Cited by 967Wound Healing and TreatmentsLiver physiology and pathologyMacrophage Migration Inhibitory Factor

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

Abe, Riichiro, Donnelly, Seamas C, Peng, Tina, Bucala, Richard, Metz, Christine N·2001·The Journal of Immunology

Open this paper in CoChat — free account

Abstract

Fibrocytes are a distinct population of blood-borne cells that display a unique cell surface phenotype (collagen I+/CD11b+/CD13+/CD34+/CD45RO+/MHC class II+/CD86+) and exhibit potent immunostimulatory activities. Circulating fibrocytes rapidly enter sites of tissue injury, suggesting an important role for these cells in wound repair. However, the regulatory processes that govern the differentiation of blood-borne fibrocytes and the mechanisms that underlie the migration of these cells to wound sites are currently not known. We report herein that ex vivo cultured fibrocytes can differentiate from a CD14+-enriched mononuclear cell population and that this process requires contact with T cells. Furthermore, we demonstrate that TGF-β1 (1–10 ng/ml), an important fibrogenic and growth-regulating cytokine involved in wound healing, increases the differentiation and functional activity of cultured fibrocytes. Because fibrocytes home to sites of tissue injury, we examined the role of chemokine/chemokine receptor interactions in fibrocyte trafficking. We show that secondary lymphoid chemokine, a ligand of the CCR7 chemokine receptor, acts as a potent stimulus for fibrocyte chemotaxis in vitro and for the homing of injected fibrocytes to sites of cutaneous tissue injury in vivo. Finally, we demonstrate that differentiated, cultured fibrocytes express α smooth muscle actin and contract collagen gels in vitro, two characteristic features of wound-healing myofibroblasts. These data provide important insight into the control of fibrocyte differentiation and trafficking during tissue repair and significantly expand their potential role during wound healing.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.166.12.7556

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., & Springer, T. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1101 · Cited by 1,482
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala, R., Spiegel, L. A., Chesney, J. A., Hogan, M. M., & Cerami, A. (1994) · Molecular Medicine · doi:10.1007/bf03403533 · Cited by 1,307
Self-citation
CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.
Zhou, L., & Tedder, T. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2588 · Cited by 1,090
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.
Sime, P. J., Xing, Z., Graham, F. L., Csaky, K. G., & Gauldie, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119590 · Cited by 1,050
Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization
Gunn, M. D., Kyuwa, S., Tam‐Amersdorfer, C., Kakiuchi, T., Matsuzawa, A., Williams, L. T., & Nakano, H. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.451 · Cited by 1,019
Myofibroblasts. I. Paracrine cells important in health and disease
Powell, D. W., Mifflin, R. C., Valentich, J. D., Crowe, S. E., Saada, J. I., & West, A. B. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.1.c1 · Cited by 974
Cutting Edge: Secondary Lymphoid-Tissue Chemokine (SLC) and CC Chemokine Receptor 7 (CCR7) Participate in the Emigration Pathway of Mature Dendritic Cells from the Skin to Regional Lymph Nodes
Saeki, H., Moore, A. M., Brown, M. J., & Hwang, S. T. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2472 · Cited by 623
Mechanisms of Myofibroblast Activity and Phenotypic Modulation
Serini, G., & Gabbiani, G. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4543 · Cited by 592
TGF- and fibrosis
Branton, M., & Kopp, J. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00250-6 · Cited by 574
The Compliance of Collagen Gels Regulates Transforming Growth Factor-β Induction of α-Smooth Muscle Actin in Fibroblasts
Arora, P. D., Narani, N., & McCulloch, C. A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65334-5 · Cited by 474

