Herpesvirus chemokine-binding glycoprotein G (gG) efficiently inhibits neutrophil chemotaxis in vitro and in vivo.
Abstract
Glycoprotein G (gG) of alphaherpesviruses has been described to function as a viral chemokine-binding protein (vCKBP). More recently, mutant viruses devoid of gG have been shown to result in increased virulence, but it remained unclear whether the potential of gG to serve as a vCKBP is responsible for this observation. In this study, we used equine herpesvirus type 1 (EHV-1) as a model to study the pathophysiological importance of vCKBP activity. First, in vitro chemotaxis assays studying migration of immune cells, an important function of chemokines, were established. In such assays, supernatants of EHV-1-infected cells significantly inhibited IL-8-induced chemotaxis of equine neutrophils. Identification of gG as the responsible vCKBP was achieved by repeating similar experiments with supernatants from cells infected with a gG-negative mutant, which were unable to alter IL-8-induced equine neutrophil migration. Furthermore, rEHV-1 gG was able to significantly reduce neutrophil migration, establishing gG as a bona fide vCKBP. Second, and importantly, in vivo analyses in a murine model of EHV-1 infection showed that neutrophil migration in the target organ lung was significantly reduced in the presence of gG. In summary, we demonstrate for the first time that EHV-1 gG not only binds to chemokines but is also capable of inhibiting their chemotactic function both in vitro and in vivo, thereby contributing to viral pathogenesis and virulence.
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EHV-1 gG inhibits migration of equine neutrophils in response to equine recombinant IL-8.
“EHV-1 gG is also able to inhibit migration of equine neutrophils in response to equine recombinant IL-8 (Van de Walle et al., 2007).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Van de Walle et al., 2007
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- Authors
- Van de Walle, G. R., May, M. L., Sukhumavasi, W., von Einem, J., & Osterrieder, N.
- Affiliations
- Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University , Ithaca, NY 14853
- Cornell University (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09
- Volume
- 179
- Issue
- 6
- Pages
- 4161-4169
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2106473364
- Cited by
- 55
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- equine herpesvirus 1, neutrophil chemotaxis, interleukin-8, viral virulence, alphaherpesvirus, viral pathogenesis
- MeSH terms
- Animals, Binding, Competitive, Cell Line, Cell Migration Inhibition, Cell-Free System, Chemotaxis, Leukocyte, Herpesvirus 1, Equid, Female, Herpesviridae Infections, Horses, Neutrophils, Pneumonia, Viral, Protein Binding, Rabbits, Viral Envelope Proteins, Virulence, Interleukin-8, Chemokines, Chemokine CCL2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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