The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues
Open accessAbstract
Differentiation and maintenance of recirculating effector memory CD8 T cells (TEM) depends on prolonged cognate Ag stimulation. Whether similar pathways of differentiation exist for recently identified tissue-resident effector memory T cells (TRM), which contribute to rapid local protection upon pathogen re-exposure, is unknown. Memory CD8αβ+ T cells within small intestine epithelium are well-characterized examples of TRM, and they maintain a long-lived effector-like phenotype that is highly suggestive of persistent Ag stimulation. This study sought to define the sources and requirements for prolonged Ag stimulation in programming this differentiation state, including local stimulation via cognate or cross-reactive Ags derived from pathogens, microbial flora, or dietary proteins. Contrary to expectations, we found that prolonged cognate Ag stimulation was dispensable for intestinal TRM ontogeny. In fact, chronic antigenic stimulation skewed differentiation away from the canonical intestinal T cell phenotype. Resident memory signatures, CD69 and CD103, were expressed in many nonlymphoid tissues including intestine, stomach, kidney, reproductive tract, pancreas, brain, heart, and salivary gland and could be driven by cytokines. Moreover, TGF-β–driven CD103 expression was required for TRM maintenance within intestinal epithelium in vivo. Thus, induction and maintenance of long-lived effector-like intestinal TRM differed from classic models of TEM ontogeny and were programmed through a novel location-dependent pathway that was required for the persistence of local immunological memory.
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Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“SI IELs were rapidly incorporated into the emerging TCM/TEM classification scheme because constitutive maintenance of cytotoxic potential was originally a defining feature of TEM (22, 52).”
BackgroundHost-Bacterial Mutualism in the Human Intestine
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Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
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Self-citationPreferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 2×
“SI IELs were rapidly incorporated into the emerging TCM/TEM classification scheme because constitutive maintenance of cytotoxic potential was originally a defining feature of TEM (22, 52).”
BackgroundSelf-citationLineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citationDynamic T cell migration program provides resident memory within intestinal epithelium
Masopust, D., Choo, D., Vezys, V., Wherry, E. J., Duraiswamy, J., Akondy, R., Wang, J., Casey, K. A., Barber, D. L., Kawamura, K. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20090858 · Cited by 628
Self-citationIntraepithelial lymphocytes of the small intestine.
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Cited by
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“Additionally, CD62L cells isolated fromblood and spleen did not recapitulate the panoply of phenotypes expressed by memory T cells isolated from the small intestinal mucosa, lung, and brain (Hawke et al., 1998; Hogan et al., 2001; Kim et al., 1998; Masopust et al., 2001a; van der Most et al., 2003).”
BackgroundInfluentialSelf-citationTissue-resident memory T cells: local specialists in immune defence
Mueller, S. N., & Mackay, L. K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.3 · Cited by 1,006
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Intravascular staining for discrimination of vascular and tissue leukocytes
Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812
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Metadata
- Authors
- Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V., & Masopust, D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05
- Volume
- 188
- Issue
- 10
- Pages
- 4866-4875
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2125967520
- Cited by
- 639
- References
- 9
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K., Vezys, V., & Masopust, D. (2012). Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1200402
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