Cited by 578Coffee research and impactsPhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

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Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans

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Farah, Adriana, Monteiro, Mariana, Donangelo, Carmen M., Lafay, Sophie·2008·The Journal of Nutrition

DOI 10.3945/jn.108.095554

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Abstract

Chlorogenic acids (CGA) are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main CGA found in nature. Because green coffee is a major source of CGA, it has been used for production of nutraceuticals. However, data on the bioavailability of CGA from green coffee in humans are inexistent. The present study evaluated the pharmacokinetic profile and apparent bioavailability of CGA in plasma and urine of 10 healthy adults for 8 h after the consumption of a decaffeinated green coffee extract containing 170 mg of CGA. Three CQA, 3 diCQA, and caffeic, ferulic, isoferulic, and p-coumaric acids were identified in plasma by HPLC-Diode Array Detector-MS after treatment. Over 30% (33.1 +/- 23.1%) of the ingested cinnamic acid moieties were recovered in plasma, including metabolites, with peak levels from 0.5 to 8 h after treatment. CGA and metabolites identified in urine after treatment were 4-CQA, 5-CQA, and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids, totaling 5.5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans.

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“A water solution of methanol (40–80%) is the most commonly used extraction solvent in papers dealing with analyses of caffeoylquinic acids in different matrices [1,14,16,19].”
BackgroundMethod
Optimization the Ultrasonic Assisted Extraction of Chlorogenic Acid from the Artichoke (Cynara Scolymus) Leaf with Response Surface Methodology and Total Phenolic Contents
Atıcı, Y., & Bulduk, İ. (2020) · Hacettepe Journal of Biology and Chemistry · doi:10.15671/hjbc.511586 · Cited by 3
“The ultrasonic assisted extraction method is advantageous and environmentally friendly in comparison with traditional extraction methods because of being used less solvent and being performed in a short time [10-11].”
Method
Determination of Antioxidant Biomarkers in Biological Fluids
Jeszka‐Skowron, M., Podgórski, T., & Czarczyńska-Goślińska, B. (2021) · Food bioactive ingredients · doi:10.1007/978-3-030-61879-7_11 · Cited by 3
Preparation and application of caffeic acid imprinted polymer
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“For humans and mice, it has a restrictive impact on fat gathering and the body heaviness and regulates the metabolism of glucose for humans [13].”
Background
Effect of Green Coffee Bean Extract on Steroid Hormones Synthesis, Blood Lipids and Body Weight in Rats
Otaibi, S. Z. A. (2021) · International Journal of Food Science Nutrition and Dietetics · doi:10.19070/2326-3350-2100087 · Cited by 3
“Introduction Chlorogenic Acids are one of the most important Hydroxycinnamic Acids that fall under the group of phenolic acids and these acids are found in a range of foods such as fruits, vegetables, and coffee, especially green coffee (unroasted coffee beans) which are the richest natural sources of these acids [11,…”
Background
Oxidation of olive oil fortified with quercetin, caffeic acid, tyrosol and hydroxytyrosol
Etherton, A. K., & Omaye, S. T. (2015) · Nutrition & Food Science · doi:10.1108/nfs-09-2014-0083 · Cited by 3
“This mixture would resemble a diet that consisted of four cups of coffee, half a glass of wine and olive oil that was low in tyrosol and hydroxytyrosol or limited olive oil in the diet (Nardini et al., 2002; Covas et al., 2003; de Vries et al., 2001; Farah et al., 2008; Ferruzzi, 2010; Manach et al., 1998, 1998; Miró-…”
BackgroundMethod
The effect of green coffee extract supplementation on lipid profile: A systematic review of clinical trial and in-vivo studies
