Stromal cell niches in the inflamed central nervous system.
Abstract
Inflammation in the CNS must be tightly regulated to respond efficiently to infection with neurotropic pathogens. Access of immune cells to the CNS and their positioning within the tissue are controlled by stromal cells that construct the barriers of the CNS. Although the role of the endothelium in regulating the passage of leukocytes and small molecules into the CNS has been studied extensively, the contribution of fibroblastic stromal cells as portals of entry into the CNS was only recently uncovered. We review the critical immune-stimulating role of meningeal fibroblasts in promoting recruitment and retention of lymphocytes during CNS inflammation. Activated meningeal fibroblastic stromal cells have the capacity to rapidly elaborate an immune-competent niche that sustains protective immune cells entering the CNS from the draining cervical lymph node. Such stromal cell niches can ultimately foster the establishment of tertiary lymphoid tissues during chronic neuroinflammatory conditions.
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The presentation of MS induced leptomeningeal inflammation can be variable, ranging from disorganized collections of immune cells to organized ectopic lymphoid follicle-like structures, and these ectopic lymph structures are potentiated by leptomeningeal fibroblasts which form a reticular cell network consisting of activated fibroblasts in a scaffold-like structure that might be driven by a subset
“The presentation of MS induced leptomeningeal inflammation can be variable, ranging from disorganized collections of immune cells to organized ectopic lymphoid follicle-like structures”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Pikor et al., 2017
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Additional file 1 of Impact of aging on meningeal gene expression
Neutzner, M., Kohler, C., Frank, S., Killer, H. E., & Neutzner, A. (2024) · Figshare · doi:10.6084/m9.figshare.26566754
- Authors
- Pikor, N. B., Cupovic, J., Onder, L., Gommerman, J. L., & Ludewig, B.
- Affiliations
- Kantonsspital St. Gallen (CH)
- University of Toronto (CA)
- Corresponding author
- Cupovic, Jovana
- Onder, Lucas
- Ludewig, Burkhard
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-03-01
- Volume
- 198
- Issue
- 5
- Pages
- 1775-1781
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2592192503
- Cited by
- 33
- References
- 91
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 8 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- meningeal fibroblasts, neuroinflammation, lymphocyte recruitment, lymphocyte retention, cervical lymph nodes, tertiary lymphoid tissue, blood-brain barrier, chronic neuroinflammation
- MeSH terms
- Animals, Blood-Brain Barrier, Cell Movement, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Fibroblasts, Humans, Inflammation, Lymph Nodes, Lymphocytes, Stromal Cells
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