The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Functional Properties and Lineage Relationship of CD8+ T Cell Subsets Identified by Expression of IL-7 Receptor α and CD62L
Open accessAbstract
Three major subsets of Ag-experienced CD8+ T cells have been identified according to their expression of CD62L and CD127. These markers are associated with central memory T cells (CD62L+CD127+), effector memory T cells (CD162L−CD127+), and effector T cells (CD62L−CD127−). In this study we characterized the development of these three populations during acute and chronic viral infections and after immunization with virus-like particles and determined their lineage relation and functional and protective properties. We found that the balance between the three subsets was critically regulated by the availability of Ag and time. After initial down-regulation of CD127, the responding CD8+ T cell population down-regulated CD62L and re-expressed CD127. Dependent on Ag availability, the cells then further differentiated into CD62L−CD127− effector cells or, in the absence of Ag, re-expressed CD62L to become central memory T cells. Although all three populations efficiently produced effector cytokines such as IFN-γ, CD62L−CD127− effector cells exhibited the highest ex vivo lytic potential. In contrast, CD62L+CD127+ central memory T cells most efficiently produced IL-2 and proliferated extensively in vitro and in vivo upon antigenic restimulation. Strikingly, only effector and effector memory, but not central memory, T cells were able to protect against peripheral infection with vaccinia virus, whereas central memory T cells were most potent at protecting against systemic infection with lymphocytic choriomeningitis virus, indicating that the antiviral protective capacities of specific CD8+ T cell subsets are closely related to the nature of the challenging pathogen.
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Cites
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“Effector and TEM T cell populations express low levels of CD62L and CCR7, whereas naive and central memory cells express high levels of CD62L and CCR7.”
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“Adoptively transferred CD127 CD8 T but not CD127 CD8 T cells survived in the absence of Ag by homeostatic proliferation and thus maintenance via CD127 (13, 22).”
BackgroundInfluential
Cited by
CD8 + T‐cell memory in tumor immunology and immunotherapy
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Four functionally distinct populations of human effector-memory CD8+ T lymphocytes
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Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses
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Metadata
- Authors
- Bachmann, M. F., Wolint, P., Schwarz, K., Jäger, P., & Oxenius, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-10-01
- Volume
- 175
- Issue
- 7
- Pages
- 4686-4696
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1512247569
- Cited by
- 276
- References
- 72
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bachmann, M. F., Wolint, P., Schwarz, K., Jäger, P., & Oxenius, A. (2005). Functional Properties and Lineage Relationship of CD8+ T Cell Subsets Identified by Expression of IL-7 Receptor α and CD62L. The Journal of Immunology. https://doi.org/10.4049/jimmunol.175.7.4686
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