Nikpayam, O., Faghfouri, A. H., Tavakoli‐Rouzbehani, O. M., Jalali, S.-M., Najafi, M., & Sohrab, G. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.07.043 · Cited by 3
Determination of Chlorogenic Acid in Solid-lipid Nanoparticles: Validation by UV-spectroscopy
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Green Coffee Powder as a Clean-Label Functional Ingredient in Meat Systems: Antioxidant Performance, Molecular Docking Mechanisms, and Technological Properties
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Abelmoschus esculentus Moench L. leaf inhibited lipid peroxidation and deproteination, and caused dose-dependent spermatogenesis and impaired hormonal synchronism in Wistar rats
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An Overview of Biorefinery Waste for Microbial Production of Green Plastic in a Circular Economy
Gudapati, G., Sridevi, V., Bora, T., Bai, M. T., Dwarapureddy, A. K. P., Reddi, G. P., & Hamzah, H. T. (2025) · Food Technology and Biotechnology · doi:10.17113/ftb.63.02.25.8966 · Cited by 2
Simulateous Determination for the Contents of Caffeine and Chlorogenic Acid in Coffee Beans
Shin, J. H., & Ahn, Y. G. (2013) · The Korean Journal of Community Living Science · doi:10.7856/kjcls.2013.24.1.5 · Cited by 2
“커피 원료인 생두 는 폴리페놀의 일종인 클로로겐산(chlorogenic acid) 과 카페인 (caffeine)을 포함한 다양한 생리활성 물질이 함유되어 있다(Farah et al. 2008).”
Synthesis and Analysis of the Dietary Relevant Isomers of Chlorogenic Acids, Their Derivatives and Hydroxycinnamates
Jaiswal, R. (2011) · Cited by 2
Chlorogenic Acid Reduces Oxidative Stress in Rpe Cells
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“Chlorogenic acid treatment (1) up regulates the antioxidant enzymes activities CAT and SOD in RPE, especially in oxidatively stressed cells; (2) determine an increa se of reduced glutathione concentration and, (3) decrease intracellular ROS generation in RPE cells subjected to oxidative stress.”
Background
Development of Multilayered Chlorogenate-Peptide Based Biocomposite Scaffolds for Potential Applications in Ligament Tissue Engineering - An In Vitro Study
Pajovich, H. T., Brown, A. M., Smith, A. M., Hurley, S. K., Dorilio, J., Cutrone, N. M., & Banerjee, I. A. (2017) · Journal of biomimetics, biomaterials and biomedical engineering · doi:10.4028/www.scientific.net/jbbbe.34.37 · Cited by 2
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“However, other studies with roasted and green coffee extracts showed that considerable o-CQA amounts could be identified in human plasma [36,37].”
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Şirin, S., Dursun, H. G., & Güneş, C. E. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520623666221027100833 · Cited by 2
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Authors: Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S.
Affiliations: Universidade Federal do Rio de Janeiro (BR)
Naturex (France) (FR)
Corresponding author: Farah, Adriana
ORCID: Farah, Adriana
Monteiro, Mariana
Donangelo, Carmen M.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2008-12
Volume: 138
Issue: 12
Pages: 2309-2315
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.108.095554
OpenAlex: W2127688626
Cited by: 578
References: 50
Citations by year: 2026: 18 · 2025: 16 · 2024: 20 · 2023: 33 · 2022: 29 · 2021: 40 · 2020: 43 · 2019: 42 · 2018: 49 · 2017: 52 · 2016: 48 · 2015: 39 · 2014: 35 · 2013: 28 · 2012: 32
FWCI: 12.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5181 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: chlorogenic acid, green coffee bean extract, bioavailability, pharmacokinetics, caffeoylquinic acids, dicaffeoylquinic acids, cinnamic acid derivatives, urinary excretion, plasma absorption, metabolites, nutraceuticals, decaffeinated coffee
MeSH terms: Adult, Biological Availability, Caffeic Acids, Caffeine, Chlorogenic Acid, Cinnamates, Coffee, Coumaric Acids, Female, Humans, Male, Middle Aged, Propionates, Quinic Acid, Young Adult

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Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans

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