The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation
Open accessAbstract
In vivo control of Mycobacterium tuberculosis reflects the balance between host immunity and bacterial evasion strategies. Effector Th1 cells that mediate protective immunity by depriving the bacterium of its intracellular niche are regulated to prevent overexuberant inflammation. One key immunoregulatory molecule is Tim3. Although Tim3 is generally recognized to downregulate Th1 responses, we recently described that its interaction with Galectin-9 expressed by M. tuberculosis–infected macrophages stimulates IL-1β secretion, which is essential for survival in the mouse model. Why IL-1β is required for host resistance to M. tuberculosis infection is unknown. In this article, we show that IL-1β directly kills M. tuberculosis in murine and human macrophages and does so through the recruitment of other antimicrobial effector molecules. IL-1β directly augments TNF signaling in macrophages through the upregulation of TNF secretion and TNFR1 cell surface expression, and results in activation of caspase-3. Thus, IL-1β and downstream TNF production lead to caspase-dependent restriction of intracellular M. tuberculosis growth.
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Cites
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
Identification of Tim4 as a phosphatidylserine receptor
Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180
Identification of nitric oxide synthase as a protective locus against tuberculosis
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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685
A Family of IFN-γ–Inducible 65-kD GTPases Protects Against Bacterial Infection
Kim, B.-H., Shenoy, A. R., Kumar, P., Das, R., Tiwari, S., & MacMicking, J. D. (2011) · Science · doi:10.1126/science.1201711 · Cited by 494
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Self-citationThorp, E., Subramanian, M., & Tabas, I. (2011) · European Journal of Immunology · doi:10.1002/eji.201141719 · Cited by 107
Cited by
TIM3 comes of age as an inhibitory receptor
Wolf, Y., Anderson, A. C., & Kuchroo, V. K. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0224-6 · Cited by 959
Self-citationGleeson, L. E., Sheedy, F. J., Palsson-McDermott, E. M., Triglia, D., O’Leary, S. M., O’Sullivan, M. P., O’Neill, L. A. J., & Keane, J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501612 · Cited by 319
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis
Mishra, B. B., Lovewell, R. R., Olive, A. J., Zhang, G., Wang, W., Eugenin, E., Smith, C. M., Phuah, J. Y., Long, J. E., Dubuke, M. L., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.72 · Cited by 284
Xue, Q., Lu, Y., Eisele, M. R., Sulistijo, E. S., Khan, N., Fan, R., & Miller-Jensen, K. (2015) · Science Signaling · doi:10.1126/scisignal.aaa2155 · Cited by 143
Lin, A. E., Beasley, F. C., Keller, N., Hollands, A., Urbano, R., Troemel, E. R., Hoffman, H. M., & Nizet, V. (2015) · mBio · doi:10.1128/mbio.00133-15 · Cited by 46
Metadata
- Authors
- Jayaraman, P., Sada-Ovalle, I., Nishimura, T., Anderson, A. C., Kuchroo, V. K., Remold, H. G., & Behar, S. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04
- Volume
- 190
- Issue
- 8
- Pages
- 4196-4204
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2153699751
- Cited by
- 214
- References
- 8
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation. https://app.cochat.ai/papers/10.4049/jimmunol.1202688
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- Jayaraman, P., Sada-Ovalle, I., Nishimura, T., Anderson, A. C., Kuchroo, V. K., Remold, H. G., & Behar, S. M. (2013). IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1202688
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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