Show all 40 references

Research works printed but not linked: 42

1963, N. Engl. J. Med., 1367
1994, Mol. Med., 71
1997, Proc. Natl. Acad. Sci. USA, 6307
1999, Mol. Med., 46
1998, J. Immunol., 419
1999, Am. J. Pathol., 2087
1999, Am. J. Pathol., 871
1998, J. Exp. Med., 297
1996, J. Exp. Med., 1101
1998, Life Sci., 1779
1999, J. Clin. Invest., 1097
1998, J. Clin. Invest., 1933
1998, FEBS Lett., 188
1999, J. Immunol., 2472
1999, J. Immunol., 3985
1997, J. Biol. Chem., 30911
2000, Exp. Cell Res., 180
1999, Exp. Cell Res., 273
1999, Am. J. Physiol, C1
1998, J. Immunol., 419
1997, Biochem. Soc. Trans., 520
1995, Adv. Exp. Med. Biol., 75
1996, J. Immunol., 3850
1996, Proc. Natl. Acad. Sci. USA, 2588
1997, Eur. J. Immunol., 431
1999, Immunity, 625
1999, J. Immunol., 3231
1999, Microbes. Infect., 1349
1999, J. Am. Coll. Surg., 271
1999, Am. J. Respir. Cell Mol. Biol., 658
1999, J. Surg. Res., 194
1987, J. Surg. Res., 622
1996, J. Clin. Invest., 2894
1999, Springer Semin. Immunopathol., 385
1999, J. Immunol., 5693
1997, J. Clin. Invest., 768
1999, Curr. Top. Pathol., 35
1999, J. Immunol., 2472
2000, Am. J. Pathol., 1133
1999, J. Exp. Med., 451
1998, Blood, 2886
1997, Eur. J. Immunol., 215

