Nutrigenomics at the Interface of Aging, Lifespan, and Cancer Prevention

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.006 · Cited by 910 · see citing works

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works

Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review

Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0852-y · Cited by 599 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works

Melanocortin receptors in leptin effects

Seeley, R. J., Yagaloff, K. A., Fisher, S. L., Burn, P., Thiele, T. E., van Dijk, G., Baskin, D. G., & Schwartz, M. W. (1997) · Nature · doi:10.1038/37016 · Cited by 522 · see citing works

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501 · see citing works

mTOR in aging, metabolism, and cancer

Cornu, M., Albert, V., & Hall, M. N. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.12.005 · Cited by 446 · see citing works

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works

DNA repair mechanisms in cancer development and therapy

Torgovnick, A., & Schumacher, B. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00157 · Cited by 403 · see citing works

Axis of ageing: telomeres, p53 and mitochondria

Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J., Yao, X., Bronner, C. E., Zheng, B., Gordon, M. D., Reneker, J., Arnheim, N., et al. (1998) · Nature Genetics · doi:10.1038/ng0398-276 · Cited by 360 · see citing works

Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice

Fenech, M. F., El‐Sohemy, A., Cahill, L. E., Ferguson, L. R., French, T.-A. C., Tai, E. S., Milner, J. A., Koh, W., Xie, L. Y., Zucker, M., et al. (2011) · Lifestyle Genomics · doi:10.1159/000327772 · Cited by 359 · see citing works

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease

Farzaneh‐Far, R. (2010) · JAMA · doi:10.1001/jama.2009.2008 · Cited by 354 · see citing works

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · see citing works

Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes

Redman, L. M., & Ravussin, É. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3253 · Cited by 328 · see citing works

Associations between diet, lifestyle factors, and telomere length in women

Cassidy, A., Vivo, I. D., Liu, Y., Han, J., Prescott, J., Hunter, D. J., & Rimm, E. B. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28947 · Cited by 308 · see citing works

Early growth determines longevity in male rats and may be related to telomere shortening in the kidney

Jennings, B. J., Ozanne, S. E., Dorling, M. W., & Hales, C. N. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00336-1 · Cited by 303 · see citing works

The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens

Ghoshal, A. K., & Farber, E. (1984) · Carcinogenesis · doi:10.1093/carcin/5.10.1367 · Cited by 298 · see citing works

The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases

Zapata, H. J., & Quagliarello, V. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13310 · Cited by 279 · see citing works

Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study

Crous‐Bou, M., Fung, T. T., Prescott, J., Julin, B., Du, M., Sun, Q., Rexrode, K. M., Hu, F. B., & Vivo, I. D. (2014) · BMJ · doi:10.1136/bmj.g6674 · Cited by 270 · see citing works

Regulation of the human catalytic subunit of telomerase (hTERT)

Daniel, M. G., Peek, G. W., & Tollefsbol, T. O. (2012) · Gene · doi:10.1016/j.gene.2012.01.095 · Cited by 265 · see citing works

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

Meeran, S. M., Ahmed, A. A., & Tollefsbol, T. O. (2010) · Clinical Epigenetics · doi:10.1007/s13148-010-0011-5 · Cited by 257 · see citing works

Plasma Choline Metabolites and Colorectal Cancer Risk in the Women's Health Initiative Observational Study

Bae, S., Ulrich, C. M., Neuhouser, M. L., Malysheva, O., Bailey, L. B., Xiao, L., Brown, E. C., Cushing-Haugen, K. L., Zheng, Y., Cheng, T.-Y. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1835 · Cited by 253 · see citing works

Telomerase at the intersection of cancer and aging

de Jesus, B. B., & Blasco, M. A. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.06.007 · Cited by 251 · see citing works

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., & Imai, S.-I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1385-10.2010 · Cited by 237 · see citing works

Diet, nutrition and telomere length

Paul, L. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.12.001 · Cited by 227 · see citing works

Telomere Length Variations in Aging and Age-Related Diseases

Rizvi, S., Raza, S. T., & Mahdi, F. (2015) · Current Aging Science · doi:10.2174/1874609808666150122153151 · Cited by 209 · see citing works

