CoChat
Sign Up
Cited by 722T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisRheumatoid Arthritis Research and Therapies

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

Open access
Chtanova, Tatyana, Tangye, Stuart G, Newton, Rebecca, Frank, Nita, Hodge, Martin R, Rolph, Michael S, Mackay, Charles R·2004·The Journal of Immunology
DOI 10.4049/jimmunol.173.1.68
Open this paper in CoChat — free accountOpen PDF

Abstract

Effector T cell responses have long been viewed in the context of the Th1/Th2 paradigm. Recently, a third major subset of nonpolarized effector T cells that provides help to B cells has been identified. These T cells, termed T follicular helper (TFH) cells, home to the B cell areas of secondary lymphoid tissue, through interactions mediated via the chemokine receptor CXCR5 and its ligand CXCL13. Affymetrix microarrays were used to identify transcription factors, cytokines, and cell surface molecules that underlie the differentiation pathways and functional properties of the TFH subset. The transcriptional profile of human CXCR5+ TFH cells was compared with that of Th1 and Th2 cells, which enabled the identification of numerous genes expressed preferentially by TFH cells, over the other effector subsets. Certain TFH genes were also expressed by B cells and thus appear to be particularly relevant for humoral immunity. Abs were used to confirm the expression of several factors. In particular, CD84 and CD200, the cytokine IL-21, and the transcription factor BCL6 were all strongly associated with TFH cells. Gene microarrays reveal a highly distinctive transcriptional profile for a third subset of effector T cells that differs markedly from Th1 and Th2 cells.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4049/jimmunol.173.1.68

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 64 references

Research works printed but not linked: 64

  1. 1994, Annu. Rev. Immunol., 117
  2. 1999, Science, 2098
  3. 1996, Nature, 787
  4. 1988, Immunol. Rev., 5
  5. 1998, Immunity, 275
  6. 1995, Immunol. Rev., 45
  7. 1996, Nature, 630
  8. 2000, J. Exp. Med., 1545
  9. 2000, J. Exp. Med., 1553
  10. 2001, J. Exp. Med., 1373
  11. 1996, Cell, 1037
  12. 2000, Nature, 309
  13. 2003, Immunol. Lett., 105
  14. 2002, Nat. Rev. Immunol., 933
  15. 2003, J. Immunol., 1657
  16. 1996, J. Exp. Med., 2437
  17. 1996, J. Exp. Med., 473
  18. 2001, Nucleic Acids Res., E29
  19. 2000, Nat. Genet., 96
  20. 2001, J. Immunol., 3057
  21. 2001, Adv. Immunol., 233
  22. 1995, J. Immunol., 2533
  23. 1997, Nat. Genet., 161
  24. 2000, Immunity, 199
  25. 2000, J. Immunol., 786
  26. 1995, Eur. J. Immunol., 2825
  27. 1995, Proc. Natl. Acad. Sci. USA, 11249
  28. 1997, Blood, 2398
  29. 2001, Blood, 3513
  30. 2002, Eur. J. Immunol., 1640
  31. 2001, Blood, 3867
  32. 2001, Clin. Immunol., 15
  33. 2003, J. Immunol., 2485
  34. 2003, Nature, 282
  35. 1998, Nature, 462
  36. 1999, J. Immunol., 6981
  37. 2001, J. Exp. Med., 235
  38. 2002, Immunogenetics, 394
  39. 1999, J. Immunol., 5860
  40. 2001, J. Immunol., 5517
  41. 1997, J. Exp. Med., 993
  42. 1995, Nature, 260
  43. 2000, J. Immunol., 2932
  44. 2000, Immunity, 233
  45. 2000, Science, 1768
  46. 1996, Proc. Natl. Acad. Sci. USA, 6947
  47. 1995, Blood, 45
  48. 2000, Semin. Immunol., 149
  49. 2003, Nat. Immunol., 19
  50. 2001, J. Immunol., 3668
  51. 2000, Nature, 57
  52. 2001, J. Immunol., 1
  53. 1993, Cell, 147
  54. 2001, Nat. Rev. Immunol., 200
  55. 2002, J. Leukocyte Biol., 856
  56. 2003, J. Immunol., 5464
  57. 2002, Immunity, 559
  58. 2002, J. Exp. Med., 969
  59. Cell, 265
  60. 1996, Blood, 5257
  61. 1995, Blood, 28
  62. 2000, J. Exp. Med., 1841
  63. 2003, J. Immunol., 2435
  64. 2003, Eur. J. Immunol., 1105

Cited by

Sorted by citations

See all 722

Related

Metadata

Authors
Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., & Mackay, C. R.
Affiliations
  • The University of Sydney (AU)
  • Centenary Institute (AU)
  • Garvan Institute of Medical Research (AU)
  • Takeda Oncology (United States) (US)
Corresponding author
  • Chtanova, Tatyana
  • Newton, Rebecca
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2004-07-01
Volume
173
Issue
1
Pages
68-78
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.173.1.68
OpenAlex
W2113687173
Cited by
722
References
64
Citations by year
2026: 9 · 2025: 17 · 2024: 7 · 2023: 21 · 2022: 22 · 2021: 23 · 2020: 30 · 2019: 31 · 2018: 25 · 2017: 33 · 2016: 35 · 2015: 37 · 2014: 43 · 2013: 43 · 2012: 64
FWCI
8.87
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
T follicular helper cells, gene expression profiling, CXCR5, CXCL13, Th1/Th2 paradigm, B cell help, humoral immunity, CD84, CD200, IL-21, BCL6, T cell differentiation, secondary lymphoid organs
MeSH terms
Signaling Lymphocytic Activation Molecule Family, Interleukin-21, B-Lymphocytes, DNA-Binding Proteins, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Proto-Oncogene Proteins, Transcription Factors, Antigens, CD, Receptors, Cytokine, CD57 Antigens, Receptors, Chemokine, Gene Expression Profiling, Proto-Oncogene Proteins c-bcl-6, Receptors, CXCR5

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review