Sorted by citations

Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715
Nonresolving Inflammation
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
The Myofibroblast
Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068
Molecular and cellular mechanisms of liver fibrosis and its regression
Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024
Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980
“If the wound condition is long lasting, fibroblasts in the wounds may also originate from fibrocytes, which is a group of bone marrow-derived mesenchymal progenitor cells [37, 38].”
Background
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809
Formation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658
Cardiac Fibrosis: The Fibroblast Awakens
Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016) · Circulation Research · doi:10.1161/circresaha.115.306565 · Cited by 1,596
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589
Transforming growth factor–β in tissue fibrosis
Frangogiannis, N. G. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190103 · Cited by 1,377
Systemic sclerosis: a prototypic multisystem fibrotic disorder
Varga, J., & Abraham, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31139 · Cited by 1,188
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, R. J., Burdick, M. D., Hong, K. M., Lutz, M., Murray, L. A., Xue, Y., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20997 · Cited by 1,071
Role of tissue stroma in cancer cell invasion
De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042
Fibroblasts and myofibroblasts in wound healing
Desmouliere, A., Darby, I. A., Laverdet, B., & Bonté, F. (2014) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s50046 · Cited by 1,039
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
Rock, J. R., Barkauskas, C. E., Cronce, M. J., Xue, Y., Harris, J. R., Liang, J., Noble, P. W., & Hogan, B. L. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117988108 · Cited by 1,048
Cardiac Fibroblast
Souders, C. A., Bowers, S., & Baudino, T. A. (2009) · Circulation Research · doi:10.1161/circresaha.109.209809 · Cited by 1,018
Structural and functional characterisation of cardiac fibroblasts
Camelliti, P., Borg, T. K., & Kohl, P. K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.020 · Cited by 929
Perspective Article: Tissue repair, contraction, and the myofibroblast
Desmoulière, A., Chaponnier, C., & Gabbiani, G. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130102.x · Cited by 892
Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney
Lin, S., Kisseleva, T., Brenner, D. A., & Duffield, J. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080433 · Cited by 860
Pulmonary fibrosis: pathogenesis, etiology and regulation
Wilson, M. S., & Wynn, T. A. (2009) · Mucosal Immunology · doi:10.1038/mi.2008.85 · Cited by 838
Wound healing, fibroblast heterogeneity, and fibrosis
desJardins-Park, H. E., Mascharak, S., Griffin, M., Wan, D. C., & Longaker, M. T. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.006 · Cited by 835
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
Metcalfe, A. D., & Ferguson, M. W. J. (2006) · Journal of The Royal Society Interface · doi:10.1098/rsif.2006.0179 · Cited by 799
Wound healing and the role of fibroblasts
Bainbridge, P. (2013) · Journal of Wound Care · doi:10.12968/jowc.2013.22.8.407 · Cited by 783
Wound repair at a glance
Shaw, T. J., & Martin, P. B. (2009) · Journal of Cell Science · doi:10.1242/jcs.031187 · Cited by 788
Mesenchymal Stem Cells as Therapeutics
Parekkadan, B., & Milwid, J. M. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105309 · Cited by 771
Bone marrow–derived progenitor cells in pulmonary fibrosis
Hashimoto, N., Jin, H., Liu, T., Chensue, S. W., & Phan, S. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18847 · Cited by 724
Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma
Schmidt, M., Sun, G. Y., Stacey, M. A., Mori, L., & Mattoli, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.380 · Cited by 633
Fibroblasts and myofibroblasts in wound healing: Force generation and measurement
Li, B., & Wang, J. H.-C. (2011) · Journal of Tissue Viability · doi:10.1016/j.jtv.2009.11.004 · Cited by 594
Fibroblast Differentiation in Wound Healing and Fibrosis
Darby, I. A., & Hewitson, T. D. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)57004-x · Cited by 625
The origin of fibroblasts and mechanism of cardiac fibrosis
Krenning, G., Zeisberg, E. M., & Kalluri, R. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22322 · Cited by 601
Epithelial-mesenchymal transition in tissue repair and fibrosis
Stone, R. C., Pastar, I., Ojeh, N. O., Chen, V., Liu, S., Garzon, K. I., & Tomic‐Canic, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2464-0 · Cited by 591
The stroma reaction myofibroblast: a key player in the control of tumor cell behavior
Desmoulière, A., Guyot, C., & Gabbiani, G. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041802ad · Cited by 551
Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530
Circulating fibrocytes: collagen-secreting cells of the peripheral blood
Quan, T. E., Cowper, S. E., Wu, S.-P., Bockenstedt, L. K., & Bucala, R. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.10.005 · Cited by 527
Self-citation
Inflammation and fibrosis
Mack, M. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.010 · Cited by 535
Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis
Moeller, A., Gilpin, S. E., Ask, K., Cox, G., Cook, D., Gauldie, J., Margetts, P. J., Farkas, L., Dobranowski, J., Boylan, C., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1534oc · Cited by 525
Contribution of Bone Marrow–Derived Cells to Skin: Collagen Deposition and Wound Repair
Fathke, C., Wilson, L., Hutter, J., Kapoor, V., Smith, A. N., Hocking, A. M., & Isik, F. F. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-812 · Cited by 495
Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and Fibroblasts
Pilling, D., Fan, T., Huang, D. S., Kaul, B., & Gomer, R. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007475 · Cited by 495
Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing
