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Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells
Open accessAbstract
The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the vitamin A-converting enzyme RALDH1 in intestinal epithelial cells in vivo and in vitro, respectively. Furthermore, our data showed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the activity of vitamin A-converting enzymes in mesenteric lymph node dendritic cells, along with increased numbers of intestinal regulatory T cells and a higher production of luminal IgA. Moreover, we show that the consumption of dietary fiber can alter the composition of SCFA-producing microbiota and SCFA production in the small intestines. In conclusion, our data illustrate that dietary adjustments affect small intestinal epithelial cells and can be used to modulate the mucosal immune system.
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Metadata
- Authors
- Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., Hartog, A., Roeselers, G., Mackay, C. R., & Mebius, R. E.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Monash University (AU)
- Babraham Institute (GB)
- Utrecht University (NL)
- Netherlands Organisation for Applied Scientific Research (NL)
- Corresponding author
- Mebius, Reina E
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-01
- Volume
- 198
- Issue
- 5
- Pages
- 2172-2181
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2579076699
- Cited by
- 200
- References
- 53
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 14 · 2023: 21 · 2022: 30 · 2021: 25 · 2020: 32 · 2019: 21 · 2018: 24 · 2017: 10
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Vrije Universiteit Amsterdam
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91856612)
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0409, BB/E021638/1, BBS/E/B/000C0427, BBS/E/B/0000S042)
- National Health and Medical Research Council (1068890)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- short-chain fatty acids, dietary fiber, intestinal epithelial cells, ALDH1A1, vitamin A, tolerogenic dendritic cells, regulatory T cells, IgA, gut microbiota, mucosal immunity, mesenteric lymph nodes, small intestine
- MeSH terms
- Aldehyde Dehydrogenase 1 Family, Animals, Cells, Cultured, Dendritic Cells, Diet, Epithelial Cells, Fatty Acids, Volatile, Immunoglobulin A, Immune Tolerance, Intestinal Mucosa, Isoenzymes, Mice, Inbred C57BL, Receptors, Nicotinic, Vitamin A, Immunity, Mucosal, Receptors, G-Protein-Coupled, T-Lymphocytes, Regulatory, Retinal Dehydrogenase, Mice, Microbiota
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