Oxidative stress and life histories: unresolved issues and current needs

Speakman, J. R., Blount, J. D., Bronikowski, A. M., Buffenstein, R., Isaksson, C., Kirkwood, T. B. L., Monaghan, P., Ozanne, S. E., Beaulieu, M., Briga, M., et al. (2015) · Ecology and Evolution · doi:10.1002/ece3.1790 · Cited by 208 · see citing works

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S. R., An, S. S., Santhanam, L., Martin, B., Faulkner, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.018 · Cited by 206 · see citing works

Telomeres and human aging: facts and fibs

Aviv, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.51.pe43 · Cited by 198 · see citing works

p53 Isoforms: Key Regulators of the Cell Fate DecisionPreprint

Joruiz, S. M., & Bourdon, J. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026039 · Cited by 191 · see citing works

Chemotherapeutic Potential of Curcumin for Colorectal Cancer

Chauhan, D. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612023394016 · Cited by 186 · see citing works

Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation

Meeran, S. M., Katiyar, S., & Katiyar, S. K. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.12.027 · Cited by 184 · see citing works

Positive oxidative stress in aging and aging-related disease tolerance

Yan, L. (2014) · Redox Biology · doi:10.1016/j.redox.2014.01.002 · Cited by 170 · see citing works

Telomere Length, Oxidative Damage, Antioxidants and Breast Cancer Risk

Shen, J., Gammon, M. D., Terry, M. B., Wang, Q., Bradshaw, P., Teitelbaum, S. L., Neugut, A. I., & Santella, R. M. (2009) · International Journal of Cancer · doi:10.1002/ijc.24105 · Cited by 159 · see citing works

Meat subtypes and their association with colorectal cancer: Systematic review and meta‐analysis

Carr, P. R., Walter, V., Brenner, H., & Hoffmeister, M. (2015) · International Journal of Cancer · doi:10.1002/ijc.29423 · Cited by 157 · see citing works

Telomeres and Mitochondria in the Aging Heart

Moslehi, J. J., DePinho, R. A., & Sahin, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.246868 · Cited by 150 · see citing works

Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?

de Magalhães, J. P. (2012) · The FASEB Journal · doi:10.1096/fj.12-210872 · Cited by 147 · see citing works

Cellular and molecular effects of sirtuins in health and disease

Horio, Y., Hayashi, T., Kuno, A., & Kunimoto, R. (2011) · Clinical Science · doi:10.1042/cs20100587 · Cited by 137 · see citing works

A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI

Corella, D., Arnett, D. K., Tucker, K. L., Kabagambe, E. K., Tsai, M. Y., Parnell, L. D., Lai, C., Lee, Y., Warodomwichit, D., Hopkins, P. N., et al. (2011) · Journal of Nutrition · doi:10.3945/jn.111.143826 · Cited by 136 · see citing works

DNA repair and aging: The impact of the p53 family

Nicolai, S., Rossi, A., Di Daniele, N., Melino, G., Annicchiarico-Petruzzelli, M., & Raschellà, G. (2015) · Aging · doi:10.18632/aging.100858 · Cited by 118 · see citing works

Curcumin and aging

Shen, L., Parnell, L. D., Ordovás, J. M., & Lai, C. (2013) · BioFactors · doi:10.1002/biof.1086 · Cited by 112 · see citing works

Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies

Hirai, S., Takahashi, N., Goto, T., Lin, S., Uemura, T., Yu, R., & Kawada, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/367838 · Cited by 109 · see citing works

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones

Zeisel, S. H. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.10.008 · Cited by 106 · see citing works

Aging: A mitochondrial DNA perspective, critical analysis and an update

Shokolenko, I. N. (2014) · World Journal of Experimental Medicine · doi:10.5493/wjem.v4.i4.46 · Cited by 99 · see citing works

Specific nutrient combination effects on tax, NF-κB and MMP-9 in human T-cell lymphotropic virus -1 positive malignant T-lymphocytes

