The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination
Abstract
The innate immune system recognizes influenza A virus via TLR 7 or retinoic acid-inducible gene I in a cell-type specific manner in vitro, however, physiological function(s) of the MyD88- or interferon-β promoter stimulator 1 (IPS-1)-dependent signaling pathways in antiviral responses in vivo remain unclear. In this study, we show that although either MyD88- or IPS-1-signaling pathway was sufficient to control initial antiviral responses to intranasal influenza A virus infection, mice lacking both pathways failed to show antiviral responses, resulting in increased viral load in the lung. By contrast, induction of B cells or CD4 T cells specific to the dominant hemagglutinin or nuclear protein Ags respectively, was strictly dependent on MyD88 signaling, but not IPS-1 signaling, whereas induction of nuclear protein Ag-specific CD8 T cells was not impaired in the absence of either MyD88 or IPS-1. Moreover, vaccination of TLR7- and MyD88-deficient mice with inactivated virus failed to confer protection against a lethal live virus challenge. These results strongly suggest that either the MyD88 or IPS-1 signaling pathway is sufficient for initial antiviral responses, whereas the protective adaptive immune responses to influenza A virus are governed by the TLR7-MyD88 pathway.
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Cites
A Toll-like receptor recognizes bacterial DNA
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Self-citationDifferential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Self-citationCardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
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Cited by
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Self-citationToll-like receptors and their crosstalk with other innate receptors in infection and immunity
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Self-citationImmune Signaling by RIG-I-like Receptors
Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875
Trex1 prevents cell-intrinsic initiation of autoimmunity
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Metadata
- Authors
- Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T., & Akira, S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-01
- Volume
- 179
- Issue
- 7
- Pages
- 4711-4720
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2137781960
- Cited by
- 309
- References
- 9
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination. https://app.cochat.ai/papers/10.4049/jimmunol.179.7.4711
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- Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T., & Akira, S. (2007). Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination. The Journal of Immunology. https://doi.org/10.4049/jimmunol.179.7.4711
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