Greaves, N. S., Ashcroft, K. J., Baguneid, M. S., & Bayat, A. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.07.008 · Cited by 493
Oxidative stress and glutathione in TGF-β-mediated fibrogenesis
Liu, R.-M., & Pravia, K. A. G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.026 · Cited by 473
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
Kisseleva, T., Uchinami, H., Feirt, N. M., Bustamante, O. Q., Segovia, J. C., Schwabe, R. F., & Brenner, D. A. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.04.014 · Cited by 476
Fibroblasts and myofibroblasts: Their source, function and role in disease
McAnulty, R. J. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.11.005 · Cited by 455
Transforming Growth Factor-β1 Induces the Differentiation of Myogenic Cells into Fibrotic Cells in Injured Skeletal Muscle
Li, Y., Foster, W. H., Deasy, B. M., Chan, Y., Prisk, V. R., Tang, Y., Cummins, J. H., & Huard, J. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63188-4 · Cited by 462
CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury
Moore, B. B., Kolodsick, J. E., Thannickal, V. J., Cooke, K. R., Moore, T. A., Hogaboam, C. M., Wilke, C. A., & Toews, G. B. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62289-4 · Cited by 440
Mechanisms of liver fibrosis and its role in liver cancer
Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219898141 · Cited by 449
Cardiac fibroblasts: friend or foe?
Baudino, T. A., Carver, W., Giles, W., & Borg, T. K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00023.2006 · Cited by 427
The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
Bellini, A., & Mattoli, S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700654 · Cited by 437
Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis
Chou, C.-H., Jain, V., Gibson, J., Attarian, D. E., Haraden, C. A., Yohn, C. B., Laberge, R.-M., Gregory, S., & Kraus, V. B. (2020) · Scientific Reports · doi:10.1038/s41598-020-67730-y · Cited by 398
Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair
Lech, M., & Anders, H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.001 · Cited by 441
Mesenchymal Cells of the Intestinal Lamina Propria
Powell, D. W., Pinchuk, I. V., Saada, J. I., Chen, X., & Mifflin, R. C. (2011) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100646 · Cited by 412
Cytokine mediated tissue fibrosis
Borthwick, L. A., Wynn, T. A., & Fisher, A. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.014 · Cited by 375
Rats and mice exhibit distinct inflammatory reactions after spinal cord injury
Sroga, J. M., Jones, T. B., Kigerl, K. A., McGaughy, V. M., & Popovich, P. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10736 · Cited by 369
Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis
Desmoulière, A., Darby, I. A., & Gabbiani, G. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000101911.53973.90 · Cited by 364
Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
Andersson‐Sjöland, A., de Alba, C. G., Nihlberg, K., Becerril, C., Ramı́rez, R., Pardo, A., Westergren‐Thorsson, G., & Selman, M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.012 · Cited by 360
Potential cellular and molecular causes of hypertrophic scar formation
van der Veer, W. M., Bloemen, M. C. T., Ulrich, M. M. W., Molema, G., van Zuijlen, P. P. M., Middelkoop, E., & Niessen, F. B. (2008) · Burns · doi:10.1016/j.burns.2008.06.020 · Cited by 362
Molecular pathology of wound healing
Kondo, T., & Ishida, Y. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.07.004 · Cited by 351
Fibroblasts and myofibroblasts in renal fibrosis
Meran, S., & Steadman, R. (2011) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2011.00764.x · Cited by 358
Origin of myofibroblasts and cellular events triggering fibrosis
Mack, M., & Yanagita, M. (2014) · Kidney International · doi:10.1038/ki.2014.287 · Cited by 346
Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury
Yamada, M., Kubo, H., Kobayashi, S., Ishizawa, K., Numasaki, M., Ueda, S., SUZUKI, T. A., & Sasaki, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1266 · Cited by 341
The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma
Baglieri, J., Brenner, D. A., & Kisseleva, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071723 · Cited by 347
Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice
Haudek, S. B., Xia, Y., Huebener, P., Lee, J. M., Carlson, S., Crawford, J. R., Pilling, D., Gomer, R. H., Trial, J., Frangogiannis, N. G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608799103 · Cited by 339
The reactive stroma microenvironment and prostate cancer progression
Barron, D. A., & Rowley, D. R. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0085 · Cited by 344
Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities
Varga, J., Trojanowska, M., & Kuwana, M. (2017) · Journal of Scleroderma and Related Disorders · doi:10.5301/jsrd.5000249 · Cited by 327
Cellular mechanisms of skin repair in humans and other mammals
Rittié, L. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0330-1 · Cited by 336
The Pathogenesis of Systemic Sclerosis
Katsumoto, T. R., Whitfield, M. L., & Connolly, M. K. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130312 · Cited by 324
The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis
Moore, B. B., Murray, L. A., Das, A., Wilke, C. A., Herrygers, A. B., & Toews, G. B. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0239oc · Cited by 309
Inhibition of Fibrocyte Differentiation by Serum Amyloid P 1
Pilling, D., Buckley, C., Salmon, M., & Gomer, R. (2003) · Journal of Immunology · doi:10.4049/jimmunol.171.10.5537 · Cited by 331
A stromal address code defined by fibroblasts
Parsonage, G., Filer, A. D., Haworth, O., Nash, G. B., Rainger, G. E., Salmon, M., & Buckley, C. D. (2005) · Trends in Immunology · doi:10.1016/j.it.2004.11.014 · Cited by 297
Biology of Fibroblasts and Myofibroblasts
Phan, S. H. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-146dr · Cited by 299
Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma
Curry, J., Sprandio, J. D., Cognetti, D. M., Luginbuhl, A., Bar‐Ad, V., Pribitkin, E. A., & Tuluc, M. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.03.003 · Cited by 295
Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration
Wu, Y., Zhao, R. C., & Tredget, E. E. (2010) · Stem Cells · doi:10.1002/stem.420 · Cited by 288
Concise Review: Multipotent Mesenchymal Stromal Cells in Blood
He, Q., Wan, C., & Li, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0335 · Cited by 290
Role of growth factors and the wound healing response in age-related macular degeneration
Schlingemann, R. O. (2003) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-003-0828-0 · Cited by 284
New Mechanisms of Pulmonary Fibrosis
Strieter, R. M., & Mehrad, B. (2009) · CHEST Journal · doi:10.1378/chest.09-0510 · Cited by 287
Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction
Ishii, G., Sangai, T., Oda, T., Aoyagi, Y., Hasebe, T., Kanomata, N., Endoh, Y., Okumura, C., Okuhara, Y., Magae, J., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01544-4 · Cited by 281
Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis
Sakai, N., Wada, T., Yokoyama, H., Lipp, M., Ueha, S., Matsushima, K., & Kaneko, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511200103 · Cited by 278
Mesenchymal stem cell therapy for attenuation of scar formation during wound healing
Jackson, W. M., Nesti, L. J., & Tuan, R. S. (2012) · Stem Cell Research & Therapy · doi:10.1186/scrt111 · Cited by 282
The role of CXC chemokines in pulmonary fibrosis
Strieter, R. M., Gomperts, B. N., & Keane, M. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30562 · Cited by 273
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation
Shao, D. D., Suresh, R., Vakil, V., Gomer, R. H., & Pilling, D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107782 · Cited by 277
Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury
Kigerl, K. A., McGaughy, V. M., & Popovich, P. G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20827 · Cited by 271
Liver fibrosis: cellular mechanisms of progression and resolution
Henderson, N. C., & Iredale, J. P. (2007) · Clinical Science · doi:10.1042/cs20060242 · Cited by 270
Concise Review: Clinical Translation of Wound Healing Therapies Based on Mesenchymal Stem Cells
Jackson, W. M., Nesti, L. J., & Tuan, R. S. (2011) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0024 · Cited by 276
Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo
Hartlapp, I., Abe, R., Saeed, R. W., Peng, T., Voelter, W., Bucala, R., & Metz, C. N. (2001) · The FASEB Journal · doi:10.1096/fj.01-0049com · Cited by 266
Self-citation
Fibroblasts as architects of cancer pathogenesis
Marsh, T., Pietras, K., & McAllister, S. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.013 · Cited by 277
The role of circulating fibrocytes in fibrosis
Quan, T. E., Cowper, S. E., & Bucala, R. (2006) · Current Rheumatology Reports · doi:10.1007/s11926-006-0055-x · Cited by 264
Self-citation
Defining the Cardiac Fibroblast
Ivey, M. J., & Tallquist, M. D. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-1003 · Cited by 258
Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease
Mehrad, B., Burdick, M. D., Zisman, D. A., Keane, M. P., Belperio, J. A., & Strieter, R. M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.149 · Cited by 255
Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition
Guarino, M., Tosoni, A., & Nebuloni, M. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.02.020 · Cited by 265
The Inflammation–Fibrosis Link? A Jekyll and Hyde Role for Blood Cells during Wound Repair
Stramer, B. M., Mori, R., & Martin, P. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700811 · Cited by 251
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine
Eyden, B. P. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00213.x · Cited by 261
New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M 2 activation in a CCL2/CCR2 axis
Sun, L., Louie, M. C., Vannella, K. M., Wilke, C. A., LeVine, A. M., Moore, B. B., & Shanley, T. P. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00122.2010 · Cited by 260
SPARC and tumor growth: Where the seed meets the soil?
Framson, P. E., & Sage, E. H. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20091 · Cited by 250
Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon
Brittan, M., Hunt, T., Jeffery, R., Poulsom, R., Forbes, S. J., Hodivala‐Dilke, K., Goldman, J. M., Alison, M. R., & Wright, N. A. (2002) · Gut · doi:10.1136/gut.50.6.752 · Cited by 250
Fibroblasts in the Tumor Microenvironment: Shield or Spear?
Alkasalias, T., Moyano‐Galceran, L., Arsenian‐Henriksson, M., & Lehti, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051532 · Cited by 251
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
Davie, N. J., Crossno, J. T., Frid, M. G., Hofmeister, S. E., Reeves, J. Τ., Hyde, D. M., Carpenter, T. C., Brunetti, J. A., McNiece, I., & Stenmark, K. R. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00108.2003 · Cited by 249
Multiple Organ Engraftment by Bone‐Marrow‐Derived Myofibroblasts and Fibroblasts in Bone‐Marrow‐Transplanted Mice
Direkze, N. C., Forbes, S. J., Brittan, M., Hunt, T., Jeffery, R. E., Preston, S. L., Poulsom, R., Hodivala‐Dilke, K., Alison, M. R., & Wright, N. A. (2003) · Stem Cells · doi:10.1634/stemcells.21-5-514 · Cited by 246
Differentiation of Muscle-Derived Cells into Myofibroblasts in Injured Skeletal Muscle
Li, Y., & Huard, J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64250-2 · Cited by 243
Origins of Cardiac Fibroblasts
Zeisberg, E. M., & Kalluri, R. (2010) · Circulation Research · doi:10.1161/circresaha.110.231910 · Cited by 247
Hepatic fibrosis and cirrhosis: The (myo)fibroblastic cell subpopulations involved
Guyot, C., Lepreux, S., Combe, C., Doudnikoff, É., Bioulac‐Sage, P., Balabaud, C. P., & Desmoulière, A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.08.021 · Cited by 247
Peripheral Blood Fibrocytes from Burn Patients: Identification and Quantification of Fibrocytes in Adherent Cells Cultured from Peripheral Blood Mononuclear Cells
Yang, L., Scott, P. G., Giuffre, J. L., Shankowsky, H. A., Ghahary, A., & Tredget, E. E. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000027841.50269.61 · Cited by 242