Harakeh, S., Azar, R., Azhar, E. I., et al. (2015) · BMC Cancer · doi:10.1186/1471-2407-15-s1-s2 · Cited by 91 · see citing works

Effect of Curcumin on Lifespan, Activity Pattern, Oxidative Stress, and Apoptosis in the Brains of Transgenic Drosophila Model of Parkinson’s Disease

Siddique, Y. H., Naz, F., & Jyoti, S. (2014) · BioMed Research International · doi:10.1155/2014/606928 · Cited by 90 · see citing works

Mismatch repair deficiency in ovarian cancer — Molecular characteristics and clinical implications

Xiao, X., Melton, D. W., & Gourley, C. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2013.12.003 · Cited by 89 · see citing works

Diet activity, and lifestyle associations with p53 mutations in colon tumors.

Slattery, M. L., Curtin, K. P., Ma, K., Edwards, S. L., Schaffer, D., Anderson, K., & Samowitz, W. S. (2002) · PubMed · Cited by 83 · see citing works

Length-dependent processing of telomeres in the absence of telomerase

Fallet, E., Jolivet, P., Soudet, J., Lisby, M., Gilson, É., & Teixeira, M. T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1328 · Cited by 79 · see citing works

Sirtuins, Metabolism, and Cancer

Martínez-Pastor, B., & Mostoslavsky, R. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00022 · Cited by 78 · see citing works

The MC4R(I251L ) Allele Is Associated with Better Metabolic Status and More Weight Loss after Gastric Bypass Surgery

Mirshahi, U. L., Still, C. D., Masker, K. K., Gerhard, G. S., Carey, D. J., & Mirshahi, T. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1549 · Cited by 72 · see citing works

Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation

Wang, Y. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.5.321 · Cited by 67 · see citing works

Meat intake, cooking methods, dietary carcinogens, and colorectal cancer risk: findings from the Colorectal Cancer Family Registry

Joshi, A. D., Kim, A., Lewinger, J. P., Ulrich, C. M., Potter, J. D., Cotterchio, M., Marchand, L. L., & Stern, M. C. (2015) · Cancer Medicine · doi:10.1002/cam4.461 · Cited by 64 · see citing works

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

Xiang, L., Nakamura, Y., Lim, Y., Yamasaki, Y., Kurokawa-Nose, Y., Maruyama, W., Osawa, T., Matsuura, A., Motoyama, N., & Tsuda, L. (2011) · Aging · doi:10.18632/aging.100396 · Cited by 64 · see citing works

Systemic regulation of mammalian ageing and longevity by brain sirtuins

Satoh, A., & Imai, S. (2014) · Nature Communications · doi:10.1038/ncomms5211 · Cited by 63 · see citing works

Telomeres, Atherosclerosis, and Human Longevity

Aviv, A., Kark, J. D., & Susser, E. (2015) · Epidemiology · doi:10.1097/ede.0000000000000280 · Cited by 61 · see citing works

Nutrition and lifestyle in healthy aging: the telomerase challenge

Boccardi, V., Paolisso, G., & Mecocci, P. (2016) · Aging · doi:10.18632/aging.100886 · Cited by 60 · see citing works

Telomere length maintenance in aging and carcinogenesis.

Aragona, M., Maisano, R., Panetta, S., Giudice, A., Morelli, M., Torre, I. L., & Torre, F. L. (2000) · International Journal of Oncology · doi:10.3892/ijo.17.5.981 · Cited by 51 · see citing works

Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome

Beavers, K. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s142 · Cited by 44 · see citing works

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

Edifizi, D., & Schumacher, B. (2015) · Biomolecules · doi:10.3390/biom5031855 · Cited by 42 · see citing works

Sibling-based association study of the PPARγ2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study

Chuang, L., Hsiung, C. A., Chen, Y.-D., et al. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100255 · Cited by 41 · see citing works

Telomere length regulation during cloning, embryogenesis and ageing

Schaetzlein, S., & Rudolph, K. L. (2004) · Reproduction Fertility and Development · doi:10.1071/rd04112 · Cited by 38 · see citing works

