expression of peroxisome proliferator-activated receptor gamma in C57BL/6J mice fed a high-fat diet
Takahashi, S., Egashira, K., Saito, K., Jia, H., Abe, K., & Kato, H. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.10.002 · Cited by 10
Simultaneous detoxification and preparative separation of chlorogenic acid from Eupatorium adenophorum by combined column chromatography
Liu, B., Dong, B., Yuan, X., Guo, Y., Zhang, L., & Zhao, B. (2017) · Separation Science and Technology · doi:10.1080/01496395.2017.1281300 · Cited by 10
Adding Adulterants to Coffee Reduces Bioactive Compound Levels and Antioxidant Activity
Gandra, F. P. D. P., Lima, A. R., Ferreira, E. B., de Angelis‐Pereira, M. C., & Pereira, R. G. F. A. (2017) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-5-5-5 · Cited by 10
“Chlorogenic acid and its isomers are the main components of the phenolic fraction in raw coffee beans [3,18] and 5-caffeoylquinic acid (5-CQA) is the most abundant [19].”
Background
Gut microbiota metabolism and the permeability of natural products contained in infusions from herb of European goldenrod Solidago virgaurea L.
Popowski, D., Czerwińska, M. E., Kruk, A., Pawłowska, K. A., Zentek, J., Melzig, M. F., Piwowarski, J. P., & Granica, S. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113924 · Cited by 10
Chlorogenic, Caffeic, and Ferulic Acids and Their Derivatives in Foods
Manivel, P., & Chen, X. (2021) · Springer eBooks · doi:10.1007/978-981-15-4148-3_22 · Cited by 9
Comprehensive LC‐MS/MS phenolic profiling of Arum elongatum plant and bioaccessibility of phenolics in their infusions
Özkan, G., Sakarya, F. B., Akdas, A., Atalar, M. N., Aydoğan, C., Yurt, B., & Çapanoğlu, E. (2023) · eFood · doi:10.1002/efd2.124 · Cited by 9
Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
Singh, S. K., & Varshney, M. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073321017240610060637 · Cited by 10
Evaluating the antiviral efficacy and specificity of chlorogenic acid and related herbal extracts against SARS-CoV-2 variants via spike protein binding intervention
Hsieh, W.-Y., Yu, C., Chen, C. C., Chiou, C., Green, B. D., Lee, O. K., Wu, C.-C., Doan, L. H., Huang, C. F., Huang, C. Y., et al. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.11.009 · Cited by 9
The Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review
Chipofya, E., Docrat, T. F., & Marnewick, J. L. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400670 · Cited by 8

Authors: Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S.
Affiliations: Universidade Federal do Rio de Janeiro (BR)
Naturex (France) (FR)
Corresponding author: Farah, Adriana
ORCID: Farah, Adriana
Monteiro, Mariana
Donangelo, Carmen M.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2008-12
Volume: 138
Issue: 12
Pages: 2309-2315
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.108.095554
OpenAlex: W2127688626
Cited by: 578
References: 50
Citations by year: 2026: 18 · 2025: 16 · 2024: 20 · 2023: 33 · 2022: 29 · 2021: 40 · 2020: 43 · 2019: 42 · 2018: 49 · 2017: 52 · 2016: 48 · 2015: 39 · 2014: 35 · 2013: 28 · 2012: 32
FWCI: 12.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5181 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: chlorogenic acid, green coffee bean extract, bioavailability, pharmacokinetics, caffeoylquinic acids, dicaffeoylquinic acids, cinnamic acid derivatives, urinary excretion, plasma absorption, metabolites, nutraceuticals, decaffeinated coffee
MeSH terms: Adult, Biological Availability, Caffeic Acids, Caffeine, Chlorogenic Acid, Cinnamates, Coffee, Coumaric Acids, Female, Humans, Male, Middle Aged, Propionates, Quinic Acid, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks