The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Mechanisms of Jak/STAT Signaling in Immunity and Disease
Open accessAbstract
More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for membrane-to-nucleus signaling and explains how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene expression, it also has become a prototype for transition from bench to bedside, culminating in the development and clinical implementation of pathway-specific therapeutics. This brief review synthesizes our current understanding of Jak/STAT biology while taking stock of the lessons learned and the challenges that lie ahead.
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Citations
Cites
STATs in cancer inflammation and immunity: a leading role for STAT3
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Super-enhancers in the control of cell identity and disease
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JAKs and STATs in immunity, immunodeficiency, and cancer
O'Shea, J. J., Holland, S. M., & Staudt, L. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1202117 · Cited by 927
Self-citationSerine phosphorylation of STATs
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Vercelli, D. (2008) · Nature Reviews Immunology · doi:10.1038/nri2257 · Cited by 635
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“In Th cells, thousands of binding sites have been mapped for each family member, sometimes proximal to transcriptional start sites, as would have been predicted, but more often distal, typically associated with enhancers or other cis-regulatory elements (10).”
BackgroundSelf-citationReversible methylation of promoter-bound STAT3 by histone-modifying enzymes
Yang, J., Huang, J., Dasgupta, M., Sears, N., Miyagi, M., Wang, B., Chance, M. R., Chen, X., Du, Y., Wang, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016147107 · Cited by 340
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Cited by
Mechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Self-citationBanerjee, S., Biehl, A., Gadina, M., Hasni, S., & Schwartz, D. M. (2017) · Drugs · doi:10.1007/s40265-017-0701-9 · Cited by 1,206
The role of JAK/STAT signaling pathway and its inhibitors in diseases.
Xin, P., Xu, X., Deng, C., Liu, S., Wang, Y., Zhou, X., Ma, H., Wei, D., & Sun, S. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106210 · Cited by 1,010
Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease
Sharma, M., Leung, D., Momenilandi, M., Jones, L. C. W., Pacillo, L., James, A. E., Murrell, J. R., Delafontaine, S., Maimaris, J., Vaseghi-Shanjani, M., et al. (2023) · Journal of Experimental Medicine · doi:10.1084/jem.20221755 · Cited by 125
Self-citationDevelopment of Selective Covalent Janus Kinase 3 Inhibitors
Tan, L., Akahane, K., McNally, R., Reyskens, K. M. S. E., Ficarro, S. B., Liu, S., Herter-Sprie, G. S., Koyama, S., Pattison, M. J., Labella, K., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00710 · Cited by 122
Metadata
- Authors
- Villarino, A. V., Kanno, Y., Ferdinand, J. R., & O’Shea, J. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-01-01
- Volume
- 194
- Issue
- 1
- Pages
- 21-27
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1671779243
- Cited by
- 552
- References
- 14
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Villarino, A. V., Kanno, Y., Ferdinand, J. R., & O’Shea, J. J. (2014). Mechanisms of Jak/STAT Signaling in Immunity and Disease. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1401867
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