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Lung Macrophages Serve as Obligatory Intermediate between Blood Monocytes and Alveolar Macrophages
Open accessAbstract
Alveolar macrophages are a unique type of mononuclear phagocytes that populate the external surface of the lung cavity. Early studies have suggested that alveolar macrophages originate from tissue-resident, local precursors, whereas others reported their derivation from blood-borne cells. However, the role of circulating monocytes as precursors of alveolar macrophages was never directly tested. In this study, we show through the combined use of conditional cell ablation and adoptive cell transfer that alveolar macrophages originate in vivo from blood monocytes. Interestingly, this process requires an obligate intermediate stage, the differentiation of blood monocytes into parenchymal lung macrophages, which subsequently migrate into the alveolar space. We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate.
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“These results support the findings that the origin of the AM pool is mainly through differentiation of intermediate lung macrophages rather than self-proliferation (24).”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [24]
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2 retracted
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Metadata
- Authors
- Landsman, L., & Jung, S.
- Affiliations
- Weizmann Institute of Science (IL)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09
- Volume
- 179
- Issue
- 6
- Pages
- 3488-3494
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2170851221
- Cited by
- 258
- References
- 51
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 23 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 27 · 2015: 11 · 2014: 23 · 2013: 20 · 2012: 18
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- alveolar macrophages, lung macrophages, blood monocytes, monocyte-to-macrophage differentiation, monocyte-derived macrophages, macrophage proliferation, adoptive cell transfer
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Diphtheria Toxin, Growth Inhibitors, Lung, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Monocytes, Stem Cells, Bone Marrow Transplantation, Macrophages, Alveolar, Adoptive Transfer, Cell Proliferation, Mice
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