FTO gene variant modulates the neural correlates of visual food perception

Kühn, A. B., Feis, D., Schilbach, L., Kracht, L., Hess, M. E., Mauer, J., Brüning, J. C., & Tittgemeyer, M. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.12.049 · Cited by 38 · see citing works

Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans

Lee, E.-B., Ahn, D., Kim, B. J., Lee, S. Y., Seo, H. W., Cha, Y., Jeon, H., Eun, J. S., Seok, D., & Kim, D. K. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.075 · Cited by 36 · see citing works

Melanocortin receptor accessory proteins in adrenal disease and obesity

Jackson, D. S., Ramachandrappa, S., Clark, A., & Chan, L. F. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00213 · Cited by 32 · see citing works

Antioxidant Vitamin Intake and Mortality

Paganini‐Hill, A., Kawas, C. H., & Corrada, M. M. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu294 · Cited by 29 · see citing works

Folate Deficiency Provides Protection against Colon Carcinogenesis in DNA Polymerase β Haploinsufficient Mice

Ventrella-Lucente, L. F., Unnikrishnan, A., Pilling, A. B., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069807 · Cited by 24 · see citing works

Genome-Wide Analysis to Identify Pathways Affecting Telomere-Initiated Senescence in Budding Yeast

Chang, H.-Y., Lawless, C., Addinall, S. G., Oexle, S., Taschuk, M. L., Wipat, A., Wilkinson, D. J., & Lydall, D. A. (2011) · G3 Genes Genomes Genetics · doi:10.1534/g3.111.000216 · Cited by 23 · see citing works

Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies

Urbanski, H. F., Mattison, J. A., Roth, G. S., & Ingram, D. K. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.01.001 · Cited by 23 · see citing works

High serum folate might have a potential dual effect on risk of colorectal cancer

Chiang, F., Huang, S., Wang, H., Chen, F.-P., & Huang, Y. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.10.011 · Cited by 18 · see citing works

An overview on how components of the melanocortin system respond to different high energy diets

van den Heuvel, J. K., van Rozen, A. J., Adan, R. A. H., & la Fleur, S. E. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.019 · Cited by 17 · see citing works

Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation

Shimada, M., Kato, A., Habu, T., & Komatsu, K. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.07.017 · Cited by 10 · see citing works

Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling

Chai, B., Li, J.-Y., Zhang, W., Wu, X., Zhang, C., & Mulholland, M. W. (2010) · Peptides · doi:10.1016/j.peptides.2010.06.028 · Cited by 10 · see citing works

Telomerase: Going Beyond the Ends

de Semir, D., Nosrati, M., Li, S., et al. (2007) · Cell Cycle · doi:10.4161/cc.6.5.3980 · Cited by 10 · see citing works

GADD45α modulates curcumin sensitivity through c-Abl- and JNK-dependent signaling pathways in a mismatch repair-dependent manner

Naick, H., Jin, S., & Baskaran, R. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2654-9 · Cited by 6 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Vitamin C, Aging and Alzheimer’s Disease

Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A. (2017) · Nutrients · doi:10.3390/nu9070670 · Cited by 243 · see citing works

The Effects of Various Larval and Adult Diets on the Fecundity and Longevity of the Boll worm, Tobacco Bud worm, and Cotton Leaf worm1

Lukefahr, M. J., & Martin, D. F. (1964) · Journal of Economic Entomology · doi:10.1093/jee/57.2.233 · Cited by 36 · see citing works

Longevity, senescence, and the genome

Johnson, T. E. (1992) · Cell · doi:10.1016/0092-8674(92)90463-m · Cited by 575 · see citing works

Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process

Shi-liang, T. (2007) · Journal of Chongqing College of Education

Laboratory Evolution of Longevity and Reproductive Fitness Components in Male Fruit Flies: Mating Ability

Service, P. M. (1993) · Evolution · doi:10.2307/2410059 · Cited by 22 · see citing works

MALE GENOTYPE AFFECTS FEMALE LONGEVITY IN DROSOPHILA MELANOGASTER

Sawby, R., & Hughes, K. A. (2007) · Evolution · doi:10.1111/j.0014-3820.2001.tb00819.x · Cited by 6 · see citing works