Authors: Abe, R., Donnelly, S. C., Peng, T., Bucala, R., & Metz, C. N.
Affiliations: Laboratory of Vascular Biology, The Picower Institute for Medical Research , Manhasset, NY 11030
Laboratory of Medical Biochemistry, The Picower Institute for Medical Research , Manhasset, NY 11030
Corresponding author: Abe, Riichiro
Peng, Tina
ORCID: Abe, Riichiro
Donnelly, Seamas C
Bucala, Richard
Metz, Christine N
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2001-06
Volume: 166
Issue: 12
Pages: 7556-7562
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.166.12.7556
OpenAlex: W4248565951
Cited by: 967
References: 40
Citations by year: 2026: 13 · 2025: 15 · 2024: 22 · 2023: 25 · 2022: 28 · 2021: 23 · 2020: 37 · 2019: 30 · 2018: 34 · 2017: 31 · 2016: 43 · 2015: 47 · 2014: 58 · 2013: 59 · 2012: 68
FWCI: 27.32
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: fibrocytes, fibrocyte differentiation, wound healing, TGF-β1, CCR7, tissue damage, myofibroblasts, alpha-smooth muscle actin, collagen gel contraction
MeSH terms: Animals, Blood Cells, Cell Differentiation, Cell Movement, Cells, Cultured, Collagen, Female, Fibroblasts, Fibrosis, Gels, Humans, Injections, Intravenous, Mice, Inbred BALB C, Stem Cells, Wound Healing, Transforming Growth Factor beta, Lipopolysaccharide Receptors, Receptors, Chemokine, Stem Cell Transplantation, Mice, Transforming Growth Factor beta1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks