The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells
Abstract
Although exogeneous “danger” signals such as LPS can activate APC to produce a Th1 response, the nature of events initiating a Th2 response is controversial. We now show that pathogen-derived products have the capacity to induce bone marrow-derived dendritic cell cultures to acquire a phenotype that promotes the differentiation of naive CD4+ T cells toward either a Th1 or Th2 phenotype. Thus, LPS-matured dendritic cells (DC1) promote a Th1 response (increased generation of IFN-γ and reduced production of IL-4) by Ag-stimulated CD4+ T cells from the DO.11.10 transgenic mouse expressing a TCR specific for an OVA peptide (OVA323–339). In contrast, a phosphorylcholine-containing glycoprotein, ES-62, secreted by the filarial nematode, Acanthocheilonema viteae, which generates a Th2 Ab response in vivo, is found to induce the maturation of dendritic cells (DC2) with the capacity to induce Th2 responses (increased IL-4 and decreased IFN-γ). In addition, we show that the switch to either Th1 or Th2 responses is not effected by differential regulation through CD80 or CD86 and that a Th2 response is achieved in the presence of IL-12.
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Cited by
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New Paradigms in Type 2 Immunity
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Chronic helminth infections induce immunomodulation: Consequences and mechanisms
van Riet, E., Hartgers, F. C., & Yazdanbakhsh, M. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.03.009 · Cited by 393
Metadata
- Authors
- Whelan, M., Harnett, M. M., Houston, K. M., Patel, V., Harnett, W., & Rigley, K. P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-06
- Volume
- 164
- Issue
- 12
- Pages
- 6453-6460
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1641010283
- Cited by
- 324
- References
- 28
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Whelan, M., Harnett, M. M., Houston, K. M., Patel, V., Harnett, W., & Rigley, K. P. (2000). A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.164.12.6453
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