The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease
Open accessAbstract
More than 60% of STAT6−/− mice immunologically reject spontaneous metastatic mammary carcinoma and survive indefinitely if their primary tumors are removed, whereas 95% of STAT6-competent BALB/c mice succumb to metastatic disease. BALB/c and STAT6-deficient mice with primary tumors have elevated levels of Gr1+CD11b+ myeloid suppressor cells (MSCs), which inhibit T cell activation. After removal of primary tumor, MSC levels revert to baseline in STAT6-deficient mice, but remain elevated in BALB/c mice. The decrease is IFN-γ dependent, as is the reduction in metastatic disease. Neither BALB/c nor STAT6-deficient MSCs produce inducible NO synthase; however, both produce arginase and reactive oxygen species. STAT6-deficient mice produce M1 macrophages, which contain high levels of NO and are tumoricidal, whereas BALB/c mice produce M2 macrophages, which make arginase and are not tumoricidal. Immunity in STAT6-deficient mice requires the activation of NO-producing M1 macrophages that are tumoricidal, the reduction in MSC levels to baseline after surgical removal of primary tumor, and the activation of tumor-specific T cells. These mechanisms occur in STAT6−/− mice because STAT6 deficiency prevents signaling through the type 2 IL-4Rα, thereby blocking the production of arginase and promoting the synthesis of NO.
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Cites
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Metadata
- Authors
- Sinha, P., Clements, V. K., & Ostrand-Rosenberg, S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01
- Volume
- 174
- Issue
- 2
- Pages
- 636-645
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2116013738
- Cited by
- 466
- References
- 56
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sinha, P., Clements, V. K., & Ostrand-Rosenberg, S. (2005). Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease. The Journal of Immunology. https://doi.org/10.4049/jimmunol.174.2.636
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