Cited by 322Immune cells in cancerMicroRNA in disease regulationMacrophage Migration Inhibitory Factor

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MicroRNA let-7c Regulates Macrophage Polarization

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Banerjee, Sami, Xie, Na, Cui, Huachun, Tan, Zheng, Yang, Shanzhong, Icyuz, Mert, Abraham, Edward, Liu, Gang·2013·The Journal of Immunology

DOI 10.4049/jimmunol.1202496PMC PMC3679284

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Abstract

Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined. In this study, we found that miRNA let-7c is expressed at a higher level in M-BMM (M2 macrophages) than in GM-BMM (M1 macrophages). let-7c levels are also greater in alveolar macrophages from fibrotic lungs as compared with those from normal lungs. let-7c expression was decreased when M-BMM converted to GM-BMM, whereas it increased when GM-BMM converted to M-BMM. LPS stimulation reduced let-7c expression in M-BMM. We found that overexpression of let-7c in GM-BMM diminished M1 phenotype expression while promoting polarization to the M2 phenotype. In contrast, knockdown of let-7c in M-BMM promoted M1 polarization and diminished M2 phenotype expression. We found that let-7c targets C/EBP-δ, a transcriptional factor that plays an important role in inflammatory response. Furthermore, we found that let-7c regulates bactericidal and phagocytic activities of macrophages, two functional phenotypes implicated in macrophage polarization. Our data suggest that the miRNA let-7c plays an important role in regulating macrophage polarization.

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Authors: Banerjee, S., Xie, N., Cui, H., Tan, Z., Yang, S., Icyuz, M., Abraham, E., & Liu, G.
Affiliations: University of Alabama at Birmingham (US)
Wake Forest University Health Sciences (US)
Corresponding author: Banerjee, Sami
Xie, Na
Cui, Huachun
Tan, Zheng
Yang, Shanzhong
Icyuz, Mert
Liu, Gang
ORCID: Banerjee, Sami
Xie, Na
Tan, Zheng
Yang, Shanzhong
Icyuz, Mert
Abraham, Edward
Liu, Gang
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2013-06
Volume: 190
Issue: 12
Pages: 6542-6549
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.1202496
PMC: PMC3679284
OpenAlex: W1927296860
Cited by: 320
References: 62
Citations by year: 2026: 5 · 2025: 18 · 2024: 24 · 2023: 20 · 2022: 28 · 2021: 33 · 2020: 26 · 2019: 26 · 2018: 31 · 2017: 22 · 2016: 21 · 2015: 29 · 2014: 17 · 2013: 7
FWCI: 13.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 076206, R21HL097218, HL-105473, R01HL105473, R01HL076206, HL-097218)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048311)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: let-7c microRNA, macrophage polarization, M1/M2 macrophages, C/EBPδ, alveolar macrophages, pulmonary fibrosis, lipopolysaccharide, phagocytosis, bactericidal activity, bone marrow-derived macrophages
MeSH terms: Animals, Cell Differentiation, Flow Cytometry, Macrophages, Mice, Inbred BALB C, Mice, Inbred C57BL, Phenotype, Transfection, Blotting, Western, Cell Polarity, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Real-Time Polymerase Chain Reaction

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MicroRNA let-7c Regulates Macrophage Polarization

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