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Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro.
Abstract
Transforming growth factor-beta (TGF-beta) has been shown to be produced in the central nervous system (CNS). The functions of TGF-beta, however, remain to be elucidated. We investigated the effects of TGF-beta on the proliferation, activation, and cytokine production of isolated microglia in vitro. TGF-beta dose-dependently suppressed the acid phosphatase activity of and formation of superoxide anion by LPS activated microglia. It also suppressed the IFN-gamma-induced expression of class II MHC Ag- and the production of cytokines, IL-1, IL-6, and TNF-alpha, by these cells. TGF-beta also inhibited the proliferation of microglia that was induced by either GM-CSF or M-CSF. Because various immunoregulatory cytokines are produced in the CNS that serve as autocrine or paracrine mediators it is suggested that TGF-beta could be a negative regulator in the CNS cytokine network. It may play a role in the development of various disease processes in the CNS by inhibiting the function of microglia in inflammation or in immunoregulation.
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Self-citationTGFβ signalling plays an important role in IL4-induced alternative activation of microglia
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Metadata
- Authors
- Suzumura, A., Sawada, M., Yamamoto, H., & Marunouchi, T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-08
- Volume
- 151
- Issue
- 4
- Pages
- 2150-2158
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1537407495
- Cited by
- 305
- References
- 0
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
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