Cited by 967Wound Healing and TreatmentsLiver physiology and pathologyMacrophage Migration Inhibitory Factor

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Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

Abe, Riichiro, Donnelly, Seamas C, Peng, Tina, Bucala, Richard, Metz, Christine N·2001·The Journal of Immunology

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Abstract

Fibrocytes are a distinct population of blood-borne cells that display a unique cell surface phenotype (collagen I+/CD11b+/CD13+/CD34+/CD45RO+/MHC class II+/CD86+) and exhibit potent immunostimulatory activities. Circulating fibrocytes rapidly enter sites of tissue injury, suggesting an important role for these cells in wound repair. However, the regulatory processes that govern the differentiation of blood-borne fibrocytes and the mechanisms that underlie the migration of these cells to wound sites are currently not known. We report herein that ex vivo cultured fibrocytes can differentiate from a CD14+-enriched mononuclear cell population and that this process requires contact with T cells. Furthermore, we demonstrate that TGF-β1 (1–10 ng/ml), an important fibrogenic and growth-regulating cytokine involved in wound healing, increases the differentiation and functional activity of cultured fibrocytes. Because fibrocytes home to sites of tissue injury, we examined the role of chemokine/chemokine receptor interactions in fibrocyte trafficking. We show that secondary lymphoid chemokine, a ligand of the CCR7 chemokine receptor, acts as a potent stimulus for fibrocyte chemotaxis in vitro and for the homing of injected fibrocytes to sites of cutaneous tissue injury in vivo. Finally, we demonstrate that differentiated, cultured fibrocytes express α smooth muscle actin and contract collagen gels in vitro, two characteristic features of wound-healing myofibroblasts. These data provide important insight into the control of fibrocyte differentiation and trafficking during tissue repair and significantly expand their potential role during wound healing.

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Authors: Abe, R., Donnelly, S. C., Peng, T., Bucala, R., & Metz, C. N.
Affiliations: Laboratory of Vascular Biology, The Picower Institute for Medical Research , Manhasset, NY 11030
Laboratory of Medical Biochemistry, The Picower Institute for Medical Research , Manhasset, NY 11030
Corresponding author: Abe, Riichiro
Peng, Tina
ORCID: Abe, Riichiro
Donnelly, Seamas C
Bucala, Richard
Metz, Christine N
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2001-06
Volume: 166
Issue: 12
Pages: 7556-7562
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.166.12.7556
OpenAlex: W4248565951
Cited by: 967
References: 40
Citations by year: 2026: 13 · 2025: 15 · 2024: 22 · 2023: 25 · 2022: 28 · 2021: 23 · 2020: 37 · 2019: 30 · 2018: 34 · 2017: 31 · 2016: 43 · 2015: 47 · 2014: 58 · 2013: 59 · 2012: 68
FWCI: 27.32
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: fibrocytes, fibrocyte differentiation, wound healing, TGF-β1, CCR7, tissue damage, myofibroblasts, alpha-smooth muscle actin, collagen gel contraction
MeSH terms: Animals, Blood Cells, Cell Differentiation, Cell Movement, Cells, Cultured, Collagen, Female, Fibroblasts, Fibrosis, Gels, Humans, Injections, Intravenous, Mice, Inbred BALB C, Stem Cells, Wound Healing, Transforming Growth Factor beta, Lipopolysaccharide Receptors, Receptors, Chemokine, Stem Cell Transplantation, Mice, Transforming Growth Factor beta1

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Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

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