Cited by 200Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyT-cell and B-cell Immunology

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Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

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Goverse, Gera, Molenaar, Rosalie, Macia, Laurence, Tan, Jian, Erkelens, Martje N, Konijn, Tanja, Knippenberg, Marlene, Cook, Emma C L, Hanekamp, Diana, Veldhoen, Marc, Hartog, Anita, Roeselers, Guus, Mackay, Charles R, Mebius, Reina E·2017·The Journal of Immunology

DOI 10.4049/jimmunol.1600165

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Abstract

The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the vitamin A-converting enzyme RALDH1 in intestinal epithelial cells in vivo and in vitro, respectively. Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A-converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. Moreover, we show that the consumption of dietary fiber can alter the composition of SCFA-producing microbiota and SCFA production in the small intestines. In conclusion, our data illustrate that dietary adjustments affect small intestinal epithelial cells and can be used to modulate the mucosal immune system.

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Authors: Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., Hartog, A., Roeselers, G., Mackay, C. R., & Mebius, R. E.
Affiliations: Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Monash University (AU)
Babraham Institute (GB)
Utrecht University (NL)
Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author: Mebius, Reina E
ORCID: Macia, Laurence
Erkelens, Martje N
Knippenberg, Marlene
Cook, Emma C L
Hanekamp, Diana
Veldhoen, Marc
Roeselers, Guus
Mackay, Charles R
Mebius, Reina E
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2017-03-01
Volume: 198
Issue: 5
Pages: 2172-2181
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.1600165
OpenAlex: W2579076699
Cited by: 200
References: 53
Citations by year: 2026: 5 · 2025: 17 · 2024: 14 · 2023: 21 · 2022: 30 · 2021: 25 · 2020: 32 · 2019: 21 · 2018: 24 · 2017: 10
FWCI: 9.72
Type: journal article
Language: en
Open access: green
pure.amsterdamumc.nl
Licence: other-oa
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
TNO Repository (submittedVersion)
Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Vrije Universiteit Amsterdam
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91856612)
Medical Research Council
Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0409, BB/E021638/1, BBS/E/B/000C0427, BBS/E/B/0000S042)
National Health and Medical Research Council (1068890)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: short-chain fatty acids, dietary fiber, intestinal epithelial cells, ALDH1A1, vitamin A, tolerogenic dendritic cells, regulatory T cells, IgA, gut microbiota, mucosal immunity, mesenteric lymph nodes, small intestine
MeSH terms: Aldehyde Dehydrogenase 1 Family, Animals, Cells, Cultured, Dendritic Cells, Diet, Epithelial Cells, Fatty Acids, Volatile, Immunoglobulin A, Immune Tolerance, Intestinal Mucosa, Isoenzymes, Mice, Inbred C57BL, Receptors, Nicotinic, Vitamin A, Immunity, Mucosal, Receptors, G-Protein-Coupled, T-Lymphocytes, Regulatory, Retinal Dehydrogenase, Mice, Microbiota

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Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

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